Results 151 to 160 of about 2,322,168 (296)

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Zinc and Eye Diseases

, 2011
The eye, especially the retina and the underlying retinal pigment epithelium/choroid complex, contain high concentrations of zinc. Therefore, it is not surprising that several eye disorders are associated with altered zinc balance, and zinc ...
Lengyel, Imre; id_orcid, Peto, Tunde; id_orcid, Cahyadi, Sabrina, Barzegar-Befroei, Neda, Gango, Ashraf   +4 more
core   +1 more source

Choroid plexus carcinoma: Report of two cases

, 2009
Choroid plexus carcinomas (CPCs) are rare malignant counterparts of choroid plexus papilloma which occur in infants and children with a predilection for the posterior fossa and have a poor prognosis.
Shruti Sharma, Singh Avninder, Vermani Sarvjot   +2 more
core  

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

What we can learn about biology from monogenic diseases; KIF11 and the glymphatic and lymphatic-like system of the retina and choroid and its possible role in the pathogenesis of pachychoroid and central serous chorioretinopathy. [PDF]

Int J Retina Vitreous
Pulido JS, Arevalo JF, Farrell LC, Muste JC.   +3 more
europepmc   +1 more source

Preeclampsia‐derived small extracellular vesicles disrupt blood–brain barrier integrity and activate glial cells in vitro

The Journal of Physiology, EarlyView.
Abstract figure legend This study assessed the impact of plasma‐derived small extracellular vesicles (sEVs) from healthy pregnant women and those diagnosed with late‐onset preeclampsia (PE) on the blood–brain barrier (BBB) integrity and glial cell response. PE patients had higher sEV concentrations than healthy controls.
Julián Henao‐Restrepo, José M. Murrieta‐Coxca, Christian Schmeer, Lingyu Wei, Frank Steiniger, Tanja Groten, Udo R. Markert, Diana M. Morales‐Prieto   +7 more
wiley   +1 more source

Atypical Ectopic Choroid Plexus Papilloma - Not so Benign

, 2019
Choroid plexus papillomas (CPP) are rare neoplasms (0.4-0.6% of all brain tumors) arising from cuboidal epithelial cells of the choroid plexus. We describe an adult with a rare atypical ectopic choroid plexus papilloma in the cerebellopontine angle with ...
Rooshil Patel; Douglas Lukins; John Villano; Padmaja Sudhakar
core  

Discovery of a First‐in‐Class Dual‐Function TLX Activator by Microscale Library Synthesis and Direct‐to‐Biology Screening

Angewandte Chemie Novit, Volume 2, Issue 4, December 2026.
The transcription factor tailless (TLX) is an orphan nuclear receptor thought to maintain neural and retinal stem cell populations in a proliferating state to enable regeneration. Ligands to study TLX modulation were lacking. We developed a potent TLX agonist capable of activating TLX's transcriptional repressor and activator properties in an evolution‐
Tanja Stiller, Romy Busch, Giuseppe Faudone, Felia C. Haffelder, Jan Vietor, Arthur Kardanov, Úrsula López‐García, Arne Hackspacher, Georg Höfner, Vasily Morozov, Susanne F. Koch, Julian A. Marschner, Daniel Merk   +12 more
wiley   +1 more source

Ocular safety of subconjunctival injection of tacrolimus in rabbits. [PDF]

BMC Ophthalmol
Hassanin Z, Shama A, Zakaria N, Mohalhal IA, Awad M, Zaki I, Elmetwally AA, Shoughy S.   +7 more
europepmc   +1 more source