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Current Biology, 2015 Chromatin is a complex of proteins, RNA and DNA that constitutes the physiological state of the genome. Its basic structure is essentially the same in nearly all eukaryotes, from single-celled yeasts to the most complex multicellular organisms (exceptions include the chromatin of dinoflagellates and vertebrate sperm). Its fundamental role is to package
Gross, David S. +3 more
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Chromatin Unlimited: An Evolutionary View of Chromatin [PDF]
Epigenomes, 2022 Chromatin is a fundamental and highly conserved structure that carries genetic and epigenetic information in eukaryotic cells [...]
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Chromatin Boundaries and Chromatin Domains [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2004 Insulator elements were first described in Drosophila, but subsequent studies have shown that they are present in vertebrates as well (for review, see West et al. 2002). Over the past several years we have focused our attention on the properties of an insulator at the 5énd of the chicken β-globin locus that has begun to provide an understanding of how ...
Felsenfeld, G. +13 more
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Chromatin Loop Extrusion and Chromatin Unknotting [PDF]
Polymers, 2018 It has been a puzzle how decondensed interphase chromosomes remain essentially unknotted. The natural expectation is that in the presence of type II DNA topoisomerases that permit passages of double-stranded DNA regions through each other, all chromosomes should reach the state of topological equilibrium.
Racko, Dusan +3 more
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TelNet - a database for human and yeast genes involved in telomere maintenance
BMC Genetics, 2018 Background The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery.
Delia M. Braun +4 more
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Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. [PDF]
, 2017 BackgroundProper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development, leading to ...
Brayman, Melissa J +6 more
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Bio-Protocol, 2021 β-hemoglobinopathies are severe genetic disorders characterized either by the abnormal synthesis of the adult β-globin chains of the hemoglobin (Hb) tetramer (βS-globin chains) in sickle cell disease (SCD) or by the reduced β-globin production in β ...
Anne Chalumeau +3 more
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ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Dimitrov S. +6 more
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Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts [PDF]
, 2001 Oncoprotein 18 (Op18) is a microtubule-destabilizing protein that is negatively regulated by phosphorylation. To evaluate the role of the three Op18 phosphorylation sites in Xenopus (Ser 16, 25, and 39), we added wild-type Op18, a nonphosphorylatable ...
Andersen +67 more
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Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]
, 1996 In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M. +3 more
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