Chondroitin Sulfate Proteoglycans Are Associated with the Lesions of Alzheimer's Disease
Chondroitin sulfate proteoglycans (CSPG) are extracellular matrix proteins inhibitory to neurite outgrowth in vitro and correlated with decreased neurite outgrowth after CNS injury. Previously, heparan sulfate proteoglycan and dermatan sulfate proteoglycan have been shown to be associated with senile plaques (SPs) and neurofibrillary tangles (NFTs) but
Dewitt, David A.+3 more
openaire +5 more sources
Geochemistry constrains global hydrology on Early Mars [PDF]
Ancient hydrology is recorded by sedimentary rocks on Mars. The most voluminous sedimentary rocks that formed during Mars' Hesperian period are sulfate-rich rocks, explored by the $Opportunity$ rover from 2004-2012 and soon to be investigated by the $Curiosity$ rover at Gale crater.
arxiv +1 more source
Damage in porous media due to salt crystallization [PDF]
We investigate the origins of salt damage in sandstones for the two most common salts: sodium chloride and sulfate. The results show that the observed difference in damage between the two salts is directly related to the kinetics of crystallization and the interfacial properties of the salt solutions and crystals with respect to the stone. We show that,
arxiv +1 more source
Chondroitin Sulfate and Heparan Sulfate Proteoglycans of PC12 Pheochromocytoma Cells
We have isolated and characterized the cell-associated and secreted proteoglycans synthesized by a clonal line of rat adrenal medullary PC12 pheochromocytoma cells, which have been extensively employed for the study of a wide variety of neurobiological processes. Chondroitin sulfate accounts for 70-80% of the [35S] sulfate-labeled proteoglycans present
Richard U. Margolis+3 more
openaire +3 more sources
After nerve-root avulsion injury of the brachial plexus, oxidative damage, inflammatory reaction, and glial scar formation can affect nerve regeneration and functional recovery.
Wen-Lai Guo+7 more
doaj +1 more source
The Affinity of the Sulfate- and Ether-Containing Surface-Active Ionic Liquids to Carbon Dioxide, Hydrogen Fluoride, Hydrogen Sulfide, and Water [PDF]
The development of novel task-specific ionic liquids (ILs) represents an essential challenge in modern organic and physical chemistries. Recently we reported surface-active ILs contained the two well-known organic cations (1-butyl-3-methylimidazolium and tetrabutylammonium) and the two surface-active anions (lauryl sulfate, lauryl ether sulfate).
arxiv
Demyelination failure in multiple sclerosis (MS) may contribute to the disease progression. This study shows that chondroitin sulfate proteoglycans (CSPGs) can inhibit remyelination in an animal model of MS via CSPG binding with the receptor PTPσ on ...
Fucheng Luo+6 more
doaj +1 more source
Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue
Osteoarthritis is one of the most common diseases of the connective tissue of the elderly. It was found that most epidemiological studies used the Kellgren and Lawrence system for classification of osteoarthritis, which indicates one of the 5 degrees (0 ...
Stanislav Sukhikh+4 more
doaj +1 more source
Correlations between Chondroitin Sulfate Physicochemical Properties and its in-vitro Absorption and Anti-inflammatory Activity [PDF]
Here, we investigated the influence of physicochemical characteristics of chondroitin sulfate (CS) on its in vitro absorption and anti-inflammatory activity. We used eight different synthetic and natural CS samples with a range of molecular weights (7-35 kDa) and sulfation patterns.
arxiv
Instant determination of the potential biomarker heparan sulfate in human plasma by a mix-and-read fluorescence assay [PDF]
Heparan sulfate (HS) is a linear, polydisperse sulfated polysaccharide belonging to the glycosaminoglycan family. HS proteoglycans are ubiquitously found at the cell surface and extracellular matrix in animal species. HS is involved in the interaction with a wide variety of proteins and the regulation of many biological activities.
arxiv