Results 41 to 50 of about 259,952 (309)
Papillomavirus interaction with cellular chromatin [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010 High-risk human papillomavirus (HPV) infection is the primary risk factor for cervical cancer. HPVs establish persistent infection by maintaining their genomes as extrachromosomal elements (episomes) that replicate along with host DNA in infected cells.
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BMC Cell Biology, 2010 Background Regulator of chromosome condensation 1 (RCC1) is the guanine nucleotide exchange factor for Ran GTPase. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear ...
Sanderson Helen S +3 more
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Microscale Thermophoresis Analysis of Chromatin Interactions [PDF]
, 2018 Architectural DNA-binding proteins are key to the organization and compaction of genomic DNA inside cells. The activity of architectural proteins is often subject to further modulation and regulation through the interaction with a diverse array of other protein factors.
Corbeski, I. +5 more
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3C-Based Chromatin Interaction Analyses [PDF]
Cold Spring Harbor Protocols, 2018 This introduction presents a molecular approach that uses formaldehyde cross-linking to investigate genome structure and function—chromosome conformation capture (3C). This approach allows us to determine the spatial proximity of distant functional genomic sites (by looping).
Kim, Tae Hoon, Dekker, Job
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Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity [PDF]
, 2011 Genomic maps of chromatin modifications have provided evidence for the partitioning of genomes into domains of distinct chromatin states, which assist coordinated gene regulation.
West, A. +8 more
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Histone methylation by PRC2 is inhibited by active chromatin marks [PDF]
, 2013 Chromatin modifiers serve as regulatory switches that control the cell cycle, maintain pluripotency and drive differentiation and development. Positive feedback mechanisms help to pass on transcriptional information from one generation of cells to the ...
Schmitges, Frank W.
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Chromatin structure and gene transcription of recombinant p53 adenovirus vector within host
Frontiers in Molecular BiosciencesIntroductionThe recombinant human p53 adenovirus (Ad-p53) offers a promising approach for cancer therapy, yet its chromatin structure and effects on host chromatin organization and gene expression are not fully understood.MethodsIn this study, we ...
Duo Ning +2 more
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Actin-Related Protein 4 and Linker Histone Sustain Yeast Replicative Ageing
Cells, 2022 Ageing is accompanied by dramatic changes in chromatin structure organization and genome function. Two essential components of chromatin, the linker histone Hho1p and actin-related protein 4 (Arp4p), have been shown to physically interact in ...
Mateusz Mołoń +11 more
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ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Chioda, Mariacristina +2 more
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Cell Reports, 2018 Summary: The pluripotent state of embryonic stem cells (ESCs) is defined by its transcriptome and epigenome. The chromatin reader Brd4 determines ESC identity.
Tao Wu +2 more
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