Results 61 to 70 of about 49,505 (301)

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Choroid sprouting assay: an ex vivo model of microvascular angiogenesis. [PDF]

, 2013
Angiogenesis of the microvasculature is central to the etiology of many diseases including proliferative retinopathy, age-related macular degeneration and cancer.
Jing Chen, Zhenghao Cui (438233), Aimee M. Juan (189067), Jean-Sébastien Joyal (438238), Zhuo Shao, Sylvain Chemtob (64438), Aimee M Juan, Mollie Friedlander, François Duhamel (438237), Lucy P Evans, Houda Tahir (438236), Jing Chen (4762), Przemyslaw Sapieha (102700), Sylvain Chemtob, François Duhamel, Jean-Sébastien Joyal, Lois E. H. Smith (102715), Christian G. Hurst (438232), Zhenghao Cui, Dorothy T. Pei (438234), Lucy P. Evans (438235), Christian G Hurst, Dorothy T Pei, Przemyslaw Sapieha, Lois E H Smith, Mollie Friedlander (438231), Zhuo Shao (438230), Houda Tahiri   +27 more
core   +2 more sources

QUANTITATIVE ANALYSIS OF STRUCTURAL ALTERATIONS IN THE CHOROID OF PATIENTS WITH ACTIVE BEHÇET UVEITIS

, 2018
Purpose: To quantitatively analyze in vivo morphology of subfoveal choroid during an acute attack of Behcet ...
Herbort, C.P., Uludag, Gunay, Gunay Uludag, Uludag, G., Merih Oray, Akbay, Aylin Koc, Sumru Onal, Ilknur Tugal-Tutkun, Aylin Koc Akbay, Onal, Sumru, Metin, Mustafa M., Metin, M.M., Herbort, Carl P., Carl P. Herbort, Emre Mengi, Akman, M., Mengi, Emre, Mengi, E., Tugal-Tutkun, Ilknur, Onal, S., Mehmet Akman, Tugal-Tutkun, I., Mustafa M. Metin, Oray, M., Oray, Merih, AKMAN, MEHMET, Koc Akbay, A.   +26 more
core   +1 more source

Glucose, Fructose, and Urate Transporters in the Choroid Plexus Epithelium

, 2020
The choroid plexus plays a central role in the regulation of the microenvironment of the central nervous system by secreting the majority of the cerebrospinal fluid and controlling its composition, despite that it only represents approximately 1% of the ...
Masaki Ueno, Yoichi Chiba, Keiji Wakamatsu, Naoya Uemura, Wakako Nonaka, Koichi Matsumoto, Masaki Kamada, Ryuta Murakami, Ken Yanase   +8 more
core   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Low‐contrast visual acuity versus low‐luminance visual acuity in choroideremia

Clinical and Experimental Optometry, EarlyView., 2020
Clinical relevance Choroideremia is a progressive X‐linked inherited rod‐cone dystrophy. Patients present with nyctalopia and progressive visual field loss, but visual acuity remains well preserved early on. This study showed that low‐luminance visual acuity may be a useful clinical outcome measure during earlier disease stages.
Laura J Wood, Jasleen K Jolly, Colm D Andrews, Iain R Wilson, Doron Hickey, Jasmina Cehajic‐Kapetanovic, Robert E MacLaren   +6 more
wiley   +1 more source

Normal growth curve of choroid plexus in children: implications for assessing hydrocephalus due to choroid plexus hyperplasia [PDF]

Hashimoto H., Takemoto O., Nishimoto K., et al. Normal growth curve of choroid plexus in children: implications for assessing hydrocephalus due to choroid plexus hyperplasia.
Moriguchi, Gento, Nakamura, Motoki, Hashimoto, Hiroaki, Takemoto, Osamu, Chiba, Yasuyoshi, Nishimoto, Keisuke   +5 more
core   +1 more source

Examining the Choroid in Ocular Inflammation: A Focus on Enhanced Depth Imaging [PDF]

, 2014
The choroid is the vascular layer that supplies the outer retina and is involved in the pathogenesis of several ocular conditions including choroidal tumors, age related macular degeneration, central serous chorioretinopathy, diabetic retinopathy, and ...
Sue Lightman, Abeir Baltmr, Oren Tomkins-Netzer   +2 more
core   +1 more source

Clinical, Behavioral and Neuroradiological Phenotype in an Italian Cohort of Patients With Xia Gibbs Syndrome: A Multicenter Cross‐Sectional Study and Systematic Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous variants in the AHDC1 gene are associated with Xia Gibbs Syndrome (XGS), a genetic disorder with a highly variable phenotype. Cognitive impairment, motor delay, language delay, neonatal hypotonia, and sleep apnea are considered “cardinal” signs of the disease.
Giulia Cinelli, Stefania Della Vecchia, Patrizia Bergonzini, Elisa Caramaschi, Elisabetta Spezia, Claudia Parenti, Simona Filomena Madeo, Laura Lucaccioni, Cavalleri Francesca, Marisa Pugliese, Federico Raviglione, Clara Colonna, Olga Calabrese, Ilaria Stanghellini, Maria Carmen Marongiu, Enrico Biagioni, Anna Rita Ferrari, Roberta Battini, Lorenzo Iughetti   +18 more
wiley   +1 more source