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Increased chromatin accessibility underpins senescence
The FEBS JournalSenescence is a cellular state induced by various stressors or extracellular signals, but a universal pathway that triggers this process irrespective of the initial stressor has yet to be identified. Recent data indicate that chromatin opening, particularly in the noncoding genome, is a hallmark of cellular senescence.
Stéphane Lopes‐Paciencia +1 more
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Single-molecule chromatin accessibility
2021This project is based on methyltransferase to conduct a single molecule chromosome accessibility study.
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Cancer chromatin accessibility landscape
Science, 2018Cancer The Cancer Genome Atlas (TCGA) provides a high-quality resource of molecular data on a large variety of human cancers. Corces et al. used a recently modified assay to profile chromatin accessibility to determine the accessible chromatin landscape in 410 TCGA samples from 23 cancer types (see the Perspective by Taipale).
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A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility
Cell, 2022Shu-Hsien Sheu, David E Clapham
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A single-cell atlas of chromatin accessibility in the human genome
Cell, 2021Kai Zhang +2 more
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Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages
Cell Reports, 2022Toshifumi Azuma +2 more
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DNA methylation-linked chromatin accessibility affects genomic architecture in Arabidopsis
Proceedings of the National Academy of Sciences of the United States of America, 2021Zhenhui Zhong +2 more
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