Results 1 to 10 of about 357,335 (290)
DeepRCI: predicting RNA‐chromatin interactions via deep learning with multi‐omics data [PDF]
Quantitative Biology, 2023 Chromatin‐associated RNA (caRNA) acts as a ubiquitous epigenetic layer in eukaryotes, and has been reported to be essential in various biological processes.
Yuanpeng Xiong +4 more
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Noncoding de novo mutations contribute to autism via long-range chromatin interactions [PDF]
European Psychiatry, 2023 Introduction Three-dimensional chromatin interactions regulate gene expressions. The significance of de novo mutations (DNMs) in chromatin interactions remains poorly understood for autism spectrum disorder (ASD).
I. B. Kim +4 more
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MAPS: Model-based analysis of long-range chromatin interactions from PLAC-seq and HiChIP experiments. [PDF]
PLoS Computational Biology, 2019 Hi-C and chromatin immunoprecipitation (ChIP) have been combined to identify long-range chromatin interactions genome-wide at reduced cost and enhanced resolution, but extracting information from the resulting datasets has been challenging.
Ivan Juric +12 more
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Chromatin Accessibility and Interactions in the Transcriptional Regulation of T Cells
Frontiers in Immunology, 2018 During T cell differentiation and activation, specific stimuli, and a network of transcription factors (TFs) are involved in orchestrating chromatin accessibility, establishing enhancer-promoter interactions, and regulating gene expression. Over the past
Peng Li, Warren J. Leonard
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Global quantitative modeling of chromatin factor interactions.
PLoS Computational Biology, 2014 Chromatin is the driver of gene regulation, yet understanding the molecular interactions underlying chromatin factor combinatorial patterns (or the "chromatin codes") remains a fundamental challenge in chromatin biology.
Jian Zhou, Olga G Troyanskaya
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Footprint-C reveals transcription factor modes in local clusters and long-range chromatin interactions [PDF]
Nature CommunicationsThe proximity ligation-based Hi-C and derivative methods are the mainstream tools to study genome-wide chromatin interactions. These methods often fragment the genome using enzymes functionally irrelevant to the interactions per se, restraining the ...
Xiaokun Liu +5 more
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3D chromatin interactions involving Drosophila insulators are infrequent but preferential and arise before TADs and transcription [PDF]
Nature Communications, 2023 In mammals, insulators contribute to the regulation of loop extrusion to organize chromatin into topologically associating domains. In Drosophila the role of insulators in 3D genome organization is, however, under current debate.
Olivier Messina +5 more
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Cells, 2022 Three-dimensional genome organization represents an additional layer in the epigenetic regulation of gene expression. Active transcription controlled by enhancers or super-enhancers has been extensively studied.
Ying Zhang +3 more
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Biology, 2023 Cadherins are cell–cell adhesion molecules, fundamental for cell architecture and polarity. E-cadherin to P-cadherin switch can rescue adherens junctions in epithelial tumours.
Celina São José +7 more
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Genome Biology, 2021 Chromatin interactions play important roles in regulating gene expression. However, the availability of genome-wide chromatin interaction data is limited.
Fan Cao +11 more
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