Results 141 to 150 of about 94,335 (243)
Advanced Science, EarlyView.This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li +15 more
wiley +1 more source
Publisher Correction: Super‑resolution visualization of chromatin loop folding in human lymphoblastoid cells using interferometric photoactivated localization microscopy. [PDF]
Sci Rep, 2022 Parteka-Tojek Z +9 more
europepmc +1 more source
Advanced Science, EarlyView.A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma +11 more
wiley +1 more source
Looping by RNA: Dynamic control of the chromatin loop by long non-coding RNAs in plants. [PDF]
Mol Plant, 2021 Kim J, Sung S.
europepmc +1 more source
Advanced Science, EarlyView.Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Jiaxuan Sui +7 more
wiley +1 more source
Genome-wide absolute quantification of chromatin looping
3D genomics methods such as Hi-C and Micro-C have uncovered chromatin loops across the genome and linked these loops to gene regulation. However, these methods only measure 3D interaction probabilities on a relative scale. Here, we overcome this limitation by using live imaging data to calibrate Micro-C in mouse embryonic stem cells, thus obtaining ...
James M. Jusuf +8 more
openaire +2 more sources
Advanced Science, EarlyView.Mechanical intelligence reframes bone regeneration as a time‐dependent coupling between material and cellular memory. Biomaterials store and release mechanical history, while cells retain prior cues and remodel the repair niche. Matching these memories to healing stages may guide stage‐specific scaffolds, sensing‐assisted prediction, mechanical dosing,
Jin Tian +8 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Super-resolution visualization of chromatin loop folding in human lymphoblastoid cells using interferometric photoactivated localization microscopy. [PDF]
Sci Rep, 2022 Parteka-Tojek Z +9 more
europepmc +1 more source
G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation
Advanced Science, EarlyView.G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang +5 more
wiley +1 more source