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Biosynthesis and function of chondroitin sulfate
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular and extracellular components that form regulatory milieu involving numerous biological and pathophysiological phenomena. Diverse functions of CSPGs can be mainly attributed to structural variability of their polysaccharide moieties, chondroitin sulfate glycosaminoglycans (CS-GAG ...
Hiroshi Kitagawa, Tadahisa Mikami
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Calcium binding by chondroitin sulfate
Calcified Tissue Research, 1968The binding of calcium by chondroitin sulfate C was studied by employing biological and physicochemical methods for the quantitative determination of ionic calcium. Mean values for logKj, the logarithm of the uncorrected formation constant for a calcium-chondroitin sulfate complex, were 1.64 with the frog heart technique, 1.55 with the murexide method,
Basil S. Strates +3 more
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Conjugation of chondroitin sulfates with amines
Russian Journal of Bioorganic Chemistry, 2008Conjugation of chondroitin sulfates with pharmacologically important amines in a water medium in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide was studied. Conjugates with amide and isoureidocarbonyl groups were synthesized.
E. S. Lukina +3 more
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Synthesis of Chondroitin Sulfate Oligosaccharides and Chondroitin Sulfate Glycopeptides
2019Chondroitin sulfate (CS) and chondroitin sulfate proteoglycan (CSPG) belong to the glycosaminoglycan (GAG) family, a class of poly-anionic glyco-conjugates widely expressed by animal cells. They play important roles in many biological events. Here, we summarize the main considerations in the design of chemical and enzymatic methodologies to access ...
Xuefei Huang +2 more
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Chondroitin Sulfate Proteoglycans in the Brain
2006Publisher Summary Chondroitin sulfate proteoglycans (CSPGs) play important roles in the morphogenesis and maintenance of various tissues, including the central nervous system (CNS), through the interactions of their core proteins and/or chondroitin sulfate (CS) chains with cell adhesion molecules, extracellular matrix (ECM) molecules, and growth ...
Sachiko Aono, Atsuhiko Oohira
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Biosynthesis of Chondroitin/Dermatan Sulfate
IUBMB Life, 2002AbstractChondroitin sulfate and dermatan sulfate are synthesized as galactosaminoglycan polymers containing N ‐acetylgalactosmine alternating with glucuronic acid. The sugar residues are sulfated to varying degrees and positions depending upon the tissue sources and varying conditions of formation.
Jeremiah E. Silbert, Geetha Sugumaran
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Chondroitin Sulfate in Osteoarthritis Therapy
Orthopedics, 2009Despite the news of aid from chondroitin sulfate, recent research has questioned its efficacy in treating osteoarthritis.
Jonathan D Morris, Kelly M. Smith
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Antioxidant Activity of Chondroitin Sulfate
2006Publisher Summary Molecules in biological systems often perform more than one function. Many structures have the ability to scavenge free radicals, acting in living organisms as antioxidants, although their main biological function is different. During oxidative stress, the increase in the concentration of these molecules seems to be a biological ...
Adriana Ferlazzo +4 more
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Microbial production and metabolic engineering of chondroitin and chondroitin sulfate
Emerging Topics in Life Sciences, 2018Several commercial uses and potential novel applications have recently been described for chondroitin sulfate (CS). However, the currently applied animal extractive procedure has a high environmental impact, which may become more profound especially in relation to the forecasted expansion of the CS market for applications as a food supplement ...
Cimini D., Restaino O. F., Schiraldi C.
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In Vitro Effects of Chondroitin Sulfate
2006Publisher Summary A number of in vitro studies have been performed to determine the mode of action of chondroitin sulfate (CS). It has been demonstrated that CS possesses both anabolic effects on cartilage metabolism and anticatabolic properties. In various models of cartilage culture or of isolated chondrocytes, CS has demonstrated the capacity to ...
A. Fioravanti, G. Collodel
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