Results 21 to 30 of about 496,209 (318)
Nature Communications, 2023 Rhodamines are privileged fluorescent dyes for labelling intracellular structures in living cells. Here, the authors present a facile protecting-group-free synthesis permitting generation of a wide range of symmetrical and unsymmetrical 4 ...
Jonas Bucevičius +6 more
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TelNet - a database for human and yeast genes involved in telomere maintenance
BMC Genetics, 2018 Background The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery.
Delia M. Braun +4 more
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Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1
Nature Communications, 2022 The mechanism by which RNAPII transcribes the DNA in the chromatosome with H1 has remained enigmatic. Here the authors present the cryo-EM structures of the RNAPII-chromatosome complexes, and explain how RNAPII is regulated by H1 in chromatin.
Rina Hirano +6 more
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Targeting the Nucleosome Acidic Patch by Viral Proteins: Two Birds with One Stone?
mBio, 2022 The past decade illuminated the H2A-H2B acidic patch as a cornerstone for both nucleosome recognition and chromatin structure regulation. Higher-order folding of chromatin arrays is mediated by interactions of histone H4 tail with an adjacent nucleosome ...
Floriane Lagadec +2 more
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Annual Review of Biophysics, 2010 The expression patterns of many protein-coding genes are orchestrated in response to exogenous stimuli, as well as cell-type-specific developmental programs. In recent years, researchers have shown that dynamic chromatin movements and interactions in the nucleus play a crucial role in gene regulation.
Michael R, Hübner, David L, Spector
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Bio-Protocol, 2021 β-hemoglobinopathies are severe genetic disorders characterized either by the abnormal synthesis of the adult β-globin chains of the hemoglobin (Hb) tetramer (βS-globin chains) in sickle cell disease (SCD) or by the reduced β-globin production in β ...
Anne Chalumeau +3 more
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Biophysical Journal, 2014 Following recent observations of large scale correlated motion of chromatin inside the nuclei of live differentiated cells, we present a hydrodynamic theory-the two-fluid model-in which the content of a nucleus is described as a chromatin solution with the nucleoplasm playing the role of the solvent and the chromatin fiber that of a solute. This system
Bruinsma, Robijn +3 more
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Epigenetics & Chromatin, 2018 Background Linker histones establish and maintain higher-order chromatin structure. Eleven linker histone subtypes have been reported in mammals. HILS1 is a spermatid-specific linker histone, and its expression overlaps with the histone–protamine ...
Laxmi Narayan Mishra +6 more
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Stem Cells International, 2021 Transposable elements (TEs) are mobile genetic sequences capable of duplicating and reintegrating at new regions within the genome. A growing body of evidence has demonstrated that these elements play important roles in host genome evolution, despite ...
Yixuan Low +4 more
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Microbial Cell, 2023 Enhanced levels of acetic acid reduce the activity of yeast strains employed for industrial fermentation-based applications. Therefore, unraveling the genetic factors underlying the regulation of the tolerance and sensitivity of yeast towards acetic acid
Nitu Saha +2 more
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