Results 31 to 40 of about 834,176 (358)

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. [PDF]

, 2013
Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that
An, Woojin, Awad, Salma, Bai, Yan, Bers, Donald, Kedes, Larry, Kunhi, Muhammad, Little, Gillian H, Poizat, Coralie   +7 more
core   +1 more source

Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites

Scientific Reports, 2017
Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene
Virginia C. Rodríguez-Cortez, Paloma Martínez-Redondo, Francesc Català-Moll, Javier Rodríguez-Ubreva, Antonio Garcia-Gomez, Ganesh Poorani-Subramani, Laura Ciudad, Henar Hernando, Arantxa Pérez-García, Carlos Company, José M. Urquiza, Almudena R. Ramiro, Javier M. Di Noia, Alejandro Vaquero, Esteban Ballestar   +14 more
doaj   +1 more source

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization. [PDF]

, 2014
Vascular endothelial growth factor A (VEGF-A) is a master regulator of angiogenesis, vascular development and function. In this study we investigated the transcriptional regulation of VEGF-A-responsive genes in primary human aortic endothelial cells ...
Benner, Christopher, Glass, Christopher K, Heinz, Sven, Kaikkonen, Minna U, Kansanen, Emilia, Kivelä, Annukka M, Laitalainen, Jarkko, Niskanen, Henri, Romanoski, Casey E, Ylä-Herttuala, Seppo   +9 more
core   +1 more source

Chromatin Dynamics [PDF]

Annual Review of Biophysics, 2010
The expression patterns of many protein-coding genes are orchestrated in response to exogenous stimuli, as well as cell-type-specific developmental programs. In recent years, researchers have shown that dynamic chromatin movements and interactions in the nucleus play a crucial role in gene regulation.
Michael R, Hübner, David L, Spector
openaire   +2 more sources

Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle

Scientific Reports, 2021
Chromatin configuration influences gene expression in eukaryotes at multiple levels, from individual nucleosomes to chromatin domains several Mb long.
John A. Halsall, Simon Andrews, Felix Krueger, Charlotte E. Rutledge, Gabriella Ficz, Wolf Reik, Bryan M. Turner   +6 more
doaj   +1 more source

Candida albicans repetitive elements display epigenetic diversity and plasticity [PDF]

, 2016
Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here,
A Ellahi, A Pidoux, A Selmecki, aF Straight, BD Strahl, C Ketel, C Li, C Trapnell, Ca Froyd, CJ Merrick, D Kadosh, DE Gottschling, GD Shankaranarayana, H Chibana, H Chibana, J Haran, J Huang, J Huang, J Nakayama, J Pérez-Martín, J Wendland, JC Tanny, JS Smith, Ka Morano, KR Hansen, L Vasiljeva, LH Freitas-Junior, LN Rusche, M Bryk, M Bühler, M Dubarry, M Paschini, M Van het Hoog, MA Pfaller, MD De Backer, MJ McEachern, N Saksouk, PA Dumesic, PR Lephart, PR Lephart, R Kaur, RB Wilson, RJ Bennett, S Greiss, S Henikoff, S Imai, S Kueng, S Rea, SI Iwaguchi, T Jones, T Kobayashi, T Kobayashi, T Kouzarides, VM Bruno, W Shou, WS Chu, X Bi   +56 more
core   +1 more source

Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency. [PDF]

, 2018
The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeling ...
Catta-Preta, Rinaldo, Lim, Kenneth, Nord, Alex S, Wade, A Ayanna   +3 more
core   +6 more sources

The Genome in a Three-Dimensional Context: Deciphering the Contribution of Noncoding Mutations at Enhancers to Blood Cancer

Frontiers in Immunology, 2020
Associations between blood cancer and genetic predisposition, including both inherited variants and acquired mutations and epimutations, have been well characterized.
Llorenç Rovirosa, Alberto Ramos-Morales, Biola M. Javierre, Biola M. Javierre   +3 more
doaj   +1 more source

Chromatin Alterations in Neurological Disorders and Strategies of (Epi)Genome Rescue

Pharmaceuticals, 2021
Neurological disorders (NDs) comprise a heterogeneous group of conditions that affect the function of the nervous system. Often incurable, NDs have profound and detrimental consequences on the affected individuals’ lives.
Marcin Janowski, Małgorzata Milewska, Peyman Zare, Aleksandra Pękowska   +3 more
doaj   +1 more source

SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere function in S. cerevisiae [PDF]

, 2011
Budding yeast centromeres are sequence-defined point centromeres and are, unlike in many other organisms, not embedded in heterochromatin. Here we show that Fun30, a poorly understood SWI/SNF-like chromatin remodeling factor conserved in humans ...
Anna T. Vetter, Beth A. Sullivan, Delphine Theodorou, Edoardo Petrini, Felix Krueger, J. Ross Miller, Konrad Paszkiewicz, Margaret R. Crawford, Mickaël Durand-Dubief, Nicholas A. Kent, Patrick Varga-Weisz, Rachael R. Harris, Rosa Maria Correra, William Ryan Will   +13 more
core   +4 more sources