Results 51 to 60 of about 259,952 (309)

Interaction of the Glucocorticoid Receptor with the Chromatin Landscape [PDF]

Molecular Cell, 2008
The generality and spectrum of chromatin-remodeling requirements for nuclear receptor function are unknown. We have characterized glucocorticoid receptor (GR) binding events and chromatin structural transitions across GR-induced or -repressed genes. This analysis reveals that GR binding invariably occurs at nuclease-accessible sites (DHS). A remarkable
John, S, Sabo, P, Johnson, TA, Sung, M-H, Biddie, SC, Lightman, SL, Voss, TC, Davis, SR, Meltzer, PS, Stamatoyannopoulos, JA, Hager, GL   +10 more
openaire   +3 more sources

Analysis of β-globin chromatin micro-environment using a novel 3C variant, 4Cv [PDF]

, 2010
Copyright: © 2010 Pink et al.Higher order chromatin folding is critical to a number of developmental processes, including the regulation of gene expression.
Christopher H Eskiw, Christopher H. Eskiw, David R F Carter, Eskiw, CH, Daniel P Caley, Pink Ryan C., David R. F. Carter, Caley, DP, Ryan C Pink, Caley, D, Carter, D, Daniel P. Caley, Eskiw Christopher H., Caley Daniel P., Pink, R, Ryan C. Pink, Eskiw, C, Carter David R. F.   +17 more
core   +1 more source

Studies on the binding affinity of anticancer drug mitoxantrone to chromatin, DNA and histone proteins

Journal of Biomedical Science, 2009
Mitoxantrone is a potent antitumor drug, widely used in the treatment of various cancers. In the present study, we have investigated and compared the affinity of anticancer drug, mitoxantrone, to EDTA-soluble chromatin (SE-chromatin), DNA and histones ...
Rabbani-Chadegani Azra, Hajihassan Zahra
doaj   +1 more source

Effect of DNA groove binder distamycin A upon chromatin structure. [PDF]

PLoS ONE, 2011
BACKGROUND: Distamycin A is a prototype minor groove binder, which binds to B-form DNA, preferentially at A/T rich sites. Extensive work in the past few decades has characterized the binding at the level of double stranded DNA.
Parijat Majumder, Dipak Dasgupta
doaj   +1 more source

Most chromatin interactions are not in linkage disequilibrium [PDF]

Genome Research, 2019
Chromatin interactions and linkage disequilibrium (LD) are both pairwise measurements between genomic loci that show block patterns along mammalian chromosomes. Their values are generally high for sites that are nearby in the linear genome but abruptly drop across block boundaries.
Whalen, Sean, Pollard, Katherine S
openaire   +4 more sources

Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms [PDF]

, 2007
Alteration of chromatin structure by chromatin modifying and remodelling activities is a key stage in the regulation of many nuclear processes. These activities are frequently interlinked, and many chromatin remodelling enzymes contain motifs that ...
Owen-Hughes, Tom; id_orcid, Flaus, Andrew, Ferreira, Helder, Owen-Hughes, Tom   +3 more
core   +1 more source

Structure and Function of PML Nuclear Bodies: A Brief Overview of Key Cellular Roles

Biomolecules
Promyelocytic leukemia nuclear bodies (PML-NBs) are dynamic membrane-less organelles (MLOs) located in the nucleus that serve as regulatory hubs for multiple cellular processes.
Karolina Dorosz, Lidia Majewska, Jacek Kijowski   +2 more
doaj   +1 more source

Proximity Labeling Techniques to Study Chromatin

Frontiers in Genetics, 2020
Mammals contain over 200 different cell types, yet nearly all have the same genomic DNA sequence. It is a key question in biology how the genetic instructions in DNA are selectively interpreted by cells to specify various transcriptional programs and ...
Henning Ummethum, Stephan Hamperl
doaj   +1 more source

Functional interactions between nucleoporins and chromatin [PDF]

Current Opinion in Cell Biology, 2011
As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years, transport-independent functions of NPC components, nucleoporins, have been identified including roles in chromatin organization and gene regulation. Here, we summarize our current
Yun, Liang, Martin W, Hetzer
openaire   +2 more sources

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains [PDF]

, 2011
The ATP-dependent chromatin-remodelling enzyme Chd1 is a 168-kDa protein consisting of a double chromodomain, Snf2-related ATPase domain, and a C-terminal DNA-binding domain.
Daniel P Ryan, Singh, Vijender, Owen-Hughes, Tom; id_orcid, Martin, David; id_orcid, David Martin, Ramasubramanian Sundaramoorthy, Vijender Singh, Sundaramoorthy, Ramasubramanian, Ryan, Daniel P., Tom Owen-Hughes   +9 more
core   +1 more source