Results 111 to 120 of about 48,314 (255)

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Preeclampsia‐derived small extracellular vesicles disrupt blood–brain barrier integrity and activate glial cells in vitro

The Journal of Physiology, EarlyView.
Abstract figure legend This study assessed the impact of plasma‐derived small extracellular vesicles (sEVs) from healthy pregnant women and those diagnosed with late‐onset preeclampsia (PE) on the blood–brain barrier (BBB) integrity and glial cell response. PE patients had higher sEV concentrations than healthy controls.
Julián Henao‐Restrepo, José M. Murrieta‐Coxca, Christian Schmeer, Lingyu Wei, Frank Steiniger, Tanja Groten, Udo R. Markert, Diana M. Morales‐Prieto   +7 more
wiley   +1 more source

HierAnom‐Path: Zero‐Shot Rare Cancer Detection in Histopathology via Hierarchical Foundation Model Adaptation

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Rare cancers collectively represent 20%–25% of all malignancies yet yield fewer than 50 annotated whole‐slide images (WSIs) per subtype in publicly available archives, rendering supervised deep learning inapplicable. We present HierAnom‐Path, to the best of our knowledge, the first framework for zero‐shot rare cancer anomaly detection in ...
Noora Saleem Jumaah, Mohanad Sameer Jabbar, Saif H. Alwaeli, Noor Ayesha, Mohamed Babiker A. Mohamed, Muhammad I. Khan   +5 more
wiley   +1 more source

Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile

Annals of Neurology, Volume 100, Issue 2, Page 255-267, August 2026.
Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale, Arkadiusz Nawrocki, Johanne J. Korsbæk, Nadja S. Hansen, Fabian Foettinger, Nik Krajnc, Mathias J. Norvig, Niclas L. Eriksen, Stefan Macher, Berthold Pemp, Connar S.J. Westgate, Christian B. Pedersen, Frantz R. Poulsen, Sune Munthe, Gabriel Bsteh, Martin R. Larsen, Rigmor H. Jensen, Dagmar Beier   +17 more
wiley   +1 more source

A Novel Slit Lamp‐Based System for 3D Ultrasound of the Eye

Journal of Ultrasound in Medicine, Volume 45, Issue 8, Page 1695-1706, August 2026.
Objectives This study aims to develop and evaluate a novel slit‐lamp‐based system to acquire 3‐dimensional (3D) ultrasound volumes using conventional ultrasound probes. Methods A slit‐lamp adapter was 3D printed and connected with a linear actuator and graphical user interface (GUI) system to control movement and create volumes of 2‐dimensional scans ...
Claire E. Malley, Joseph P. Miller, Boyan Pan, Josiah K. To, Jack O. Thomas, Steven Y. Chang, Jason Dagoon, William C. Tang, Parsa Riazi Esfahani, Andrew W. Browne   +9 more
wiley   +1 more source

Non-Infectious Choroiditis Subdivided into Its Diverse Pathophysiological Sub-Groups Is the Best-Known and Most Appropriate Nomenclature to Date for the Reclassification and Diagnosis of Former White Dot Entities. [PDF]

Diagnostics (Basel)
Herbort CP, Silpa-Archa S, Papasavvas I, Bouchenaki N, Byszewska A, Dorokhova O, Fardeau C, Hedayatfar A, Hwang DK, Lages V, Lo WJ, Papadia M, Takeuchi M, Usui Y, Yanai R, Zborovska O.   +15 more
europepmc   +1 more source

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun, Linqing Wen, Shiyun Tang, Lu Liu, Nianzhi Chen   +4 more
wiley   +1 more source

Cellular expression domains of type 3 deiodinase in the meninges, choroid plexus, tanycytes and barrier tissues of the brain. [PDF]

Front Endocrinol (Lausanne)
Liu Y, Ng L, Liu H, Forrest D.
europepmc   +1 more source

Task‐Evoked Functional Activation and Coupling With CSF Flow Detected in the Human Brain With Ultrashort Echo Time fMRI at 7 T

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
Ultrashort and zero echo time (UTE and ZTE) MRI techniques generate functional contrast through inflow effects, making them suitable for studying cerebral blood flow and cerebrospinal fluid (CSF) dynamics. In a 7‐T study of 13 participants performing a visual task, we demonstrate that UTE produced robust, reproducible activations with group‐level ...
Sara Ponticorvo, Ekaterina Paasonen, Pavel Filip, Douglas L. Rothman, Juha S. Valjakka, Olli Gröhn, Shalom Michaeli, Silvia Mangia   +7 more
wiley   +1 more source

Variability in the circulation of cerebrospinal fluid: causes and clinical implications for intraventricular drug delivery. [PDF]

Front Drug Deliv
Engelhard HH, Balédent O, Borzage MT, Andrews-Jones L, Feldsien TM, Lefebvre DR.   +5 more
europepmc   +1 more source