Results 11 to 20 of about 17,945 (147)
Nucleosome Assembly and Disassembly in vitro Are Governed by Chemical Kinetic Principles
Frontiers in Cell and Developmental Biology, 2021 As the elementary unit of eukaryotic chromatin, nucleosomes in vivo are highly dynamic in many biological processes, such as DNA replication, repair, recombination, or transcription, to allow the necessary factors to gain access to their substrate.
Hongyu Zhao +17 more
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Effective dynamics of nucleosome configurations at the yeast PHO5 promoter
eLife, 2021 Chromatin dynamics are mediated by remodeling enzymes and play crucial roles in gene regulation, as established in a paradigmatic model, the Saccharomyces cerevisiae PHO5 promoter. However, effective nucleosome dynamics, that is, trajectories of promoter
Michael Roland Wolff +3 more
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Nucleosome proteostasis and histone turnover
Frontiers in Molecular Biosciences, 2022 Maintenance of protein folding homeostasis, or proteostasis is critical for cell survival as well as for execution of cell type specific biological processes such as muscle cell contractility, neuronal synapse and memory formation, and cell transition ...
Adrian Arrieta +3 more
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Epigenetics & Chromatin, 2022 Nucleosome assembly proteins (NAPs) are histone chaperones that play a central role in facilitating chromatin assembly/disassembly which is of fundamental importance for DNA replication, gene expression regulation, and progression through the cell cycle.
Jasmita Gill, Anuj Kumar, Amit Sharma
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
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Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus
FEBS Open Bio, 2021 Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually just regarded as an apoptotic trigger.
Katiuska González‐Arzola +7 more
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FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1. [PDF]
PLoS Genetics, 2010 The FACT complex participates in chromatin assembly and disassembly during transcription elongation. The yeast mutants affected in the SPT16 gene, which encodes one of the FACT subunits, alter the expression of G1 cyclins and exhibit defects in the G1/S ...
Macarena Morillo-Huesca +9 more
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A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans. [PDF]
PLoS Genetics, 2012 Unlike most eukaryotes, a kinetochore is fully assembled early in the cell cycle in budding yeasts Saccharomyces cerevisiae and Candida albicans. These kinetochores are clustered together throughout the cell cycle.
Jitendra Thakur, Kaustuv Sanyal
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Quantitative analysis of the transcription control mechanism
Molecular Systems Biology, 2010 Gene transcription requires a sequence of promoter state transitions, including chromatin remodeling, assembly of the transcription machinery, and clearance of the promoter by RNA polymerase.
Changhui Mao +6 more
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eLife, 2016 The cell achieves DNA double-strand break (DSB) repair in the context of chromatin structure. However, the mechanisms used to expose DSBs to the repair machinery and to restore the chromatin organization after repair remain elusive.
Xuan Li, Jessica K Tyler
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