Results 41 to 50 of about 971,786 (390)
Evaluation of genome-wide chromatin library of Stat5 binding sites in human breast cancer [PDF]
, 2005 BACKGROUND: There is considerable interest in identifying target genes and chromatin binding sites for transcription factors in a genome-wide manner. Such information may become useful in diagnosis and treatment of disease, drug target identification ...
LeBaron, Matthew J +2 more
core +3 more sources
Scientific Reports, 2017 Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene
Virginia C. Rodríguez-Cortez +14 more
doaj +1 more source
Chromatin Alterations in Neurological Disorders and Strategies of (Epi)Genome Rescue
Pharmaceuticals, 2021 Neurological disorders (NDs) comprise a heterogeneous group of conditions that affect the function of the nervous system. Often incurable, NDs have profound and detrimental consequences on the affected individuals’ lives.
Marcin Janowski +3 more
doaj +1 more source
Rapid, solid-phase based automated analysis of chromatin structure and transcription factor occupancy in living eukaryotic cells [PDF]
, 2005 Transcription factors, chromatin components and chromatin modification activities are involved in many diseases including cancer. However, the means by which alterations in these factors influence the epigenotype of specific cell types is poorly ...
Bonifer, C. +3 more
core +2 more sources
Distinct roles of haspin in stem cell division and male gametogenesis
Scientific Reports, 2021 The kinase haspin phosphorylates histone H3 at threonine-3 (H3T3ph) during mitosis. H3T3ph provides a docking site for the Chromosomal Passenger Complex at the centromere, enabling correction of erratic microtubule-chromosome contacts.
Katerina Soupsana +10 more
doaj +1 more source
Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts [PDF]
, 2001 Oncoprotein 18 (Op18) is a microtubule-destabilizing protein that is negatively regulated by phosphorylation. To evaluate the role of the three Op18 phosphorylation sites in Xenopus (Ser 16, 25, and 39), we added wild-type Op18, a nonphosphorylatable ...
Andersen +67 more
core +4 more sources
Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]
, 1996 In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M. +3 more
core +2 more sources
eLife, 2021 In eukaryotes, paused replication forks are prone to collapse, which leads to genomic instability, a hallmark of cancer. Dbf4-dependent kinase (DDK)/Hsk1Cdc7 is a conserved replication initiator kinase with conflicting roles in replication stress ...
Shalini Aricthota, Devyani Haldar
doaj +1 more source
The Texture of Chromatin [PDF]
Cell, 2019 DNA-replication machinery introduces intertwining and supercoiling of DNA strands as it traverses the double helix, which could impede replication and compromise genome stability. A new study in Cell shows that the intrinsic physical properties of chromatin fibers dictate how torsional stress is partitioned to minimize these risks and facilitate DNA ...
David Levens, Fedor Kouzine
openaire +3 more sources
Frontiers in Immunology, 2020 Associations between blood cancer and genetic predisposition, including both inherited variants and acquired mutations and epimutations, have been well characterized.
Llorenç Rovirosa +3 more
doaj +1 more source