Results 121 to 130 of about 19,014 (210)
An investigation of emerin and nuclear lamins: : Interactions, distribution, and role in cell cycle regulation, in cells derived from EDMD patients. [PDF]
, 2002 Emery Dreifuss muscular dystrophy (EDMD) is caused by mutations either in the gene encoding emerin or in the gene encoding A-type lamins (lamins A and C).
Maria, Choleza
core
Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies
MedComm, Volume 7, Issue 6, June 2026.Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge +9 more
wiley +1 more source
Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 2, June 2026.Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang +7 more
wiley +1 more source
Epigenetics & Chromatin, 2012 Background The protein anti-silencing function 1 (Asf1) chaperones histones H3/H4 for assembly into nucleosomes every cell cycle as well as during DNA transcription and repair.
Chavez Myrriah S +5 more
doaj +1 more source
Structural insights into chromatin assembly factor 1 and nucleosome assembly mechanism [PDF]
, 2018 2018 Spring.Includes bibliographical references.The eukaryotic genome is highly packed with histones to form chromatin. The basic building unit of chromatin is the nucleosome, which consists of a histone octamer core, wrapped by 147 base pairs of DNA ...
Bailey, Susan, committee member +4 more
core
Molecular Insights Into Heat Stress Resilience in Chickpea Near‐Isogenic Lines
Plant, Cell &Environment, Volume 49, Issue 7, Page 4577-4580, July 2026.
Miriam Negussu +7 more
wiley +1 more source
Protein Science, Volume 35, Issue 6, June 2026.Abstract Alzheimer's disease (AD) is characterized by the intracellular aggregation of the microtubule‐associated protein Tau. While the presence of large, insoluble neurofibrillary tangles has long been the primary focus of this research, a paradigm shift in the field now highlights smaller, soluble oligomers as the more neurotoxic Tau species leading
Joshua T. Skrehot, Dmitry Kurouski
wiley +1 more source
Does chromatin remodeling mark systemic acquired resistance?
, 2009 The recognition of plant pathogens activates local defense responses and triggers a long-lasting systemic acquired resistance (SAR) response. Activation of SAR requires the hormone salicylic acid (SA), which induces SA-responsive gene expression.
van den Burg, H.A. +3 more
core +1 more source
The FEBS Journal, Volume 293, Issue 12, Page 3588-3600, June 2026.Polyphosphate interaction with Hfq and RNA drives phase separation and amyloid self‐assembly, uncovering a previously unrecognized role for polyP in bacterial stress responses. Our findings reveal new insights into the molecular mechanisms of RNA‐mediated phase separation, highlighting the role of polyP as a key modulator of this process. Polyphosphate
Kevin Mosca +5 more
wiley +1 more source
Post‐transcriptional regulatory networks: The dynamic interplay of RNA‐binding proteins
The FEBS Journal, Volume 293, Issue 12, Page 3423-3441, June 2026.Post‐transcriptional gene expression regulation is controlled by RNA‐binding proteins (RBPs), which influence many processes including splicing, localization, translation, and decay. Rather than acting alone, RBPs bind RNAs combinatorially, forming complex, context‐dependent regulatory networks.
Lena A. Street +2 more
wiley +1 more source