Results 31 to 40 of about 452,870 (322)
Essential role of long non-coding RNAs in de novo chromatin modifications: The genomic address code hypothesis [PDF]
Biophysical Reviews Vol. 9, pp. 73-77 (2017), 2017 The epigenome, i.e. the whole of chromatin modifications, is transferred from mother to daughter cells during cell differentiation. When de novo chromatin modifications (establishment or erasure of, respectively, new or pre-existing DNA methylations and/or histone modifications) are made in a daughter cell, however, it has a different epigenome than ...
arxiv +1 more source
Distinct roles of haspin in stem cell division and male gametogenesis
Scientific Reports, 2021 The kinase haspin phosphorylates histone H3 at threonine-3 (H3T3ph) during mitosis. H3T3ph provides a docking site for the Chromosomal Passenger Complex at the centromere, enabling correction of erratic microtubule-chromosome contacts.
Katerina Soupsana +10 more
doaj +1 more source
Chromatin Alterations in Neurological Disorders and Strategies of (Epi)Genome Rescue
Pharmaceuticals, 2021 Neurological disorders (NDs) comprise a heterogeneous group of conditions that affect the function of the nervous system. Often incurable, NDs have profound and detrimental consequences on the affected individuals’ lives.
Marcin Janowski +3 more
doaj +1 more source
Quantifying the mobility of chromatin during embryogenesis: Nuclear size matters [PDF]
arXiv, 2021 Chromatin moves dynamically inside the cell nucleus, and its motion is often correlated with gene functions such as DNA recombination and transcription. A recent study has shown that during early embryogenesis of the nematode, Caenorhabiditis elegans, the chromatin motion markedly decreases. However, the underlying mechanism for this transition has yet
arxiv
Model chromatin flows: numerical analysis of linear and nonlinear hydrodynamics inside a sphere [PDF]
arXiv, 2023 We solve a hydrodynamic model of active chromatin dynamics, within a confined geometry simulating the cell nucleus. Using both analytical and numerical methods, we describe the behavior of the chromatin polymer driven by the activity of motors having polar symmetry, both in the linear response regime as well as in the long-term, fully nonlinear regime ...
arxiv
eLife, 2021 In eukaryotes, paused replication forks are prone to collapse, which leads to genomic instability, a hallmark of cancer. Dbf4-dependent kinase (DDK)/Hsk1Cdc7 is a conserved replication initiator kinase with conflicting roles in replication stress ...
Shalini Aricthota, Devyani Haldar
doaj +1 more source
Adaptive elastic properties of chromatin fiber [PDF]
, 2002 Chromatin is a complex of DNA and specific proteins forming an intermediary level of organization of eukaryotic genomes, between double-stranded DNA and chromosome. Within a generic modeling of the chromatin assembly, we investigate the interplay between the mechanical properties of the chromatin fiber and its biological functions.
arxiv +1 more source
The Texture of Chromatin [PDF]
Cell, 2019 DNA-replication machinery introduces intertwining and supercoiling of DNA strands as it traverses the double helix, which could impede replication and compromise genome stability. A new study in Cell shows that the intrinsic physical properties of chromatin fibers dictate how torsional stress is partitioned to minimize these risks and facilitate DNA ...
David Levens, Fedor Kouzine
openaire +3 more sources
Frontiers in Immunology, 2020 Associations between blood cancer and genetic predisposition, including both inherited variants and acquired mutations and epimutations, have been well characterized.
Llorenç Rovirosa +3 more
doaj +1 more source
Cantharidin downregulates PSD1 expression and inhibits autophagic flux in yeast cells
FEBS Open Bio, 2022 Cantharidin is a terpenoid compound of insect origin, naturally produced by male blister beetles as an antipredatory mechanism. Cantharidin has anticancer properties, which are attributed to its ability to induce cell cycle arrest, DNA damage, MAPK ...
Swati Swagatika, Raghuvir Singh Tomar
doaj +1 more source