Results 101 to 110 of about 48,314 (255)

Neural modulation of ocular immunity: Exploring a sympathetic‐macrophage neuroimmune link in the human ciliary body

Journal of Anatomy, EarlyView.
Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou, Claire Mackaaij, Mark van Zijverden, Hendrik A. Messal, Jeannette Ossewaarde‐van Norel, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +6 more
wiley   +1 more source

The Beijing angle closure progression study: design and methodology

Frontiers in Medicine
PurposeThe purpose of this study is to summarize the design and methodology of a large-scale trial in northern China, the Beijing Angle Closure Progression Study (BAPS).
Zhi-qiao Liang, Zhi-qiao Liang, Kang-yi Yang, Kang-yi Yang, Kun Lv, Kun Lv, Yao Ma, Yao Ma, Cun Sun, Ge Liang, Yan-kun Yue, Jia-yin Qin, Yao Zhao, Jia-nan Zhang, Qiong Yi, Xing-zhi Sun, Hui-juan Wu, Hui-juan Wu   +17 more
doaj   +1 more source

Targeting progressive multiple sclerosis: Toward mechanism‐informed precision medicine

Journal of Internal Medicine, EarlyView.
Abstract Multiple sclerosis has undergone a therapeutic revolution over the past three decades. Randomized clinical trials and real‐world data demonstrate that modern disease‐modifying therapies substantially reduce relapse rates and acute inflammatory activity detected by magnetic resonance imaging (MRI).
Fredrik Piehl, Gonçalo Castelo‐Branco, Maja Jagodic, Tomas Olsson   +3 more
wiley   +1 more source

Pharmacokinetics of Diclazuril in the Plasma and Cerebrospinal Fluid of Healthy Adult Horses After a Single Oral Dose Administered as a Pelleted Topdressing

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Equine protozoal myeloencephalitis can cause acute infections with rapid onset of neurologic signs, necessitating immediate empiric therapy with antiprotozoal medication. The objective of the study was to identify when concentrations of diclazuril reached the MIC of Sarcocystis neurona in CSF (1 ng/mL) of healthy adult horses after a single ...
Elizabeth J. Treece, Kate L. Hepworth‐Warren, Mark G. Papich, Philip D. van Harreveld, Anthony T. Blikslager, Faith E. Church, Kaitlyn B. Harbor, Sara J. Erwin‐Craig   +7 more
wiley   +1 more source

Stability of Cerebrospinal Fluid Proteins in Dogs and Cats: Effects of Refrigeration and Freezing Over Time

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background The quantification of protein levels is an important part of standard cerebrospinal fluid (CSF) analysis. However, delays in processing due to shipment and/or laboratory opening schedules, combined with the need to preserve sample stability during storage, pose critical challenges to ensuring accurate diagnoses.
Luana S. Ribeiro, Aude Castel, Bruno B. J. Torres   +2 more
wiley   +1 more source

Techniques for subretinal injections in animals

Veterinary Ophthalmology, Volume 28, Issue 2, Page 506-518, March 2025.
Abstract Subretinal injections are not commonly performed during clinical treatment of animals but are frequently used in laboratory animal models to assess therapeutic efficacy and safety of gene and cell therapy products. Veterinary ophthalmologists are often employed to perform the injections in the laboratory animal setting, due to knowledge of ...
Ryan F. Boyd, Simon M. Petersen‐Jones
wiley   +1 more source

An eye on long‐duration spaceflight: Controversies, countermeasures and challenges

Experimental Physiology, EarlyView.
Abstract Space flight‐associated neuroocular syndrome (SANS) is a consequence of long‐duration space flight and is detected in two‐thirds of astronauts. In‐flight, this can cause a change in the refraction of the eyes, requiring graded hypermetropic ‘superfocus adjustable’ glasses, optic nerve head oedema and choroidal folds.
Vincent Wing Sum Ng, Susan Patricia Mollan   +1 more
wiley   +1 more source

A 51‐year‐old female presenting with headache and vision loss

Headache: The Journal of Head and Face Pain, EarlyView.
Laurel Ovrom, Zachary Pardieck, Randy Christopher Bowen, Neena R. Cherayil   +3 more
wiley   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source