Results 41 to 50 of about 200,002 (292)

Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes [PDF]

, 2013
Death domain–associated protein (Daxx) cooperates with X-linked α-thalassaemia retardation syndrome protein (ATRX), a putative member of the sucrose non-fermentable 2 family of ATP-dependent chromatin-remodelling proteins, acting as the core ATPase ...
Andreas Mund, Badens, Baker, Berk, Berube, Blanchette, Carolin Bürck, Chatterjee, Cheng, Chinnadurai, Cuchet-Lourenco, Dallaire, Dellaire, Dobner, Drane, Everett, Flint, Frisch, Gibbons, Glass, Goldberg, Goldberg, Gostissa, Graham, Groitl, Gunther, Hancock, Harlow, Hassan, Hollenbach, Ishov, Ishov, Jin, Kahyo, Kindsmuller, Kindsmuller, Kindsmüller, Ko, Komatsu, Kosulin, Lewis, Lewis, Li, Lukashchuk, Lukashchuk, Mandy Glass, Marton, Matsumoto, Maul, McFarlane, Michaelson, Mitsudomi, Mund, Nevels, Nevins, Nevins, Niforou, Okuwaki, Orazio, Parks, Pelka, Peter Groitl, Peter Wimmer, Placek, Querido, Roger D. Everett, Ross, Rubenwolf, Sabrina Schreiner, Salomoni, Sarah Kinkley, Sarnow, Schreiner, Schreiner, Schreiner, Shenk, Si, Song, Stracker, Takahashi, Tang, Thomas Dobner, Torii, Täuber, Täuber, Ullman, White, Williams, Wilson, Wong, Wong, Xu, Xue   +92 more
core   +1 more source

Chromatin immunoprecipitation: optimization, quantitative analysis and data normalization

Plant Methods, 2007
Background Chromatin remodeling, histone modifications and other chromatin-related processes play a crucial role in gene regulation. A very useful technique to study these processes is chromatin immunoprecipitation (ChIP).
Peterhansel Christoph, Horst Ina, Danker Tanja, Offermann Sascha, Haring Max, Stam Maike   +5 more
doaj   +1 more source

Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability [PDF]

, 2017
R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive regulatory roles but are also a source of genomic instability.
Aguilera López, Andrés, Bayona Feliu, Aleix, Luna Varo, Rosa María, Pérez Calero, Carmen, Salas Armenteros, Irene, Tumini, Emanuela   +5 more
core   +1 more source

From human monocytes to genome-wide binding sites--a protocol for small amounts of blood: monocyte isolation/ChIP-protocol/library amplification/genome wide computational data analysis. [PDF]

PLoS ONE, 2014
Chromatin immunoprecipitation in combination with a genome-wide analysis via high-throughput sequencing is the state of the art method to gain genome-wide representation of histone modification or transcription factor binding profiles. However, chromatin
Sebastian Weiterer, Florian Uhle, Sabin Bhuju, Michael Jarek, Markus A Weigand, Marek Bartkuhn   +5 more
doaj   +1 more source

ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic β-cells

Journal of Lipid Research, 2006
Pancreatic β-cell dysfunction is central to the pathogenesis of type 2 diabetes and may involve secretory failure through glucolipotoxity. The relative importance of the transcription factors carbohydrate-responsive element binding protein (ChREBP ...
Gabriela da Silva Xavier, Guy A. Rutter, Frédérique Diraison, Chrysovalantis Andreolas, Isabelle Leclerc   +4 more
doaj   +1 more source

Titration-based normalization of antibody amount improves consistency of ChIP-seq experiments

BMC Genomics, 2023
Chromatin immunoprecipitation (ChIP) is an antibody-based approach that is frequently utilized in chromatin biology and epigenetics. The challenge in experimental variability by unpredictable nature of usable input amounts from samples and undefined ...
Ariel Caride, Jin Sung Jang, Geng-Xian Shi, Sam Lenz, Jian Zhong, Kwan Hyun Kim, Mariet Allen, Keith D. Robertson, Gianrico Farrugia, Tamas Ordog, Nilüfer Ertekin-Taner, Jeong-Heon Lee   +11 more
doaj   +1 more source

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. [PDF]

, 2009
Life and death fate decisions allow cells to avoid massive apoptotic death in response to genotoxic stress. Although the regulatory mechanisms and signalling pathways controlling DNA repair and apoptosis are well characterized, the precise molecular ...
Cook, Peter J, Glass, Christopher K, Ju, Bong Gun, Rosenfeld, Michael G, Telese, Francesca, Wang, Xiangting   +5 more
core   +2 more sources

A Computational Model of Quantitative Chromatin Immunoprecipitation (ChIP) Analysis

Cancer Informatics, 2008
Chromatin immunoprecipitation (ChIP) analysis is widely used to identify the locations in genomes occupied by transcription factors (TFs). The approach involves chemical cross-linking of DNA with associated proteins, fragmentation of chromatin by ...
Stephen J. Brandt, Joel Soltman, Brett A. McKinney, Philip S. Crooke, Jingping Xie   +4 more
doaj   +2 more sources

MeCP2 interacts with chromosomal microRNAs in brain

Epigenetics, 2017
Although methyl CpG binding domain protein-2 (MeCP2) is commonly understood to function as a silencing factor at methylated DNA sequences, recent studies also show that MeCP2 can bind unmethylated sequences and coordinate gene activation.
Abdul Waheed Khan, Mark Ziemann, Haloom Rafehi, Scott Maxwell, Giuseppe D. Ciccotosto, Assam El-Osta   +5 more
doaj   +1 more source

Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1 [PDF]

, 2014
The Epstein-Barr virus (EBV) nuclear antigen 3 family of protein is critical for the EBV-induced primary B-cell growth transformation process. Using a yeast two-hybrid screen we identified 22 novel cellular partners of the EBNA3s. Most importantly, among
Bazot, Q, Deschamps, T, Gruffat, H, Harth-Hertle, ML, Kempkes, B, Leblanc, P, Lotteau, V, Manet, E, Rabourdin-Combe, C, Siouda, M, Tafforeau, L, Tommasino, M   +11 more
core   +6 more sources