Results 31 to 40 of about 971,786 (390)

Crosstalk between chromatin structure, cohesin activity and transcription [PDF]

, 2019
Background: A complex interplay between chromatin and topological machineries is critical for genome architec‑ ture and function. However, little is known about these reciprocal interactions, even for cohesin, despite its multiple roles in DNA metabolism.
Andújar, Eloísa, Barrientos Moreno, Marta, Cabello Lobato, María José, Gómez Marín, Elena, Maya Miles, Douglas, Morillo Huesca, Macarena, Murillo Pineda, Marina, Prado, Félix, Pérez Alegre, Mónica   +8 more
core   +1 more source

Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle

Scientific Reports, 2021
Chromatin configuration influences gene expression in eukaryotes at multiple levels, from individual nucleosomes to chromatin domains several Mb long.
John A. Halsall, Simon Andrews, Felix Krueger, Charlotte E. Rutledge, Gabriella Ficz, Wolf Reik, Bryan M. Turner   +6 more
doaj   +1 more source

Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

Nature, 2010
Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood.
Rajnish A. Gupta, Nilay Shah, Kevin C. Wang, Jeewon Kim, H. Horlings, D. Wong, Miao-Chih Tsai, T. Hung, P. Argani, J. Rinn, Yulei N. Wang, P. Brzoska, Benjamin S. Kong, Rui Li, R. West, M. J. van de Vijver, S. Sukumar, Howard Y. Chang   +17 more
semanticscholar   +1 more source

Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin

Cell, 2020
Cell differentiation and function are regulated across multiple layers of gene regulation, including the modulation of gene expression by changes in chromatin accessibility.
Sai Ma, Bing Zhang, Lindsay M. LaFave, Zachary D. Chiang, Yan Hu, Jiarui Ding, Alison Brack, Vinay K. Kartha, Travis Law, C. Lareau, Y. Hsu, A. Regev, Jason D. Buenrostro   +12 more
semanticscholar   +1 more source

ATP-dependent chromatosome remodeling [PDF]

, 2008
Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Dimitrov S., Langst G., Loyola A., Ner S.S., Shogren-Knaak M., Varga-Weisz P.D., Wisniewski J.R.   +6 more
core   +1 more source

Quantifying nuclear wide chromatin compaction by phasor analysis of histone Förster resonance energy transfer (FRET) in frequency domain fluorescence lifetime imaging microscopy (FLIM) data. [PDF]

, 2020
The nanometer spacing between nucleosomes throughout global chromatin organisation modulates local DNA template access, and through continuous dynamic rearrangements, regulates genome function [1].
Gratton, Enrico, Hinde, Elizabeth, Liang, Zhen, Lou, Jieqiong, Scipioni, Lorenzo   +4 more
core   +3 more sources

Investigation of the acetic acid stress response in Saccharomyces cerevisiae with mutated H3 residues

Microbial Cell, 2023
Enhanced levels of acetic acid reduce the activity of yeast strains employed for industrial fermentation-based applications. Therefore, unraveling the genetic factors underlying the regulation of the tolerance and sensitivity of yeast towards acetic acid
Nitu Saha, Swati Swagatika, Raghuvir Singh Tomar   +2 more
doaj   +1 more source

Chromatin in Multicolor [PDF]

Cell, 2010
Chromatin consists of DNA and a large number of associated proteins. Filion et al. (2010) provide a genome-wide analysis of the location of 53 chromatin proteins in Drosophila, revealing important principles underlying chromatin regulation and providing colorful insights into their organization.
openaire   +3 more sources

Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. [PDF]

, 2010
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes.
Alekseyenko, Artyom A, Bishop, Eric P, Canfield, Theresa K, Elgin, Sarah CR, Ernst, Jason, Gorchakov, Andrey A, Gu, Tingting, Jung, Youngsook L, Karpen, Gary H, Kellis, Manolis, Kharchenko, Peter V, Kuroda, Mitzi I, Larschan, Erica, Linder-Basso, Daniela, Luquette, Lovelace J, MacAlpine, David M, Minoda, Aki, Park, Peter J, Park, Richard W, Pirrotta, Vincenzo, Plachetka, Annette, Riddle, Nicole C, Sabo, Peter J, Sandstrom, Richard, Schwartz, Yuri B, Shanower, Gregory, Stamatoyannopoulos, John A, Thurman, Robert E, Tolstorukov, Michael Y, Xi, Ruibin   +29 more
core   +4 more sources

Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements

Epigenetics & Chromatin, 2018
Background Linker histones establish and maintain higher-order chromatin structure. Eleven linker histone subtypes have been reported in mammals. HILS1 is a spermatid-specific linker histone, and its expression overlaps with the histone–protamine ...
Laxmi Narayan Mishra, Vasantha Shalini, Nikhil Gupta, Krittika Ghosh, Neeraj Suthar, Utsa Bhaduri, M. R. Satyanarayana Rao   +6 more
doaj   +1 more source