Results 11 to 20 of about 991,372 (400)
Topological domains in mammalian genomes identified by analysis of chromatin interactions
Nature, 2012 The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete.
Jesse R Dixon +2 more
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Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]
Nature, 2017 Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Zhixun Dou +23 more
semanticscholar +4 more sources
Synaptic, transcriptional and chromatin genes disrupted in autism
Nature, 2014 The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937 ...
Mark Joseph Daly +2 more
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The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Nature Reviews Molecular Cell Biology, 2017 Arnab Ray Chaudhuri
exaly +2 more sources
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Nature, 2007 Tarjei S Mikkelsen +2 more
exaly +2 more sources
Fun30 and Rtt109 Mediate Epigenetic Regulation of the DNA Damage Response Pathway in C. albicans
Journal of Fungi, 2022 Fun30, an ATP-dependent chromatin remodeler from S. cerevisiae, is known to mediate both regulation of gene expression as well as DNA damage response/repair. The Fun30 from C. albicans has not yet been elucidated. We show that C.
Prashant Kumar Maurya +10 more
doaj +1 more source
Current Biology, 2015 Chromatin is a complex of proteins, RNA and DNA that constitutes the physiological state of the genome. Its basic structure is essentially the same in nearly all eukaryotes, from single-celled yeasts to the most complex multicellular organisms (exceptions include the chromatin of dinoflagellates and vertebrate sperm). Its fundamental role is to package
Gross, David S. +3 more
openaire +3 more sources
Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice
Nature Communications, 2021 Misregulation of chromatin has been linked to many conditions, including obesity, but the details remain unclear. Here the authors identify the H4 lysine 16 acetyltransferase MOF as a master regulator of glucose metabolism that is required for normal ...
Cecilia Pessoa Rodrigues +6 more
doaj +1 more source
Journal of Medical Genetics, 1964 Publisher Summary The term “sex chromatin,― denotes a body in the nuclei of cells, which shows a special relationship to the sex of the organism from which the cell originated. The sex-chromatin body is present in the nucleus only during interphase and disappears during mitosis.
Ursula Mittwoch
openalex +5 more sources
Chromatin Boundaries and Chromatin Domains [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2004 Insulator elements were first described in Drosophila, but subsequent studies have shown that they are present in vertebrates as well (for review, see West et al. 2002). Over the past several years we have focused our attention on the properties of an insulator at the 5énd of the chicken β-globin locus that has begun to provide an understanding of how ...
Felsenfeld, G. +13 more
openaire +3 more sources