Results 41 to 50 of about 392,110 (289)
Microbial Cell, 2023 Enhanced levels of acetic acid reduce the activity of yeast strains employed for industrial fermentation-based applications. Therefore, unraveling the genetic factors underlying the regulation of the tolerance and sensitivity of yeast towards acetic acid
Nitu Saha +2 more
doaj +1 more source
Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay. [PDF]
, 2016 Chromatin accessibility captures in vivo protein-chromosome binding status, and is considered an informative proxy for protein-DNA interactions. DNase I and Tn5 transposase assays require thousands to millions of fresh cells for comprehensive chromatin ...
Fung, Ho-Lim +6 more
core +2 more sources
Cell, 2010 Chromatin consists of DNA and a large number of associated proteins. Filion et al. (2010) provide a genome-wide analysis of the location of 53 chromatin proteins in Drosophila, revealing important principles underlying chromatin regulation and providing colorful insights into their organization.
openaire +3 more sources
Epigenetics & Chromatin, 2018 Background Linker histones establish and maintain higher-order chromatin structure. Eleven linker histone subtypes have been reported in mammals. HILS1 is a spermatid-specific linker histone, and its expression overlaps with the histone–protamine ...
Laxmi Narayan Mishra +6 more
doaj +1 more source
Crosstalk between chromatin structure, cohesin activity and transcription [PDF]
, 2019 Background: A complex interplay between chromatin and topological machineries is critical for genome architec‑ ture and function. However, little is known about these reciprocal interactions, even for cohesin, despite its multiple roles in DNA metabolism.
Andújar, Eloísa +8 more
core +1 more source
Scientific Reports, 2017 Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene
Virginia C. Rodríguez-Cortez +14 more
doaj +1 more source
Chromatin Alterations in Neurological Disorders and Strategies of (Epi)Genome Rescue
Pharmaceuticals, 2021 Neurological disorders (NDs) comprise a heterogeneous group of conditions that affect the function of the nervous system. Often incurable, NDs have profound and detrimental consequences on the affected individuals’ lives.
Marcin Janowski +3 more
doaj +1 more source
Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development. [PDF]
, 2018 During the phylotypic period, embryos from different genera show similar gene expression patterns, implying common regulatory mechanisms. Here we set out to identify enhancers involved in the initial events of cardiogenesis, which occurs during the ...
Bruneau, Benoit G +5 more
core +3 more sources
Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]
, 2017 Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Adams, Peter D. +23 more
core +2 more sources
Enhancement of homology-directed repair with chromatin donor templates in cells. [PDF]
, 2020 A key challenge in precise genome editing is the low efficiency of homology-directed repair (HDR). Here we describe a strategy for increasing the efficiency of HDR in cells by using a chromatin donor template instead of a naked DNA donor template.
Cruz-Becerra, Grisel, Kadonaga, James T
core +1 more source