Results 41 to 50 of about 781,130 (308)

Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

Epigenetics & Chromatin, 2017
Background Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 variant CENP-A, few modifications have
Minh Bui, Mary Pitman, Arthur Nuccio, Serene Roque, Paul Gregory Donlin-Asp, Aleksandra Nita-Lazar, Garegin A. Papoian, Yamini Dalal   +7 more
doaj   +1 more source

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization. [PDF]

, 2014
Vascular endothelial growth factor A (VEGF-A) is a master regulator of angiogenesis, vascular development and function. In this study we investigated the transcriptional regulation of VEGF-A-responsive genes in primary human aortic endothelial cells ...
Benner, Christopher, Glass, Christopher K, Heinz, Sven, Kaikkonen, Minna U, Kansanen, Emilia, Kivelä, Annukka M, Laitalainen, Jarkko, Niskanen, Henri, Romanoski, Casey E, Ylä-Herttuala, Seppo   +9 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Modulation of the functional interfaces between retroviral intasomes and the human nucleosome

mBio, 2023
Infection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA wrapped around ...
E. Mauro, D. Lapaillerie, C. Tumiotto, C. Charlier, F. Martins, S. F. Sousa, M. Métifiot, P. Weigel, K. Yamatsugu, M. Kanai, H. Munier-Lehmann, C. Richetta, M. Maisch, J. Dutrieux, J. Batisse, M. Ruff, O. Delelis, P. Lesbats, V. Parissi   +18 more
doaj   +1 more source

Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. [PDF]

, 2019
Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated.
Amaral, Maria Luisa, Chee, Sora, Chi, Neil C, Destici, Eugin, Evans, Sylvia M, Fang, Rongxin, Farah, Elie N, Grinstein, Jonathan D, Hu, Rong, Huang, Hui, Izpisua Belmonte, Juan Carlos, Lee, Ah Young, Li, Ting, Ma, Kaiyue, Preissl, Sebastian, Qiu, Yunjiang, Ren, Bing, Wu, Jun, Ye, Zhen, Yu, Leqian, Zhang, Yanxiao, Zhu, Quan   +21 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Tumorigenic Cell Reprogramming and Cancer Plasticity: Interplay between Signaling, Microenvironment, and Epigenetics

Stem Cells International, 2018
Accumulating evidences indicate that many tumors rely on subpopulations of cancer stem cells (CSCs) with the ability to propagate malignant clones indefinitely and to produce an overt cancer.
Vittoria Poli, Luca Fagnocchi, Alessio Zippo   +2 more
doaj   +1 more source

DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks

eLife, 2021
In eukaryotes, paused replication forks are prone to collapse, which leads to genomic instability, a hallmark of cancer. Dbf4-dependent kinase (DDK)/Hsk1Cdc7 is a conserved replication initiator kinase with conflicting roles in replication stress ...
Shalini Aricthota, Devyani Haldar
doaj   +1 more source

Chromatin: a tunable spring at work inside chromosomes

, 2001
This paper focuses on mechanical aspects of chromatin biological functioning. Within a basic geometric modeling of the chromatin assembly, we give for the first time the complete set of elastic constants (twist and bend persistence lengths, stretch ...
A. E. H. Love, A. Leforestier, A. S. Belmont, A. Wolffe, A. Worcel, Annick Lesne, B. Houchmandzadeh, C. Balbi, C. Baumann, C. Bouchiat, C. L. Woodcock, C. S. O’Hern, Eli Ben-Haïm, F. Livolant, G. Janninck, H. Schiessel, I. Russo, J. Bednar, J. Marko, J. Marko, J. Marko, J. O. Thomas, J. T. Finch, J. W. Phillips, J. Widom, J. Widom, J. Yao, J. Zlatanova, Jean-Marc Victor, K. Luger, K. van Holde, K. van Holde, K. van Holde, L. M. Carruthers, L. M. Carruthers, M. Poirier, O. Kratky, P. T. Lowary, R. D. Kamien, R. R. Netz, S. B. Smith, S. H. Leuba, S. H. Leuba, S. H. Leuba, S. Przybyl, T. Odijk, T. R. Strick, V. Katritch, W. Saenger, Y. Cui, Z. Kam   +50 more
core   +1 more source