Results 111 to 120 of about 2,173,247 (301)

Microglia Ablation and Downstream Effects in the Cerebrospinal Fluid Proteome

PROTEOMICS, EarlyView.
ABSTRACT Disease‐related activation of glial cells leads to changes in the cerebrospinal fluid (CSF) proteome. However, assigning such protein changes to their cellular origins is often difficult. Here, we used microglia (and macrophage) depletion in mice to identify CSF proteins of microglial origin.
Sinja Buchner, Sihui Song, Stephan A. Müller, Yun Chen, Samira Parhizkar, Stefan F. Lichtenthaler, David M. Holtzman, Mathias Jucker, Stephan A. Kaeser   +8 more
wiley   +1 more source

Clinical outcomes of cyclophosphamide therapy in relentless placoid choroiditis: A descriptive case series

Indian Journal of Ophthalmology
Purpose: To describe the clinical presentation and visual outcomes of relentless placoid choroiditis (RPC) in four patients treated with intravenous cyclophosphamide, a treatment not extensively studied in this condition.
Miguel Pedroza-Seres, Carlos E Rodríguez-López   +1 more
doaj   +1 more source

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

Clinical reasoning in feline non‐ambulatory tetraparesis or tetraplegia: Which combination of clinical information is useful?

Veterinary Record, EarlyView.
Abstract Background Non‐ambulatory tetraparesis or tetraplegia in cats may constitute a diagnostic challenge for general practitioners. Therefore, this study aimed to evaluate if clinical variables from signalment, history, clinical examination and basic ancillary tests are associated with underlying diagnoses in cats with non‐ambulatory tetraparesis ...
Guido Bertoldi, Steven De Decker
wiley   +1 more source

Chronic diseases in Australia: blueprint for preventive action [PDF]

, 2015
This paper identifies strategic priorities for taking action to prevent chronic diseases. It is the second report by the Mitchell Institute on this issue.
Sharon Willcox, Willcox, Sharon
core  

Spotlight commentary: Addressing the persistent problem of benzodiazepine overuse, time for clinical, educational and AI‐driven reform

British Journal of Clinical Pharmacology, EarlyView.
Jakša Vukojević, Luka Horvat, Vito Papić, Andrija Štajduhar   +3 more
wiley   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Choroidal metastases from thoracic cancer: a retrospective study on clinical characteristics and treatment efficacy

Frontiers in Medicine
ObjectiveThis study aimed to examine the clinical characteristics of choroidal metastases (CMs) and assess the efficacy of various treatment strategies for CMs in a specific patient cohort.MethodsThis retrospective case series study included 32 patients (
Xiacheng Lin, Yusheng Zhong, Haiping Li, Yating Yang, Ahui Liu, Yajing Shi, Jianhong Liang, Yong Cheng   +7 more
doaj   +1 more source

Immunohistochemical analysis of CDX2 expression in normal choroid plexus epithelium and choroid plexus tumors [PDF]

, 2009
Background: The Wnt and BMP signaling pathways are involved in the morphogenesis of both gastrointestinal and choroid plexus epithelium. In the intestine, Wnt signaling represses the expression of the tumor suppressor gene CDX2 via SOX9, a ...
Mugler, M., Beschorner, R., Meyermann, R., Schittenhelm, J., Mittelbronn, M.   +4 more
core  

Perceptual-Assisted Adversarial Adaptation for Choroid Segmentation in Optical Coherence Tomography

, 2020
Accurate choroid segmentation in optical coherence tomography (OCT) image is vital because the choroid thickness is a major quantitative biomarker of many ocular diseases.
Zhou, Kang, Jiang Liu, Jianlong Yang, Ma, Yuhui, Gao, Shenghua, Yuhui Ma, Yang, Jianlong, Chen, Zhi, Shenghua Gao, Zhi Chen, Liu, Jiang, Kang Zhou, Zhenjie Chai, Chai, Zhenjie   +13 more
core   +1 more source