Results 161 to 170 of about 800,836 (279)

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Boosting the detection of enhancer-promoter loops via normalization methods for chromatin interaction data

Nature Communications
Accurate detection of enhancer-promoter loops from genome-wide chromatin interaction data is critical for understanding gene regulation. Standard normalization methods, such as matrix balancing approaches, are widely used to correct biases in chromatin ...
Xiaotao Wang, Detong Shi, Feiyang Xue, Yunxia Liu, Hongbo Yang, Linghan Jiang   +5 more
doaj   +1 more source

Chromatin loop dynamics during cellular differentiation are associated with changes to both anchor and internal regulatory features. [PDF]

Genome Res, 2023
Bond ML, Davis ES, Quiroga IY, Dey A, Kiran M, Love MI, Won H, Phanstiel DH.   +7 more
europepmc   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Loop, Floyd D. -- 1975-93 -- Correspondence, Individual -- letter, 1984-03-13

, 1984
Letter from Loop, Floyd D. to Sabin, Albert B.
Loop, Floyd D.
core   +1 more source

Looping, Linking, and Chromatin Activity [PDF]

Cell, 2000
Engel, James Douglas, Tanimoto, Keiji
openaire   +1 more source

Table1_CD-Loop: a chromatin loop detection method based on the diffusion model.DOCX

MotivationIn recent years, there have been significant advances in various chromatin conformation capture techniques, and annotating the topological structure from Hi-C contact maps has become crucial for studying the three-dimensional structure of ...
Yang Wang (5921), Jiquan Shen (11788193), Junwei Luo (7593224)   +2 more
core   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Loop, Floyd D. -- 1975-93 -- Correspondence, Individual -- letter, 1990-07-25

, 1990
Letter from Loop, Floyd D. to Sabin, Albert B.
Loop, Floyd D.
core   +1 more source

The structural role of histone H2A variants in chromatin function

, 2008
Chromatin is a highly dynamic complex that facilitates the structural transitions required for specific gene expression. An emerging player in the regulation of such chromatin functions are histone H2A variants.
Abbott, D. Wade
core