Results 41 to 50 of about 834,176 (358)

The Structure of Chromatin [PDF]

Proceedings of the National Academy of Sciences, 1971
The DNA in chromatin of isolated thymus nuclei, and in two different preparations of deoxyribonucleoprotein extracted from chromatin, has been digested with DNase. By variation of the time of reaction and the concentration of enzyme, and by comparison of the action of the enzyme on (protein-free) DNA with its action on DNA complexed with protein in ...
openaire   +2 more sources

Nucleolus and chromatin [PDF]

Histochemistry and Cell Biology, 2018
The nucleolus as site of ribosome biogenesis holds a pivotal role in cell metabolism. It is composed of ribosomal DNA (rDNA), which is present as tandem arrays located in nucleolus organizer regions (NORs). In interphase cells, rDNA can be found inside and adjacent to nucleoli and the location is indicative for transcriptional activity of ribosomal ...
Christian Schöfer, Klara Weipoltshammer
openaire   +2 more sources

Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

Epigenetics & Chromatin, 2017
Background Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 variant CENP-A, few modifications have
Minh Bui, Mary Pitman, Arthur Nuccio, Serene Roque, Paul Gregory Donlin-Asp, Aleksandra Nita-Lazar, Garegin A. Papoian, Yamini Dalal   +7 more
doaj   +1 more source

DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks

eLife, 2021
In eukaryotes, paused replication forks are prone to collapse, which leads to genomic instability, a hallmark of cancer. Dbf4-dependent kinase (DDK)/Hsk1Cdc7 is a conserved replication initiator kinase with conflicting roles in replication stress ...
Shalini Aricthota, Devyani Haldar
doaj   +1 more source

Chromatin: a tunable spring at work inside chromosomes

, 2001
This paper focuses on mechanical aspects of chromatin biological functioning. Within a basic geometric modeling of the chromatin assembly, we give for the first time the complete set of elastic constants (twist and bend persistence lengths, stretch ...
A. E. H. Love, A. Leforestier, A. S. Belmont, A. Wolffe, A. Worcel, Annick Lesne, B. Houchmandzadeh, C. Balbi, C. Baumann, C. Bouchiat, C. L. Woodcock, C. S. O’Hern, Eli Ben-Haïm, F. Livolant, G. Janninck, H. Schiessel, I. Russo, J. Bednar, J. Marko, J. Marko, J. Marko, J. O. Thomas, J. T. Finch, J. W. Phillips, J. Widom, J. Widom, J. Yao, J. Zlatanova, Jean-Marc Victor, K. Luger, K. van Holde, K. van Holde, K. van Holde, L. M. Carruthers, L. M. Carruthers, M. Poirier, O. Kratky, P. T. Lowary, R. D. Kamien, R. R. Netz, S. B. Smith, S. H. Leuba, S. H. Leuba, S. H. Leuba, S. Przybyl, T. Odijk, T. R. Strick, V. Katritch, W. Saenger, Y. Cui, Z. Kam   +50 more
core   +1 more source

The Snf2 Homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme [PDF]

, 2010
The Saccharomyces cerevisiae Fun30 (Function unknown now 30) protein shares homology with an extended family of Snf2-related ATPases. Here we report the purification of Fun30 principally as a homodimer with a molecular mass of about 250 kDa.
Adra, Ahmed H. Hassan, Barton, Becker, Bruno, Cairns, Clark, Collins, Daniel Ryan, Dillingham, Ferreira, Ferreira, Flaus, Flaus, Gavin, Hartley, Hassan, Hassan, Kouzarides, Krogan, Lowary, Luger, Mizuguchi, Neves-Costa, Okazaki, Ouspenski, Papamichos-Chronakis, Philippe Prochasson, Puig, Racki, Salma Awad, Schoor, Schoor, Shih, Smith, Soininen, Stockdale, Strohner, Suter, Thåström, Tom Owen-Hughes, Ubersax, Whitehouse, Zofall   +43 more
core   +4 more sources

Chromatin Hydrodynamics [PDF]

Biophysical Journal, 2014
Following recent observations of large scale correlated motion of chromatin inside the nuclei of live differentiated cells, we present a hydrodynamic theory-the two-fluid model-in which the content of a nucleus is described as a chromatin solution with the nucleoplasm playing the role of the solvent and the chromatin fiber that of a solute. This system
Bruinsma, Robijn, Grosberg, Alexander Y, Rabin, Yitzhak, Zidovska, Alexandra   +3 more
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Modulation of the functional interfaces between retroviral intasomes and the human nucleosome

mBio, 2023
Infection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA wrapped around ...
E. Mauro, D. Lapaillerie, C. Tumiotto, C. Charlier, F. Martins, S. F. Sousa, M. Métifiot, P. Weigel, K. Yamatsugu, M. Kanai, H. Munier-Lehmann, C. Richetta, M. Maisch, J. Dutrieux, J. Batisse, M. Ruff, O. Delelis, P. Lesbats, V. Parissi   +18 more
doaj   +1 more source

Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. [PDF]

, 2019
Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated.
Amaral, Maria Luisa, Chee, Sora, Chi, Neil C, Destici, Eugin, Evans, Sylvia M, Fang, Rongxin, Farah, Elie N, Grinstein, Jonathan D, Hu, Rong, Huang, Hui, Izpisua Belmonte, Juan Carlos, Lee, Ah Young, Li, Ting, Ma, Kaiyue, Preissl, Sebastian, Qiu, Yunjiang, Ren, Bing, Wu, Jun, Ye, Zhen, Yu, Leqian, Zhang, Yanxiao, Zhu, Quan   +21 more
core   +2 more sources