Epigenetically Mediated Ciliogenesis and Cell Cycle Regulation, and Their Translational Potential
Cells, 2021 Primary cilia biogenesis has been closely associated with cell cycle progression. Cilia assemble when cells exit the cell cycle and enter a quiescent stage at the post-mitosis phase, and disassemble before cells re-enter a new cell cycle.
Linda Xiaoyan Li, Xiaogang Li
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A Systemic Receptor Network Triggered by Human cytomegalovirus Entry [PDF]
, 2010 Virus entry is a multistep process that triggers a variety of cellular pathways interconnecting into a complex network, yet the molecular complexity of this network remains largely unsolved.
Li, Hong, Ren, Li, Wang, Anyou
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DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast. [PDF]
PLoS Genetics, 2013 Centromeres are specialized chromatin regions marked by the presence of nucleosomes containing the centromere-specific histone H3 variant CENP-A, which is essential for chromosome segregation.
Ulrika Norman-Axelsson +3 more
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CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis [PDF]
, 2017 Replisome disassembly is the final step of DNA replication in eukaryotes, involving the ubiquitylation and CDC48-dependent dissolution of the CMG helicase (CDC45-MCM-GINS).
A Franz +59 more
core +2 more sources
Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenation
eLife, 2017 Mitotic chromosome assembly remains a big mystery in biology. Condensin complexes are pivotal for chromosome architecture yet how they shape mitotic chromatin remains unknown.
Ewa Piskadlo +2 more
doaj +1 more source
The Modular Circuitry of Apicomplexan Cell Division Plasticity
Frontiers in Cellular and Infection Microbiology, 2021 The close-knit group of apicomplexan parasites displays a wide variety of cell division modes, which differ between parasites as well as between different life stages within a single parasite species. The beginning and endpoint of the asexual replication
Marc-Jan Gubbels +4 more
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Advanced Science, EarlyView.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +9 more
wiley +1 more source
Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication [PDF]
, 1994 The major residual structure that remains associated with the nuclear envelope following extraction of isolated nuclei or oocyte germinal vesicles with non-ionic detergents, nucleases and high salt is the lamina (Fawcett, 1966; Aaronson and Blobel ...
Bridger, JM +3 more
core
Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone. [PDF]
, 2019 We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface.
Brautigam, Chad A +9 more
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The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin
EMBO Journal, 2007 Heterochromatin normally has prescribed chromosomal positions and must not encroach on adjacent regions. We demonstrate that the fission yeast protein Epe1 stabilises silent chromatin, preventing the oscillation of heterochromatin domains.
S. Trewick +4 more
semanticscholar +1 more source