Results 21 to 30 of about 17,945 (147)
Histone deposition promotes recombination-dependent replication at arrested forks.
PLoS Genetics, 2019 Replication stress poses a serious threat to genome stability. Recombination-Dependent-Replication (RDR) promotes DNA synthesis resumption from arrested forks.
Julien Hardy +9 more
doaj +1 more source
Membraneless organelles: a smart design for metabolic control
FEBS Open Bio, 2021 While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in the cell by avoiding the mixture of their components with the surroundings.
Irene Díaz‐Moreno +1 more
doaj +1 more source
How the cell cycle impacts chromatin architecture and influences cell fate
Frontiers in Genetics, 2015 Since the earliest observations of cells undergoing mitosis, it has been clear that there is an intimate relationship between the cell cycle and nuclear chromatin architecture.
Yiqin eMa +2 more
doaj +1 more source
Regulation of lamin properties and functions: does phosphorylation do it all? [PDF]
Open Biology, 2015 The main functions of lamins are their mechanical and structural roles as major building blocks of the karyoskeleton. They are also involved in chromatin structure regulation, gene expression, intracellular signalling pathway modulation and development ...
Magdalena Machowska +2 more
doaj +1 more source
Open Biology, 2022 Lamin A phosphorylation/de-phosphorylation is an important process during cells division as it allows for nuclear envelope (NE) disassembly at mitotic entry and its re-assembly during mitotic exit.
Florentin Huguet +4 more
doaj +1 more source
Dynamic Changes in Occupancy of Histone Variant H2A.Z during Induced Somatic Cell Reprogramming
Stem Cells International, 2016 The development of induced pluripotent stem cells (iPSCs) has enabled study of the mechanisms underlying cellular reprogramming. Here, we have studied the dynamic distribution of H2A.Z during induced reprogramming with chromatin immunoprecipitation deep ...
Fulu Dong +9 more
doaj +1 more source
Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. [PDF]
PLoS Genetics, 2007 To investigate the DNA damage response, we undertook a genome-wide study in Saccharomyces cerevisiae and identified 86 gene deletions that lead to increased levels of spontaneous Rad52 foci in proliferating diploid cells.
David Alvaro +2 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2018 Cullin-RING (Really Interesting New Gene) E3 ubiquitin ligases (CRLs), the largest family of E3 ubiquitin ligases, are functional multi-subunit complexes including substrate receptors, adaptors, cullin scaffolds, and RING-box proteins.
Sang-Min Jang +2 more
doaj +1 more source
Chromatin remodeling pathways in smooth muscle cell differentiation, and evidence for an integral role for p300. [PDF]
PLoS ONE, 2010 Phenotypic alteration of vascular smooth muscle cells (SMC) in response to injury or inflammation is an essential component of vascular disease. Evidence suggests that this process is dependent on epigenetic regulatory processes.
Joshua M Spin +2 more
doaj +1 more source
Mechanism of curaxin-dependent nucleosome unfolding by FACT
Frontiers in Molecular Biosciences, 2022 Human FACT (FACT) is a multifunctional histone chaperone involved in transcription, replication and DNA repair. Curaxins are anticancer compounds that induce FACT-dependent nucleosome unfolding and trapping of FACT in the chromatin of cancer cells (c ...
Olesya I. Volokh +14 more
doaj +1 more source