Results 21 to 30 of about 392,110 (289)
Biotechnology & Biotechnological Equipment, 2021 In the recent years, the application of new antitumor drugs has focused on the replacement of conventional chemotherapeutics with compounds derived from natural products.
Jordana Todorova +4 more
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Journal of Theoretical Biology, 1996 Cellular and molecular biological approaches that study eukaryotic gene regulation have led to separate models which describe structure and mechanism with differing precision. Using principles of combinatorial and cooperative interactions inherent in both models, we have extended concepts derived from a "genetic switch" for prokaryotes to a chromatin ...
Bodnar, John W., Bradley, Margaret K.
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Epigenetics & Chromatin, 2021 Background H1T2/H1FNT is a germ cell-specific linker histone variant expressed during spermiogenesis specifically in round and elongating spermatids. Infertile phenotype of homozygous H1T2 mutant male mice revealed the essential function of H1T2 for the ...
Vasantha Shalini +4 more
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Regulation of the SUV39H Family Methyltransferases: Insights from Fission Yeast
Biomolecules, 2023 Histones, which make up nucleosomes, undergo various post-translational modifications, such as acetylation, methylation, phosphorylation, and ubiquitylation. In particular, histone methylation serves different cellular functions depending on the location
Rinko Nakamura, Jun-ichi Nakayama
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Histochemistry and Cell Biology, 2018 The nucleolus as site of ribosome biogenesis holds a pivotal role in cell metabolism. It is composed of ribosomal DNA (rDNA), which is present as tandem arrays located in nucleolus organizer regions (NORs). In interphase cells, rDNA can be found inside and adjacent to nucleoli and the location is indicative for transcriptional activity of ribosomal ...
Christian Schöfer, Klara Weipoltshammer
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Nature Communications, 2023 Rhodamines are privileged fluorescent dyes for labelling intracellular structures in living cells. Here, the authors present a facile protecting-group-free synthesis permitting generation of a wide range of symmetrical and unsymmetrical 4 ...
Jonas Bucevičius +6 more
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Targeting the Nucleosome Acidic Patch by Viral Proteins: Two Birds with One Stone?
mBio, 2022 The past decade illuminated the H2A-H2B acidic patch as a cornerstone for both nucleosome recognition and chromatin structure regulation. Higher-order folding of chromatin arrays is mediated by interactions of histone H4 tail with an adjacent nucleosome ...
Floriane Lagadec +2 more
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Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1
Nature Communications, 2022 The mechanism by which RNAPII transcribes the DNA in the chromatosome with H1 has remained enigmatic. Here the authors present the cryo-EM structures of the RNAPII-chromatosome complexes, and explain how RNAPII is regulated by H1 in chromatin.
Rina Hirano +6 more
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Bio-Protocol, 2021 β-hemoglobinopathies are severe genetic disorders characterized either by the abnormal synthesis of the adult β-globin chains of the hemoglobin (Hb) tetramer (βS-globin chains) in sickle cell disease (SCD) or by the reduced β-globin production in β ...
Anne Chalumeau +3 more
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Common DNA sequence variation influences 3-dimensional conformation of the human genome. [PDF]
, 2019 BACKGROUND:The 3-dimensional (3D) conformation of chromatin inside the nucleus is integral to a variety of nuclear processes including transcriptional regulation, DNA replication, and DNA damage repair.
Chiou, Joshua +12 more
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