Malaria Journal, 2010 Background Nucleosome assembly proteins (NAPs) are histone chaperones that are crucial for the shuttling and incorporation of histones into nucleosomes.
Maier Alexander G +8 more
doaj +1 more source
Genes to Cells, Volume 30, Issue 3, May 2025.JMJD1A‐mediated H3K9me2 demethylation is primarily confined to A compartments on a megabase scale during adipogenesis. Genome‐wide H3K9me2 analysis on a kilobase scale demonstrated that JMJD1A iron‐dependently targets genes involved in PPAR signaling and lipid metabolism.
Shinnosuke Masuda +7 more
wiley +1 more source
Combinatorial omics analysis reveals perturbed lysosomal homeostasis in collagen VII-deficient keratinocytes [PDF]
, 2018 The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 lead to the skin disorder dystrophic epidermolysis bullosa (DEB), are ...
Athanasiou, Ioannis +13 more
core +1 more source
GCN5‐related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato
New Phytologist, Volume 246, Issue 3, Page 1217-1235, May 2025.Summary The functions of histone acetyltransferases (HATs) in the genetic control of crop traits and the underlying mechanisms are poorly understood. We studied the function of tomato HOOKLESS2 (SlHLS2), a member of the GCN5 family of HATs, through genetic, molecular and genomic approaches. Tomato hls2 mutants generated through CRISPR‐cas9 gene editing
Namrata Jaiswal +3 more
wiley +1 more source
Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner [PDF]
, 2007 Impaired gap filling and sealing of chromosomal DNA in nucleotide excision repair (NER) leads to genome instability. XRCC1-DNA ligase IIIa (XRCC1-Lig3) plays a central role in the repair of DNA single-strand breaks but has never been implicated in NER ...
Aboussekhra +57 more
core +1 more source
The Structural Basis of Gene Regulation for DNA Organized as Chromatin
CHIMIA, 2001 DNA in the nucleus of eukaryotic cells is organized in chromatin, a nucleoprotein complex containing roughly half DNA and half protein. The nucleosome is the underlying DNA packaging element in chromatin, repeating approximately every 200 base ...
Timothy J. Richmond
doaj
Kinesins relocalize the chromosomal passenger complex to the midzone for spindle disassembly. [PDF]
, 2018 Mitotic spindle disassembly after chromosome separation is as important as spindle assembly, yet the molecular mechanisms for spindle disassembly are unclear.
Avunie-Masala +43 more
core +1 more source
Structural visualization of key steps in nucleosome reorganization by human FACT
Scientific Reports, 2019 Facilitates chromatin transcription (FACT) is a histone chaperone, which accomplishes both nucleosome assembly and disassembly. Our combined cryo-electron microscopy (EM) and native mass spectrometry (MS) studies revealed novel key steps of nucleosome ...
Kouta Mayanagi +7 more
doaj +1 more source
NAP1 Family Histone Chaperones Are Required for Somatic Homologous Recombination in Arabidopsis [PDF]
, 2012 Homologous recombination (HR) is essential for maintaining genome integrity and variability. To orchestrate HR in the context of chromatin is a challenge, both in terms of DNA accessibility and restoration of chromatin organization after DNA repair ...
Aiwu Dong +5 more
core +2 more sources
CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state [PDF]
, 2013 Accurate chromosome segregation requires assembly of the multiprotein kinetochore complex. Prior work has identified more than 100 different kinetochore components in human cells. However, little is known about the regulatory processes that specify their
Carroll +26 more
core +2 more sources