Results 71 to 80 of about 17,945 (147)

Histone Chaperone Jun Dimerization Protein 2 (JDP2): Role in Cellular Senescence and Aging

Kaohsiung Journal of Medical Sciences, 2010
Transcription factor Jun dimerization protein 2 (JDP2) binds directly to histones and DNA, and inhibits p300-mediated acetylation of core histones and reconstituted nucleosomes that contain JDP2-recognition DNA sequences.
Yu-Chang Huang, Shigeo Saito, Kazunari Kzaushige Yokoyama   +2 more
doaj   +1 more source

Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells

Oncogenesis
Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. The tumor is refractory to treatment with a 5-year survival rate of only 15–25%, necessitating the development of novel therapeutics,
Justin W. Magrath, Dane A. Flinchum, Alifiani B. Hartono, Shruthi Sanjitha Sampath, Tina M. O’Grady, Melody Baddoo, Liang Haoyang, Xiaojiang Xu, Erik K. Flemington, Sean B. Lee   +9 more
doaj   +1 more source

Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice

Scientific Reports
Transforming acidic acid coiled-coil protein 3 (TACC3) and cytoskeleton associated protein 5 (cKAP5; or colonic hepatic tumor overexpressed gene, chTOG) are vital for spindle assembly and stabilization initiated through TACC3 Aurora-A kinase interaction.
Calvin Simerly, Emily Robertson, Caleb Harrison, Sydney Ward, Charlize George, Jasmine Deleon, Carrie Hartnett, Gerald Schatten   +7 more
doaj   +1 more source

The conformational flexibility of the C-terminus of histone H4 promotes histone octamer and nucleosome stability and yeast viability

Epigenetics & Chromatin, 2012
Background The protein anti-silencing function 1 (Asf1) chaperones histones H3/H4 for assembly into nucleosomes every cell cycle as well as during DNA transcription and repair.
Chavez Myrriah S, Scorgie Jean K, Dennehey Briana K, Noone Seth, Tyler Jessica K, Churchill Mair EA   +5 more
doaj   +1 more source

Histone binding of ASF1 is required for fruiting body development but not for genome stability in the filamentous fungus Sordaria macrospora

mBio
The highly conserved eukaryotic histone chaperone ASF1 is involved in the assembly and disassembly of nucleosomes during transcription, DNA replication, and repair. It was the first chaperone discovered to be involved in all three of these processes. The
Jan Breuer, Tobias Busche, Jörn Kalinowski, Minou Nowrousian   +3 more
doaj   +1 more source

Chromatin gels are auxetic due to cooperative nucleosome assembly and disassembly dynamics

Chromatin gels are auxetic due to cooperative nucleosome assembly and disassembly dynamics
We study "chromatin gels", model systems for chromatin, to theoretically predict the conditions, under which such gels show negative Poisson's ratios. A chromatin gel shows phase separation due to an instability arising from the disassembly of nucleosomes by RNA polymerases during transcription.
openaire  

Mitotic dynamics of the nuclear lamina in the backstage of chromosome separation. [PDF]

Commun Biol
Picotto J, Bertrand P, Pennarun G.
europepmc   +1 more source

The Dynamics of the ESCRT Machinery in Open Mitosis from Physiology to Pathology. [PDF]

Cells
La Torre M, Cannistrà F, Burla R, Saggio I.   +3 more
europepmc   +1 more source

Condensatopathies as a mechanistic framework for disease and integrated theranostic intervention. [PDF]

Theranostics
Li X, Wang H, Yao J, Han B, Zhao X, Jiang Y, Chen H, Yang Y, Hou H, Wang L.   +9 more
europepmc   +1 more source

Parasite nucleosomes: Chromatin dynamics rewired. [PDF]

PLoS Pathog
Deák G, Wilson MD.
europepmc   +1 more source