Results 61 to 70 of about 17,945 (147)

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, Volume 16, Issue 2, Page 268-278, February 2026.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, Volume 16, Issue 2, Page 382-396, February 2026.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

The Structural Basis of Gene Regulation for DNA Organized as Chromatin

CHIMIA, 2001
DNA in the nucleus of eukaryotic cells is organized in chromatin, a nucleoprotein complex containing roughly half DNA and half protein. The nucleosome is the underlying DNA packaging element in chromatin, repeating approximately every 200 base ...
Timothy J. Richmond
doaj  

Structure, localization and histone binding properties of nuclear-associated nucleosome assembly protein from Plasmodium falciparum

Malaria Journal, 2010
Background Nucleosome assembly proteins (NAPs) are histone chaperones that are crucial for the shuttling and incorporation of histones into nucleosomes.
Maier Alexander G, Brown Monica, Rug Melanie, Jain SK, Belrhali Hassan, Yogavel Manickam, Kumar Anuj, Gill Jasmita, Sharma Amit   +8 more
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Nuclear DNA of plastid origin (NUPTs), neglected driver of genome variation and evolutionary innovation

The Plant Journal, Volume 125, Issue 3, February 2026.
Significance Statement Contrary to expectation, NUPTs do not necessarily have a deleterious or ultimately neutral impact, nor are they necessarily purged from the genome. Instead, they can proliferate and eventually become fixed, generating new and novel genes, gene regions and regulatory elements, thereby significantly contributing to plant nuclear ...
Lorenzo Carretero‐Paulet, Juan Pablo Marczuk‐Rojas, Aaron Gálvez‐Salido   +2 more
wiley   +1 more source

Structural visualization of key steps in nucleosome reorganization by human FACT

Scientific Reports, 2019
Facilitates chromatin transcription (FACT) is a histone chaperone, which accomplishes both nucleosome assembly and disassembly. Our combined cryo-electron microscopy (EM) and native mass spectrometry (MS) studies revealed novel key steps of nucleosome ...
Kouta Mayanagi, Kazumi Saikusa, Naoyuki Miyazaki, Satoko Akashi, Kenji Iwasaki, Yoshifumi Nishimura, Kosuke Morikawa, Yasuo Tsunaka   +7 more
doaj   +1 more source

Molecular Insights Into Heat Stress Resilience in Chickpea Near‐Isogenic Lines

Plant, Cell &Environment, EarlyView.
Miriam Negussu, Maria Ventimiglia, Chiara Vergata, Matteo Buti, David J. Bonfil, Dudy Bar‐Zvi, Michele Zaccai, Federico Martinelli   +7 more
wiley   +1 more source

Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells

Cell Division, 2006
In eukaryotic cells, replication of genomic DNA initiates from multiple replication origins distributed on multiple chromosomes. To ensure that each origin is activated precisely only once during each S phase, a system has evolved which features periodic
Fujita Masatoshi
doaj   +1 more source

Regulation of Chromatin Assembly/Disassembly by Rtt109p, a Histone H3 Lys56-specific Acetyltransferase, in Vivo [PDF]

, 2010
Geetha Durairaj, Priyasri Chaurasia, Shweta Lahudkar, Shivani Malik, Abhijit Shukla, Sukesh R. Bhaumik   +5 more
openalex   +1 more source