Results 51 to 60 of about 86,202 (271)

Synergistic Chondroprotective Effect of α-Tocopherol, Ascorbic Acid, and Selenium as well as Glucosamine and Chondroitin on Oxidant Induced Cell Death and Inhibition of Matrix Metalloproteinase-3—Studies in Cultured Chondrocytes

Molecules, 2009
Overproduction of reactive oxygen species and impaired antioxidant defence accompanied by chronic inflammatory processes may impair joint health. Pro-inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNF-α) stimulate ...
Anne-Christi Graeser, Katri Giller, Heike Wiegand, Luca Barella, Christine Boesch Saadatmandi, Gerald Rimbach   +5 more
doaj   +1 more source

The preventive effects of two nutraceuticals on experimentally induced acute synovitis [PDF]

, 2017
Background: Nutraceuticals are often used in the management of equine osteoarthritis, but scientific evidence of their efficacy is lacking. Objectives: To study the preventive effects of two new nutraceuticals after the experimental induction of ...
American Association of Equine Practitioners, Bassage, Benito, Billinghurst, Brien, Bruyère, Burham, Byron, Cayzer, Chan, Clark, Coenen, Debbi, Dechant, Ebisuzaki, Faul, Grauw, Grauw, Grauw, Gupta, Hanson, Laverty, Marañón, Meulyzer, Neil, Neundorf, Oesser, Oosterlinck, Orth, Pearson, Pearson, Pearson, Smith, Trumble, Usha, Vandeweerd, Welch   +36 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Biphasic role of chondroitin sulfate in cardiac differentiation of embryonic stem cells through inhibition of Wnt/β-catenin signaling. [PDF]

PLoS ONE, 2014
The glycosaminoglycan chondroitin sulfate is a critical component of proteoglycans on the cell surface and in the extracellular matrix. As such, chondroitin sulfate side chains and the sulfation balance of chondroitin play important roles in the control ...
Robert D Prinz, Catherine M Willis, Toin H van Kuppevelt, Michael Klüppel   +3 more
doaj   +1 more source

Metabolomics in psoriatic disease: pilot study reveals metabolite differences in psoriasis and psoriatic arthritis. [PDF]

, 2014
ImportanceWhile "omics" studies have advanced our understanding of inflammatory skin diseases, metabolomics is mostly an unexplored field in dermatology.ObjectiveWe sought to elucidate the pathogenesis of psoriatic diseases by determining the differences
Armstrong, April W, Azizi, Baktazh, Dhillon, Jaskaran, Fiehn, Oliver, Grapov, Dmitry, Johnson, Mary Ann, Wu, Julie   +6 more
core   +2 more sources

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Increased Cerebral Serum Amyloid A2 and Parameters of Oxidation in Arylsulfatase B (N-Acetylgalactosamine-4-Sulfatase)-Null Mice

Journal of Alzheimer's Disease Reports, 2023
Background: Chondroitin sulfate and chondroitin sulfate proteoglycans have been associated with Alzheimer’s disease (AD), and the impact of modified chondroitin sulfates is being investigated in several animal and cell-based models of AD.
Sumit Bhattacharyya, Joanne K. Tobacman
doaj   +1 more source

Evaluation of mesalazine polymeric conjugate in the treatment of actinic proctitis in rats

Acta Cirúrgica Brasileira, 2021
Purpose: The present study aimed at testing a new formulation of mesalazine linked to chondroitin sulfate and its components alone in the treatment of actinic proctitis in rats.
Vinícius Rodrigues Taranto Nunes, Paula Vieira Teixeira Vidigal, Márcio Tadeu Pereira, Luís Carlos Duarte Ladeira, Marcelo Vidigal Caliari, Fabrício Marcus Silva Oliveira, Aina Liz Alves Cesar, André Augusto Gomes Faraco, Rafael Calvão Barbuto, Ivana Duval-Araujo   +9 more
doaj   +1 more source

Avian neural crest cell migration is diversely regulated by the two major hyaluronan-binding proteoglycans PG-M/versican and aggrecan [PDF]

, 2000
It has been proposed that hyaluronan-binding proteoglycans play an important role as guiding cues during neural crest (NC) cell migration, but their precise function has not been elucidated.
Bellina, Isabella, Bronner-Fraser, Marianne, Colombatti, Alfonso, Doliana, Roberto, Iacopetti, Paola, Kimata, Koji, Löfberg, Jan, Mörgelin, Matthias, Perissinotto, Daniela, Perris, Roberto, Pettway, Zoé, Shinomura, Tamayuki   +11 more
core  

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source