Improving Chromatin-Interaction Prediction Using Single-Cell Open-Chromatin Profiles and Making Insight Into the Cis-Regulatory Landscape of the Human Brain [PDF]
Frontiers in Genetics, 2021 Single-cell open-chromatin profiles have the potential to reveal the pattern of chromatin-interaction in a cell type. However, currently available cis-regulatory network prediction methods using single-cell open-chromatin profiles focus more on local ...
Neetesh Pandey +3 more
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Hi-C Chromatin Interaction Networks Predict Co-expression in the Mouse Cortex. [PDF]
PLoS Computational Biology, 2015 The three dimensional conformation of the genome in the cell nucleus influences important biological processes such as gene expression regulation. Recent studies have shown a strong correlation between chromatin interactions and gene co-expression ...
Sepideh Babaei +5 more
doaj +3 more sources
Open chromatin interaction maps reveal functional regulatory elements and chromatin architecture variations during wheat evolution [PDF]
Genome Biology, 2022 Background Bread wheat (Triticum aestivum) is an allohexaploid that is generated by two subsequent allopolyploidization events. The large genome size (16 Gb) and polyploid complexity impede our understanding of how regulatory elements and their ...
Jingya Yuan +11 more
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Topological structure analysis of chromatin interaction networks [PDF]
BMC Bioinformatics, 2019 Background Current Hi-C technologies for chromosome conformation capture allow to understand a broad spectrum of functional interactions between genome elements.
Juris Viksna +9 more
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Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction [PDF]
ImmunityLiu S +12 more
exaly +2 more sources
Integrative Ranking of Enhancer Networks Facilitates the Discovery of Epigenetic Markers in Cancer
Frontiers in Genetics, 2021 Regulation of gene expression through multiple epigenetic components is a highly combinatorial process. Alterations in any of these layers, as is commonly found in cancer diseases, can lead to a cascade of downstream effects on tumor suppressor or ...
Qi Wang +6 more
doaj +1 more source
Three-Dimensional Genome Map of the Filamentous Fungus Penicillium oxalicum
Microbiology Spectrum, 2022 Higher-order spatial organization of the chromatin in the nucleus plays crucial roles in the maintenance of cell functions and the regulation of gene expression. Three-dimensional (3D) genome sequencing has been used to great effect in mammal and plants,
Cheng-Xi Li +5 more
doaj +1 more source
Cell Reports, 2022 Summary: The spliceosome is a large ribonucleoprotein complex responsible for pre-mRNA splicing and genome stability maintenance. Disruption of the spliceosome activity may lead to developmental disorders and tumorigenesis.
Gui-Xin Ruan +8 more
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Chromatin Hubs: A biological and computational outlook
Computational and Structural Biotechnology Journal, 2022 This review discusses our current understanding of chromatin biology and bioinformatics under the unifying concept of “chromatin hubs.” The first part reviews the biology of chromatin hubs, including chromatin–chromatin interaction hubs, chromatin hubs ...
Antonio Mora +4 more
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Genome Biology, 2021 Chromatin interactions play important roles in regulating gene expression. However, the availability of genome-wide chromatin interaction data is limited.
Fan Cao +11 more
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