Results 1 to 10 of about 17,945 (147)
Epigenetics and Chromatin: Interactions and processes Boston, MA, USA. 11-13 March 2013. Abstracts. [PDF]
Epigenetics Chromatin, 2013 The Eukaryotic genome is packaged together with histone proteins to form the nucleoprotein structure called chromatin. This packaging of DNA into chromatin is critical to prevent inappropriate access to the DNA in order to enable the fundamental processes of the genome, such as gene expression, DNA repair and DNA replication, to be highly regulated ...
Jessica K. Tyler
europepmc +4 more sources
Replication-Coupled Chromatin Remodeling: An Overview of Disassembly and Assembly of Chromatin during Replication [PDF]
International Journal of Molecular Sciences, 2021 The doubling of genomic DNA during the S-phase of the cell cycle involves the global remodeling of chromatin at replication forks. The present review focuses on the eviction of nucleosomes in front of the replication forks to facilitate the passage of replication machinery and the mechanism of replication-coupled chromatin assembly behind the ...
Céline Duc, Christophe Thiriet
openaire +5 more sources
Chromatin gels are auxetic due to cooperative nucleosome assembly and disassembly dynamics
EPL (Europhysics Letters), 2017 We study "chromatin gels", model systems for chromatin, to theoretically predict the conditions, under which such gels show negative Poisson's ratios. A chromatin gel shows phase separation due to an instability arising from the disassembly of nucleosomes by RNA polymerases during transcription.
Yamamoto, T., Schiessel, H.
openaire +5 more sources
Chromatin Assembly and Disassembly
The FASEB Journal, 2013 The eukaryotic genome is packaged together with histone proteins to form the nucleoprotein structure called chromatin. This packaging of DNA into chromatin is critical to prevent inappropriate access to the DNA in order to enable the fundamental processes of the genome, such as gene expression, DNA repair and DNA replication, to be highly regulated ...
Jessica K. Tyler
openaire +2 more sources
PLoS Biology, 2014 At blocked replication forks, homologous recombination mediates the nascent strands to switch template in order to ensure replication restart, but faulty template switches underlie genome rearrangements in cancer cells and genomic disorders ...
Violena Pietrobon +6 more
doaj +3 more sources
Chromatin Assembly and Disassembly During Genomic Processes
The FASEB Journal, 2008 Chromatin assembly and disassembly has long been acknowledged to accompany the process of DNA replication. Accordingly, we previously discovered a key histone chaperone involved in the assembly of chromatin during DNA replication, termed Asf1 (Tyler et al., Nature 1999).
Jessica K Tyler +3 more
openaire +2 more sources
USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination [PDF]
Nature CommunicationsThe CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability.
Derek L. Bolhuis +7 more
doaj +2 more sources
PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback [PDF]
Nature CommunicationsCircadian rhythms in gene expression are coincident with 24 hr dynamics in the recruitment of the core-clock transcription factor heterodimer CLOCK-BMAL1 to chromatin.
Dominika Letkova +5 more
doaj +2 more sources
Nucleosome assembly and disassembly pathways in vitro.
PLoS ONE, 2022 Structural fluctuations of nucleosomes modulate the access to internal DNA in eukaryotic cells; clearly characterisation of this fundamental process is crucial to understanding gene regulation.
Akiko Hatakeyama +6 more
doaj +2 more sources
Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes [PDF]
Diabetes & Metabolism Journal, 2023 Background Dysfunction of vascular endothelial cells (ECs) plays a central role in the pathogenesis of cardiovascular complications in diabetes. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) is a ...
Ju Wang +4 more
doaj +1 more source