Results 121 to 130 of about 49,505 (301)

Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity

Our brain is bathed in cerebrospinal fluid (CSF) that is produced by the choroid plexus. CSF serves as a dispersion route for hormones and nutrients, and a conduit for waste clearance.
Toft-Bertelsen, Trine L., Chiara Salio, Andersen, Jens Velde, Andreassen, Søren N., Patrizi, Annarita, MacAulay, Nanna, Dela, Flemming, Trapp, Marleen, Westi, Emil W., Blanca I. Aldana, Nanna MacAulay, Wardman, Jonathan H., Jens Velde Andersen, Emil W. Westi, Lolansen, Sara D., Eszter O. Révész, Flemming Dela, Jonathan H. Wardman, Salio, Chiara, Marco Sassoé-Pognetto, Trine L. Toft-Bertelsen, Anne-Kristine Meinild Lundby, Révész, Eszter O., Sassoé-Pognetto, Marco, Søren N. Andreassen, Aldana, Blanca I., Sara D. Lolansen, Lundby, Anne Kristine Meinild, Annarita Patrizi, Marleen Trapp   +29 more
core   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells

The FEBS Journal, EarlyView.
D‐amino acid oxidase (DAO) in choroid plexus epithelial cells (CPECs) shows vesicle‐like localization by histological and super‐resolution analyses. DAO colocalizes with peroxisomal, Golgi, endosomal, lysosomal, autophagosomal, and exosomal markers, indicating diverse subcellular distribution. This suggests DAO is transported within CPECs to metabolize
Koji Ono, Yuji Shishido, Toshiyuki Yamagishi, Kiyoshi Fukui   +3 more
wiley   +1 more source

Potential relationship between periodontal diseases and eye diseases

, 2017
International audiencePeriodontal diseases are inflammatory lesions initiated by oral bacteria and lead to the destruction of the supporting structures of the teeth (gingiva, periodontal ligament and alveolar bone) in susceptible patient.
Soueidan, A., Badran, Z., Struillou, X., Pockpa, Z., Weber, M., Coulibaly, N.T   +5 more
core   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

A 19‐year‐old woman with intermittent headache and dizziness and a large temporal lobe mass

Brain Pathology, EarlyView.
Sha‐Sha Hu, Wei Yan, Bo Wang
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq

, 2014
Proper spatial differentiation of retinal cell types is necessary for normal human vision. Many retinal diseases, such as Best disease and male germ cell associated kinase (MAK)-associated retinitis pigmentosa, preferentially affect distinct topographic ...
Tucker, Budd A., Wagner, Alex H., Zeng, Shemin, Stone, Edwin M., Braun, Terry A., Scheetz, Todd E., Drack, Arlene V., Whitmore, S. Scott, DeLuca, Adam P., Mullins, Robert F.   +9 more
core   +1 more source

Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar)

Journal of Fish Diseases, EarlyView.
ABSTRACT Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation‐mediated infection assay and histological and ...
Emily Mahon, Rebecca R. Kwabiah, Hélène Paradis, Manuel A. Soto‐Dávila, Sathees Duglas, Raja Ram Gurung, Thurka Paramanathan, Ignacio Vasquez, Shams Al‐Badoosh, John Law, Javier Santander, Mark D. Fast, Robert L. Gendron   +12 more
wiley   +1 more source

Single cell analysis of the developing and adult uveal tract reveals stromal and immune populations of relevance to the spectrum of uveal diseases

The eye is a highly complex organ, in which miniscule deviations from baseline homeostasis can have profound impacts on vision. The uveal tract is a pigmented layer within the eye, with vital supportive roles for the function of the eye. Perturbations of
Reekie, Ian
core   +1 more source