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Chromatin Loops in Gene Regulation [PDF]
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2009 The control of gene expression involves regulatory elements that can be very far from the genes they control. Several recent technological advances have allowed the direct detection of chromatin loops that juxtapose distant genomic sites in the nucleus.
Gerd A Blobel, Stephan Kadauke
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ZNF143 is a regulator of chromatin loop
Cell Biology and Toxicology, 2018It is known that transcription factor ZNF143 frequently co-binds with CTCF-Cohesin complex in the anchor regions of chromatin loops. However, there is currently no genome-wide experiment to explore the functional roles of ZNF143 in chromatin loops. In this work, we used both computational and experimental analyses to investigate the regulatory effect ...
Zi Wen +3 more
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Chromatin looping and the probability of transcription
Trends in Genetics, 2006Recent studies of several multigene clusters have shown that gene activation by a remote enhancer is associated with chromatin loop formation. It is not fully understood how a chromatin loop forms in a nucleus or how it is involved in gene regulation. In this article, we propose that the major feature that determines loop formation is the flexibility ...
Qiliang, Li +2 more
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Re-defining the chromatin loop domain
Cytogenetic and Genome Research, 2001It is commonly accepted that the loop domain represents the basic structural unit of eukaryotic chromatin associated with DNA replication, gene expression and higher order packaging. However, molecular-cytological information defining the loop domain is lacking. There are gaps in our knowledge of the loop structure and how it regulates gene expression.
H H, Heng +5 more
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The role of chromatin loop extrusion in antibody diversification
Nature Reviews Immunology, 2022Cohesin mediates chromatin loop formation across the genome by extruding chromatin between convergently oriented CTCF-binding elements. Recent studies indicate that cohesin-mediated loop extrusion in developing B cells presents immunoglobulin heavy chain (Igh) variable (V), diversity (D) and joining (J) gene segments to RAG endonuclease through a ...
Yu Zhang +4 more
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Gain of CTCF-Anchored Chromatin Loops Marks the Exit From Naive Pluripotency
Cell Systems, 2018 The genome of pluripotent stem cells adopts a unique three-dimensional architecture featuring weakly condensed heterochromatin and large nucleosome-free regions. Yet, it is unknown whether structural loops and contact domains display characteristics that
Paul Bertone +2 more
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Chromatin loops, illegitimate recombination, and genome evolution
BioEssays, 2009AbstractChromosomal rearrangements frequently occur at specific places (“hot spots”) in the genome. These recombination hot spots are usually separated by 50–100 kb regions of DNA that are rarely involved in rearrangements. It is quite likely that there is a correlation between the above‐mentioned distances and the average size of DNA loops fixed at ...
Omar L, Kantidze, Sergey V, Razin
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Chromatin Loops Facilitate Co-Regulation of Paralogues
Nature Reviews GeneticsHenry Ertl
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Analysis of Chromatin Interaction and Accessibility by Trac-Looping
2023Spatial organization of the genome modulates pivotal biological processes. The emerging new technologies have provided novel insights into genome structure and its role in regulating cell activities. To examine the genome-wide chromatin interactions at accessible chromatin regions, we developed a DNA transposase-mediated analysis of chromatin looping ...
Shuai, Liu, Qingsong, Tang, Keji, Zhao
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