Results 111 to 120 of about 303,776 (147)

Improved cohesin HiChIP protocol and bioinformatic analysis for robust detection of chromatin loops and stripes

Communications Biology
Chromosome Conformation Capture (3 C) methods, including Hi-C (a high-throughput variation of 3 C), detect pairwise interactions between DNA regions, enabling the reconstruction of chromatin architecture in the nucleus. HiChIP is a modification of the Hi-
Karolina Buka, Zofia Parteka-Tojek, Abhishek Agarwal, Michał Denkiewicz, Sevastianos Korsak, Mateusz Chiliński, Krzysztof H. Banecki, Dariusz Plewczynski   +7 more
doaj   +1 more source

Chromatin Loop [PDF]

, 2020
openaire   +1 more source

DconnLoop: a deep learning model for predicting chromatin loops based on multi-source data integration

BMC Bioinformatics
Background Chromatin loops are critical for the three-dimensional organization of the genome and gene regulation. Accurate identification of chromatin loops is essential for understanding the regulatory mechanisms in disease.
Junfeng Wang, Kuikui Cheng, Chaokun Yan, Huimin Luo, Junwei Luo   +4 more
doaj   +1 more source

Chromomeres, Topologically Associating Domains and Structural Organization of Chromatin Bodies in Somatic Nuclei (Macronuclei) of Ciliates

Frontiers in Bioscience-Landmark
Background: In the twentieth century, the textbook idea of packaging genomic material in the cell nucleus and metaphase chromosomes was the presence of a hierarchy of structural levels of chromatin organization: nucleosomes ...
Vladimir Popenko, Pavel Spirin, Vladimir Prassolov, Olga Leonova   +3 more
doaj   +1 more source

Looping, Linking, and Chromatin Activity [PDF]

Cell, 2000
Engel, James Douglas, Tanimoto, Keiji
openaire   +1 more source

Transcriptionally active chromatin loops contain both ‘active’ and ‘inactive’ histone modifications that exhibit exclusivity at the level of nucleosome clusters

Epigenetics & Chromatin
Chromatin state is thought to impart regulatory function to the underlying DNA sequence. This can be established through histone modifications and chromatin organisation, but exactly how these factors relate to one another to regulate gene expression is ...
Stefan A. Koestler, Madeleine L. Ball, Leila Muresan, Vineet Dinakaran, Robert White   +4 more
doaj   +1 more source

The size of chromatin loops in HeLa cells.

, 2016
It is widely believed that the chromatin fibre is organized into loops during interphase, with the loop being implicated as an important unit of nuclear function.

core  

Mapping Chromatin Loops in Single Cells [PDF]

Trends in Genetics, 2022
Recent advances in high-throughput chromatin conformation capture (Hi-C) technologies at the single-cell level enable the identification of cell type-specific chromatin loops directly from complex tissues. This may help to interpret noncoding variants identified by genome-wide association studies (GWAS) in disease-relevant cell types. We briefly review
Ming Hu, Miao Yu
exaly   +4 more sources

Nascent Connections: R-Loops and Chromatin Patterning [PDF]

Trends in Genetics, 2016
RNA molecules, such as long noncoding RNAs (lncRNAs), have critical roles in regulating gene expression, chromosome architecture, and the modification states of chromatin. Recent developments suggest that RNA also influences gene expression and chromatin patterns through the interaction of nascent transcripts with their DNA template via the formation ...
Frederic Chedin
exaly   +7 more sources

Some of the next articles are maybe not open access.

Related searches:

Keeping Chromatin in the Loop(s)

Nature Reviews Molecular Cell Biology, 2021
Eukaryotic chromosomes are huge DNA polymers organized in space and time. Chromatin looping compacts these polymers, helps genome organization by the formation of enhancer–promoter and other interactions, and emerges when genes are highly expressed. Thus, several types of chromatin loops exist, which vary in structure, maintenance and function. Solovei
Leonid Mirny, Irina Solovei
exaly   +3 more sources