Results 61 to 70 of about 259,952 (309)

Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis

Cell Genomics
Summary: The precise roles of chromatin organization at osteoporosis risk loci remain largely elusive. Here, we combined chromatin interaction conformation (Hi-C) profiling and self-transcribing active regulatory region sequencing (STARR-seq) to qualify ...
Xiao-Feng Chen, Yuan-Yuan Duan, Ying-Ying Jia, Qian-Hua Dong, Wei Shi, Yan Zhang, Shan-Shan Dong, Meng Li, Zhongbo Liu, Fei Chen, Xiao-Ting Huang, Ruo-Han Hao, Dong-Li Zhu, Rui-Hua Jing, Yan Guo, Tie-Lin Yang   +15 more
doaj   +1 more source

ChIAMM: A Mixture Model for Statistical Analysis of Long-Range Chromatin Interactions From ChIA-PET Experiments

Frontiers in Genetics, 2020
Chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) is an important experimental method for detecting specific protein-mediated chromatin loops genome-wide at high resolution. Here, we proposed a new statistical approach with a mixture
Yibeltal Arega, Hao Jiang, Shuangqi Wang, Jingwen Zhang, Xiaohui Niu, Guoliang Li, Guoliang Li   +6 more
doaj   +1 more source

4DGenome: a comprehensive database of chromatin interactions [PDF]

Bioinformatics, 2015
Abstract Motivation: The 3D structure of the genome plays a critical role in regulating gene expression. Recent progress in mapping technologies for chromatin interactions has led to a rapid increase in this kind of interaction data. This trend will continue as research in this burgeoning field intensifies.
Li Teng, Bing He, Jiahui Wang, Kai Tan 0001   +3 more
openaire   +4 more sources

Identification and validation of transcription factors that regulate chromatin dynamics [PDF]

, 2012
Gene expression has to be tightly regulated during all cellular processes. During embryonic development differentiating cells loose their developmental potential and acquire specific functions by activating lineage-specific genes.
Schöler, Anne
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Human transcriptional interactome of chromatin contribute to gene co-expression

BMC Genomics, 2010
Background Transcriptional interactome of chromatin is one of the important mechanisms in gene transcription regulation. By chromatin conformation capture and 3D FISH experiments, several chromatin interactions cases among sequence-distant genes or even ...
Chen Yunqin, Li Chao, Dong Xiao, Ding Guohui, Li Yixue   +4 more
doaj   +1 more source

Interaction of RSC Chromatin Remodeling Complex with Nucleosomes Is Modulated by H3 K14 Acetylation and H2B SUMOylation In Vivo

iScience, 2020
Summary: Chromatin remodeling complexes are multi-subunit nucleosome translocases that reorganize chromatin in the context of DNA replication, repair, and transcription.
Neha Jain, Davide Tamborrini, Brian Evans, Shereen Chaudhry, Bryan J. Wilkins, Heinz Neumann   +5 more
doaj   +1 more source

Identification of enhancers responsible for the coordinated expression of myosin heavy chain isoforms in skeletal muscle

BMC Genomics, 2022
Background Skeletal muscles consist of fibers of differing contractility and metabolic properties, which are primarily determined by the content of myosin heavy chain (MYH) isoforms (MYH7, MYH2, MYH1, and MYH4).
Keren Long, Duo Su, Xiaokai Li, Hengkuan Li, Sha Zeng, Yu Zhang, Zhining Zhong, Yu Lin, Xuemin Li, Lu Lu, Long Jin, Jideng Ma, Qianzi Tang, Mingzhou Li   +13 more
doaj   +1 more source

NoRC, a novel chromatin remodeling complex involved in ribosomal RNA gene silencing [PDF]

, 2004
Regulation of gene expression takes place in the nucleus in a highly structured and condensed nucleoprotein environment, called chromatin (Felsenfeld and Groudine, 2003; Khorasanizadeh, 2004; Vaquero et al., 2003).
Strohner, Ralf
core  

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation [PDF]

, 2010
Background: Brahma-related gene 1 (Brg1, also known as Smarca4 and Snf2 beta) encodes an adenosine-5'-triphosphate (ATP)-dependent catalytical subunit of the (switch/sucrose nonfermentable) (SWI/SNF) chromatin remodeling complexes.
He, Shuying, Metzger, Daniel, Wolf Louise, Bharesh K Chauhan, Chambon, Pierre, Ruth Ashery-Padan, Nakai, Akira, Zavadil, Jiri, Cveklova Kveta, Daniel Metzger, Ernst R Tamm, Chauhan Bharesh K, Metzger Daniel, Melinda K Pirity, Wang Wei-Lin, Chauhan, Bharesh K., Pierre Chambon, Cveklova, Kveta, Cvekl Ales, Akira Nakai, Ales Cvekl, Pirity Melinda K, Wolf, Louise, Tamm, Ernst R., Ashery-Padan, Ruth, Cvekl, Ales, Chambon Pierre, Wang, Wei-Lin, Wei-Lin Wang, Ashery-Padan Ruth, Nakai Akira, He Shuying, Shuying He, Kveta Cveklova, Zavadil Jiri, Louise Wolf, Tamm Ernst R, Jiri Zavadil, Pirity, Melinda K.   +38 more
core   +1 more source