Results 31 to 40 of about 17,945 (147)
Epigenetics & Chromatin, 2021 Histone chaperones facilitate DNA replication and repair by promoting chromatin assembly, disassembly and histone exchange. Following histones synthesis and nucleosome assembly, the histones undergo posttranslational modification by different enzymes and
Yinjie Lian +5 more
doaj +1 more source
Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast. [PDF]
PLoS ONE, 2012 The histone H3-H4 chaperone Asf1 is involved in chromatin assembly (or disassembly), histone exchange, regulation of transcription, and chromatin silencing in several organisms. To investigate the essential functions of Asf1 in Schizosaccharomyces pombe,
Katsuhiro Tanae +4 more
doaj +1 more source
Epigenetically Mediated Ciliogenesis and Cell Cycle Regulation, and Their Translational Potential
Cells, 2021 Primary cilia biogenesis has been closely associated with cell cycle progression. Cilia assemble when cells exit the cell cycle and enter a quiescent stage at the post-mitosis phase, and disassemble before cells re-enter a new cell cycle.
Linda Xiaoyan Li, Xiaogang Li
doaj +1 more source
RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases
eLife, 2017 For transcription through chromatin, RNA polymerase (Pol) II associates with elongation factors (EFs). Here we show that many EFs crosslink to RNA emerging from transcribing Pol II in the yeast Saccharomyces cerevisiae.
Sofia Battaglia +5 more
doaj +1 more source
DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast. [PDF]
PLoS Genetics, 2013 Centromeres are specialized chromatin regions marked by the presence of nucleosomes containing the centromere-specific histone H3 variant CENP-A, which is essential for chromosome segregation.
Ulrika Norman-Axelsson +3 more
doaj +1 more source
Advanced Science, EarlyView.Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen +8 more
wiley +1 more source
Advanced Science, EarlyView.Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi +10 more
wiley +1 more source
Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenation
eLife, 2017 Mitotic chromosome assembly remains a big mystery in biology. Condensin complexes are pivotal for chromosome architecture yet how they shape mitotic chromatin remains unknown.
Ewa Piskadlo +2 more
doaj +1 more source
The Modular Circuitry of Apicomplexan Cell Division Plasticity
Frontiers in Cellular and Infection Microbiology, 2021 The close-knit group of apicomplexan parasites displays a wide variety of cell division modes, which differ between parasites as well as between different life stages within a single parasite species. The beginning and endpoint of the asexual replication
Marc-Jan Gubbels +4 more
doaj +1 more source
Advanced Science, EarlyView.A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra +23 more
wiley +1 more source