Results 11 to 20 of about 259,952 (309)
Interaction of mithramycin with chromatin.
Indian journal of biochemistry & biophysics, 2001 Mithramycin (MTR) is an anti-cancer antibiotic that blocks the macromolecular biosynthesis via reversible interaction with DNA template in the presence of bivalent metal ion such as Mg2+. In absence of DNA, mithramycin forms two types of complexes with Mg2+, complex I (with 1:1 stoichiometry in terms of MTR: Mg2+) and complex II (with 1:2 stoichiometry
M A, Mir, D, Dasgupta
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Untangling chromatin interactions [PDF]
Journal of Experimental Botany, 2020 The plant nucleus contains myriad subdomains that define and are defined by the composition of their chromatin. On a whole nucleus scale, this includes regions of active euchromatin and inactive heterochromatin, although the boundaries between these states are blurred.
Parry, Geraint +3 more
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Insights into HP1a-Chromatin Interactions [PDF]
Cells, 2020 Understanding the packaging of DNA into chromatin has become a crucial aspect in the study of gene regulatory mechanisms. Heterochromatin establishment and maintenance dynamics have emerged as some of the main features involved in genome stability, cellular development, and diseases. The most extensively studied heterochromatin protein is HP1a.
Silvia Meyer-Nava +3 more
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Epigenetics & Chromatin: interactions and processes [PDF]
Epigenetics & Chromatin, 2013 On 11 to 13 March 2013, BioMed Central will be hosting its inaugural conference, Epigenetics & Chromatin: Interactions and Processes, at Harvard Medical School, Cambridge, MA, USA. Epigenetics & Chromatin has now launched a special article series based on the general themes of the conference.
Henikoff, S, Grosveld, Frank
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Interactions of Cisplatin and Daunorubicin at the Chromatin Level [PDF]
Scientific Reports, 2020 Abstract Unexpectedly, the widely used anticancer agents Cisplatin (Cis-Pt) and Daunorubicin (Dauno) exhibited cell type- and concentration-dependent synergy or antagonism in vitro . We attempted to interpret these effects in terms of the changes elicited by the drugs in the
Erfaneh Firouzi Niaki +7 more
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Long-Range Chromatin Interactions [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 To accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes ...
Dekker, Job, Misteli, Tom
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Cells, 2020 The forkhead box (Fox) transcription factors (TFs) are widespread from yeast to humans. Their mutations and dysregulation have been linked to a broad spectrum of malignant neoplasias.
Yue Jin, Zhangqian Liang, Huiqiang Lou
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Cohesin-Mediated Chromatin Interactions and Autoimmunity [PDF]
Frontiers in Immunology, 2022 Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-binding factor, it ensures insulator activity to organize enhancers and promoters within regulatory
Venkataragavan Chandrasekaran +12 more
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Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]
, 2005 The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton +2 more
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Liquid chromatin Hi-C characterizes compartment-dependent chromatin interaction dynamics. [PDF]
Nat Genet, 2021 Nuclear compartmentalization of active and inactive chromatin is thought to occur through microphase separation mediated by interactions between loci of similar type. The nature and dynamics of these interactions are not known.
Belaghzal H +7 more
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