Results 11 to 20 of about 28,191 (215)

Nucleosome Assembly and Disassembly in vitro Are Governed by Chemical Kinetic Principles

Frontiers in Cell and Developmental Biology, 2021
As the elementary unit of eukaryotic chromatin, nucleosomes in vivo are highly dynamic in many biological processes, such as DNA replication, repair, recombination, or transcription, to allow the necessary factors to gain access to their substrate.
Hongyu Zhao, Hongyu Zhao, Mingxin Guo, Mingxin Guo, Fenghui Zhang, Fenghui Zhang, Xueqin Shao, Xueqin Shao, Guoqing Liu, Guoqing Liu, Yongqiang Xing, Yongqiang Xing, Xiujuan Zhao, Xiujuan Zhao, Liaofu Luo, Liaofu Luo, Lu Cai, Lu Cai   +17 more
doaj   +2 more sources

Structural comparisons reveal diverse binding modes between nucleosome assembly proteins and histones

Epigenetics & Chromatin, 2022
Nucleosome assembly proteins (NAPs) are histone chaperones that play a central role in facilitating chromatin assembly/disassembly which is of fundamental importance for DNA replication, gene expression regulation, and progression through the cell cycle.
Jasmita Gill, Anuj Kumar, Amit Sharma
doaj   +2 more sources

The histone chaperone Nrp1 is required for chromatin stability and nuclear division in Tetrahymena thermophila

Epigenetics & Chromatin, 2021
Histone chaperones facilitate DNA replication and repair by promoting chromatin assembly, disassembly and histone exchange. Following histones synthesis and nucleosome assembly, the histones undergo posttranslational modification by different enzymes and
Yinjie Lian, Huijuan Hao, Jing Xu, Tao Bo, Aihua Liang, Wei Wang   +5 more
doaj   +3 more sources

Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly

eLife, 2016
The cell achieves DNA double-strand break (DSB) repair in the context of chromatin structure. However, the mechanisms used to expose DSBs to the repair machinery and to restore the chromatin organization after repair remain elusive.
Xuan Li, Jessica K Tyler
doaj   +2 more sources

Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy

Frontiers in Molecular Biosciences, 2018
Cullin-RING (Really Interesting New Gene) E3 ubiquitin ligases (CRLs), the largest family of E3 ubiquitin ligases, are functional multi-subunit complexes including substrate receptors, adaptors, cullin scaffolds, and RING-box proteins.
Sang-Min Jang, Christophe E. Redon, Mirit I. Aladjem   +2 more
doaj   +2 more sources

How the cell cycle impacts chromatin architecture and influences cell fate

Frontiers in Genetics, 2015
Since the earliest observations of cells undergoing mitosis, it has been clear that there is an intimate relationship between the cell cycle and nuclear chromatin architecture.
Yiqin eMa, Kiriaki eKanakousaki, Laura eButtitta   +2 more
doaj   +2 more sources

RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases

eLife, 2017
For transcription through chromatin, RNA polymerase (Pol) II associates with elongation factors (EFs). Here we show that many EFs crosslink to RNA emerging from transcribing Pol II in the yeast Saccharomyces cerevisiae.
Sofia Battaglia, Michael Lidschreiber, Carlo Baejen, Phillipp Torkler, Seychelle M Vos, Patrick Cramer   +5 more
doaj   +2 more sources

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination. [PDF]

Nat Commun
The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability.
Bolhuis DL, Fleifel D, Bonacci T, Wang X, Mouery BL, Cook JG, Brown NG, Emanuele MJ.   +7 more
europepmc   +2 more sources

Nucleosome assembly and disassembly pathways in vitro.

PLoS ONE, 2022
Structural fluctuations of nucleosomes modulate the access to internal DNA in eukaryotic cells; clearly characterisation of this fundamental process is crucial to understanding gene regulation.
Akiko Hatakeyama, Yuliia Shymko, Brigitte Hartmann, Romain Retureau, Claude Nogues, Marco Pasi, Malcolm Buckle   +6 more
doaj   +2 more sources

Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes [PDF]

Diabetes & Metabolism Journal, 2023
Background Dysfunction of vascular endothelial cells (ECs) plays a central role in the pathogenesis of cardiovascular complications in diabetes. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) is a ...
Ju Wang, Hui Zhou, Jinhua Shao, Shu Zhang, Jing Jin   +4 more
doaj   +1 more source