Results 111 to 120 of about 70,682 (288)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Choroidal biomarkers

Indian Journal of Ophthalmology, 2018
A structurally and functionally intact choroid tissue is vitally important for the retina function. Although central retinal artery is responsible to supply the inner retina, choroidal vein network is responsible for the remaining one-third of the ...
Francesco Pichi, Kanika Aggarwal, Piergiorgio Neri, Paola Salvetti, Andrea Lembo, Paolo Nucci, Chui Ming Gemmy Cheung, Vishali Gupta   +7 more
doaj   +1 more source

Effect of Uveal Melanocytes on Choroidal Morphology in Rhesus Macaques and Humans on Enhanced-Depth Imaging Optical Coherence Tomography. [PDF]

, 2016
PurposeTo compare cross-sectional choroidal morphology in rhesus macaque and human eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) and histologic analysis.MethodsEnhanced-depth imaging-OCT images from 25 rhesus macaque and 30 ...
Cunefare, David, Farsiu, Sina, Garzel, Laura, Oltjen, Sharon, Roberts, Jeffrey, Thomasy, Sara M, Vuong, Vivian S, Yiu, Glenn   +7 more
core   +1 more source

Research status and trends of Piezo1 and brain: A bibliometric analysis

Neuroprotection, EarlyView.
This graphical abstract illustrates the workflow and key findings of the bibliometric analysis of Piezo1 in brain research. The primary results were visually centered on a brain graphic highlighting the Piezo1 channel, and three converging research hotspots were identified: neurovascular regulation, calcium signaling, and neuroinflammation.
Yu Liu, Shengzhen Luo, Hao Zhang, Jianqing Lin, Hui Xiao, Yuying Ma, Dongxue Ye, Liang Cong, Yongwang Li   +8 more
wiley   +1 more source

Factors associated with extended remission in neovascular age-related macular degeneration on pro re nata treatment protocol. [PDF]

, 2020
AimTo show the characteristics and outcomes of patients with neovascular age-related macular degeneration (nAMD) who had extended remission (ER) while on a pro re nata (PRN) treatment protocol.MethodsThis was a retrospective case-control study of a ...
Amador-Patarroyo, Manuel J, Cheng, Lingyun, Dans, Kunny C, Freeman, William R, Lin, Tiezhu, Meshi, Amit, Muftuoglu, Ilkay Kilic   +6 more
core  

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

CHARACTERISTICS OF INDIVIDUALS UNDERGOING PANEL GENETIC TESTING FOR PRIMARY BRAIN TUMORS [PDF]

, 2018
Background. Currently, there are no genetic testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution.
Azam, Sarah
core   +1 more source

Moderate Diagnostic Yield of Exome Sequencing in Fetal Growth Restriction: Retrospective Insights

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To determine whether invasive genetic testing should be systematically proposed in cases of FGR. Methods Descriptive retrospective study of 159 FGR cases (defined by an estimated fetal growth < 3rd percentile, regardless of Doppler findings) managed at the Toulouse Fetal Medicine Center (TFMC) during 2022–2023.
Maud Langeois, Louise Paret, Jacqueline Aziza, Paul Guerby, Christophe Vayssière, Charlotte Dubucs   +5 more
wiley   +1 more source

Deep Learning–Based Segmentation of Fetal Anatomical Structures in the First Trimester

Prenatal Diagnosis, EarlyView.
ABSTRACT Objectives To develop and evaluate an artificial intelligence (AI) system that automatically identifies and classifies the fetal structures in the first trimester. Method Over 20,000 ultrasound images from first‐trimester fetuses were prospectively collected from four university hospitals in the Republic of Korea.
Subeen Hong, Oyoung Kim, Byung Soo Kang, Sangeun Won, Hyun Sun Ko, Ji Hea Byun, Jeong Ha Wie, Ji Young Kwon, Kyung Eun Lee, Jae Eun Shin, Yeon Hee Kim, Jaehong Lee, Kwang Yeon Choi, In Yang Park   +13 more
wiley   +1 more source

Multicompartmental poroelastic modelling for CSF production and circulation [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Byrne, J, Tully, B, Vardakis, JC, Ventikos, Y   +4 more
core