Results 31 to 40 of about 15,622 (209)
Opticin Binds to Heparan and Chondroitin Sulfate Proteoglycans
Investigative Opthalmology & Visual Science, 2005 The extracellular matrix glycoprotein opticin is a small leucine-rich repeat proteoglycan/protein family member that was discovered associated with vitreous humor collagen fibrils. Opticin is present throughout the vitreous, but is particularly concentrated at the internal limiting lamina, where it colocalizes with type XVIII collagen.
Hindson, V. John +3 more
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Syndecans in Inflammation at a Glance
Frontiers in Immunology, 2020 Syndecans are transmembrane proteoglycans with heparan and chondroitin sulfate chains attached to their extracellular domain. Like many proteoglycans, they interact with a large number of ligands, such as growth factors, adhesion receptors, soluble small
Sandeep Gopal
doaj +1 more source
ASN Neuro, 2010 The heparan sulfate proteoglycan glypican-1, the chondroitin sulfate proteoglycan phosphacan/RPTP (receptor protein-tyrosine phosphatase)-ζ/β and the extracellular matrix protein tenascin-C were all found to be expressed by neural stem cells and by ...
Mary Abaskharoun +3 more
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Oncofetal Chondroitin Sulfate: A Putative Therapeutic Target in Adult and Pediatric Solid Tumors
Cells, 2020 Solid tumors remain a major challenge for targeted therapeutic intervention strategies such as antibody-drug conjugates and immunotherapy. At a minimum, clear and actionable solid tumor targets have to comply with the key biological requirement of being ...
Nastaran Khazamipour +6 more
doaj +1 more source
Biosynthesis of the Chondroitin Sulfate Proteoglycan
Journal of Biological Chemistry, 1972 Abstract Xylosyltransferase from embryonic chick epiphyseal cartilage catalyzes the transfer of xylose from UDP-xylose to particulate endogenous acceptors or to an exogenous protein acceptor obtained by Smith degradation of bovine chondroitin sulfate-protein complex.
Allen C. Stoolmiller +3 more
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Expanding the Chondroitin Sulfate Glycoproteome — But How Far?
Frontiers in Cell and Developmental Biology, 2021 Chondroitin sulfate proteoglycans (CSPGs) are found at cell surfaces and in connective tissues, where they interact with a multitude of proteins involved in various pathophysiological processes.
Fredrik Noborn +5 more
doaj +1 more source
Agrin and perlecan mediate tumorigenic processes in oral squamous cell carcinoma. [PDF]
PLoS ONE, 2014 Oral squamous cell carcinoma is the most common type of cancer in the oral cavity, representing more than 90% of all oral cancers. The characterization of altered molecules in oral cancer is essential to understand molecular mechanisms underlying tumor ...
Rebeca Kawahara +12 more
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Effects of receptor clustering on ligand dissociation: Theory and simulations [PDF]
Biophys. J. 89 (2005) 3685, 2004 Receptor-ligand binding is a critical first step in signal transduction and the duration of the interaction can impact signal generation. In mammalian cells, clustering of receptors may be facilitated by heterogeneous zones of lipids, known as lipid rafts.
arxiv +1 more source
N-acetylgalactosamine positive perineuronal nets in the saccade-related-part of the cerebellar fastigial nucleus do not maintain saccade gain. [PDF]
PLoS ONE, 2014 Perineuronal nets (PNNs) accumulate around neurons near the end of developmental critical periods. PNNs are structures of the extracellular matrix which surround synaptic contacts and contain chondroitin sulfate proteoglycans.
Adrienne Mueller +3 more
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Chondroitin sulfate proteoglycans in neural development and plasticity
Frontiers in Bioscience, 2010 PTPzeta and lectican family members are major chondroitin sulfate proteoglycans (CS-PGs) in the brain, which bind with many proteins via core protein and CS portions. Recent studies revealed that the oversulfated structures in CS constitute high affinity binding sites for various growth factors and axon guidance molecules, and play important roles in ...
Maki Ishii +2 more
openaire +3 more sources