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Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver
Molecular Systems Biology, 2022 Regulation of gene expression is linked to the organization of the genome. With age, chromatin alterations occur on all levels of genome organization, accompanied by changes in the gene expression profile.
Mihaela Bozukova +5 more
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ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis
Nature Genetics, 2021 The advent of single-cell chromatin accessibility profiling has accelerated the ability to map gene regulatory landscapes but has outpaced the development of scalable software to rapidly extract biological meaning from these data.
Jeffrey M. Granja +7 more
semanticscholar +1 more source
Chromatin Loop Extrusion and Chromatin Unknotting [PDF]
Polymers, 2018 It has been a puzzle how decondensed interphase chromosomes remain essentially unknotted. The natural expectation is that in the presence of type II DNA topoisomerases that permit passages of double-stranded DNA regions through each other, all chromosomes should reach the state of topological equilibrium.
Racko, Dusan +3 more
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Chromatin Unlimited: An Evolutionary View of Chromatin [PDF]
Epigenomes, 2022 Chromatin is a fundamental and highly conserved structure that carries genetic and epigenetic information in eukaryotic cells [...]
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Frontiers in Cell and Developmental Biology, 2023 In vitro cell line model systems are essential in supporting the research community due to their low cost, uniform culturing conditions, homogeneous biological resources, and easy experimental design to study the cause and effect of a gene or a molecule.
Jhinuk Basu +14 more
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Epigenetics & Chromatin, 2021 Background H1T2/H1FNT is a germ cell-specific linker histone variant expressed during spermiogenesis specifically in round and elongating spermatids. Infertile phenotype of homozygous H1T2 mutant male mice revealed the essential function of H1T2 for the ...
Vasantha Shalini +4 more
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Biophysical Journal, 2014 Following recent observations of large scale correlated motion of chromatin inside the nuclei of live differentiated cells, we present a hydrodynamic theory-the two-fluid model-in which the content of a nucleus is described as a chromatin solution with the nucleoplasm playing the role of the solvent and the chromatin fiber that of a solute. This system
Bruinsma, Robijn +3 more
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Biotechnology & Biotechnological Equipment, 2021 In the recent years, the application of new antitumor drugs has focused on the replacement of conventional chemotherapeutics with compounds derived from natural products.
Jordana Todorova +4 more
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Regulation of the SUV39H Family Methyltransferases: Insights from Fission Yeast
Biomolecules, 2023 Histones, which make up nucleosomes, undergo various post-translational modifications, such as acetylation, methylation, phosphorylation, and ubiquitylation. In particular, histone methylation serves different cellular functions depending on the location
Rinko Nakamura, Jun-ichi Nakayama
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Nature Communications, 2023 Rhodamines are privileged fluorescent dyes for labelling intracellular structures in living cells. Here, the authors present a facile protecting-group-free synthesis permitting generation of a wide range of symmetrical and unsymmetrical 4 ...
Jonas Bucevičius +6 more
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