Results 31 to 40 of about 496,209 (318)
Distinct roles of haspin in stem cell division and male gametogenesis
Scientific Reports, 2021 The kinase haspin phosphorylates histone H3 at threonine-3 (H3T3ph) during mitosis. H3T3ph provides a docking site for the Chromosomal Passenger Complex at the centromere, enabling correction of erratic microtubule-chromosome contacts.
Katerina Soupsana +10 more
doaj +1 more source
Scientific Reports, 2017 Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene
Virginia C. Rodríguez-Cortez +14 more
doaj +1 more source
Scientific Reports, 2021 Chromatin configuration influences gene expression in eukaryotes at multiple levels, from individual nucleosomes to chromatin domains several Mb long.
John A. Halsall +6 more
doaj +1 more source
Frontiers in Immunology, 2020 Associations between blood cancer and genetic predisposition, including both inherited variants and acquired mutations and epimutations, have been well characterized.
Llorenç Rovirosa +3 more
doaj +1 more source
Chromatin Alterations in Neurological Disorders and Strategies of (Epi)Genome Rescue
Pharmaceuticals, 2021 Neurological disorders (NDs) comprise a heterogeneous group of conditions that affect the function of the nervous system. Often incurable, NDs have profound and detrimental consequences on the affected individuals’ lives.
Marcin Janowski +3 more
doaj +1 more source
WormBook, 2006 The DNA in eukaryotes is wrapped around a histone octamer core, together comprising the main subunit of chromatin, the nucleosome. Modifications of the nucleosomal histones in the genome correlate with the ability or inability of chromatin to form higher order structures, that in turn influence gene activity.
Christine E, Schaner, William G, Kelly
openaire +2 more sources
Internal modifications in the CENP-A nucleosome modulate centromeric dynamics
Epigenetics & Chromatin, 2017 Background Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 variant CENP-A, few modifications have
Minh Bui +7 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Modulation of the functional interfaces between retroviral intasomes and the human nucleosome
mBio, 2023 Infection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA wrapped around ...
E. Mauro +18 more
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source