Results 21 to 30 of about 28,191 (215)

Effective dynamics of nucleosome configurations at the yeast PHO5 promoter

eLife, 2021
Chromatin dynamics are mediated by remodeling enzymes and play crucial roles in gene regulation, as established in a paradigmatic model, the Saccharomyces cerevisiae PHO5 promoter. However, effective nucleosome dynamics, that is, trajectories of promoter
Michael Roland Wolff, Andrea Schmid, Philipp Korber, Ulrich Gerland   +3 more
doaj   +1 more source

Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability

Nature Cell Biology, 2023
Chromatin is dynamically reorganized when DNA replication forks are challenged. However, the process of epigenetic reorganization and its implication for fork stability is poorly understood.
Vincent Gaggioli, Calvin Lo, Nazaret Reverón-Gómez, Zuzana Jasencakova, Heura Domenech, Hong Nguyen, Simone Sidoli, A. Tvardovskiy, Sidrit Uruci, J. Slotman, Yi Chai, J. G. S. C. S. Gonçalves, E. Manolika, O. N. Jensen, David Wheeler, Sriram Sridharan, Sanjiban Chakrabarty, J. Demmers, R. Kanaar, Anja Groth, Nitika Taneja   +20 more
semanticscholar   +1 more source

H2A mono-ubiquitination differentiates FACT’s functions in nucleosome assembly and disassembly

Nucleic Acids Research, 2021
The histone chaperone FACT (FAcilitates Chromatin Transcription) plays an essential role in transcription and DNA replication by its dual functions on nucleosome assembly to maintain chromatin integrity and nucleosome disassembly to destabilize ...
Yi-Zhou Wang, Cuifang Liu, Jicheng Zhao, Juan Yu, Anfeng Luo, Xue Xiao, Shuoxing Dou, Lu Ma, Peng-Ye Wang, Ming Li, Guohong Li, Jianbin Yan, Ping-Yen Chen, Wei Li   +13 more
semanticscholar   +1 more source

Nucleosome proteostasis and histone turnover

Frontiers in Molecular Biosciences, 2022
Maintenance of protein folding homeostasis, or proteostasis is critical for cell survival as well as for execution of cell type specific biological processes such as muscle cell contractility, neuronal synapse and memory formation, and cell transition ...
Adrian Arrieta, Thomas M. Vondriska, Thomas M. Vondriska, Thomas M. Vondriska   +3 more
doaj   +1 more source

The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis

Nature Communications, 2022
The assembly of mammalian SWI/SNF chromatin remodeling complexes is developmentally programed, and loss/mutations of SWI/SNF subunits alter the levels of other components through proteolysis, causing cancers.
Pengfei Guo, Nam Hoang, Joseph Sanchez, Elaine Zhang, Keshari Rajawasam, Kristiana Trinidad, Hong Sun, Hui Zhang   +7 more
semanticscholar   +1 more source

Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus

FEBS Open Bio, 2021
Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually just regarded as an apoptotic trigger.
Katiuska González‐Arzola, Alejandra Guerra‐Castellano, Francisco Rivero‐Rodríguez, Miguel Á. Casado‐Combreras, Gonzalo Pérez‐Mejías, Antonio Díaz‐Quintana, Irene Díaz‐Moreno, Miguel A. De la Rosa   +7 more
doaj   +1 more source

ATP-dependent chromatosome remodeling [PDF]

, 2008
Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Dimitrov S., Langst G., Loyola A., Ner S.S., Shogren-Knaak M., Varga-Weisz P.D., Wisniewski J.R.   +6 more
core   +1 more source

FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1. [PDF]

PLoS Genetics, 2010
The FACT complex participates in chromatin assembly and disassembly during transcription elongation. The yeast mutants affected in the SPT16 gene, which encodes one of the FACT subunits, alter the expression of G1 cyclins and exhibit defects in the G1/S ...
Macarena Morillo-Huesca, Douglas Maya, Mari Cruz Muñoz-Centeno, Rakesh Kumar Singh, Vincent Oreal, Gajjalaiahvari Ugander Reddy, Dun Liang, Vincent Géli, Akash Gunjan, Sebastián Chávez   +9 more
doaj   +1 more source

The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation [PDF]

, 2011
Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant ...
Bowman, A., El-Mkami, Hassane, Norman, David George, Owen-Hughes, Tom, Singh, Vijender, Ward, Richard, Wiechens, Nicola   +6 more
core   +4 more sources

Nucleosome wrapping states encode principles of 3D genome organization. [PDF]

Nat Commun
Nucleosome is the basic structural unit of the genome. During processes like DNA replication and gene transcription, the conformation of nucleosomes undergoes dynamic changes, including DNA unwrapping and rewrapping, as well as histone disassembly and ...
Wen Z, Fang R, Zhang R, Yu X, Zhou F, Long H.   +5 more
europepmc   +2 more sources