Results 91 to 100 of about 303,776 (147)

Additional file 3 of Open chromatin interaction maps reveal functional regulatory elements and chromatin architecture variations during wheat evolution

, 2022
Additional file 3: Table S4 The intrachromosomal open chromatin ...
Jingya Yuan (9668621), Guanghong Jia (3523712), Lulu Li (608444), Haojie Sun (4516129), Yijin Wang (6115649), Junrong Mao (11996516), Xiue Wang (111266), Wu Jiao (9668624), Zhongfu Ni (48118), Shiting Chen (11996513), Longfei Wang (217360), Qingxin Song (11996519)   +11 more
core   +1 more source

Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans

Nature Communications
Chromatin topology can impact gene regulation, but how evolutionary divergence in chromatin topology has shaped gene regulatory landscapes for distinctive human traits remains poorly understood.
Xia Wu, Dan Xiong, Rong Liu, Xingqiang Lai, Yuhan Tian, Ziying Xie, Li Chen, Lanqi Hu, Jingjing Duan, Xinyu Gao, Xian Zeng, Wei Dong, Ting Xu, Fang Fu, Xin Yang, Xinlai Cheng, Dariusz Plewczynski, Minji Kim, Wenjun Xin, Tianyun Wang, Andy Peng Xiang, Zhonghui Tang   +21 more
doaj   +1 more source

Genomic Looping: A Key Principle of Chromatin Organization

Microbial Physiology, 2014
The effective volume occupied by the genomes of all forms of life far exceeds that of the cells in which they are contained. Therefore, all organisms have developed mechanisms for compactly folding and functionally organizing their genetic material. Through recent advances in fluorescent microscopy and 3C-based technologies, we finally have a first ...
Ramon A, van der Valk, Jocelyne, Vreede, Frédéric, Crémazy, Remus T, Dame   +3 more
openaire   +2 more sources

CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism

Nucleus, 2020
Mammalian genome structure is closely linked to function. At the scale of kilobases to megabases, CTCF and cohesin organize the genome into chromatin loops.
Anders S. Hansen
doaj   +1 more source

Chromatin loops containing VDR binding sites.

, 2014
The IGV browser was used to display the chromatin loops around the genes ZFP36 (A), SFT2D1 (B), SEPT3 (C) and SP100 (D). VDR ChIP-seq data from THP-1 cells [7] (unstimulated (−) and treated for 40 min with 1,25(OH)2D3 (+), red) are shown in comparison ...
Sabine Seuter (438740), Carsten Carlberg (7997), Antonio Neme (555493)   +2 more
core   +1 more source

CellLoop: Identifying single-cell 3D genome chromatin loops

Nature Communications
Single-cell 3D genome technologies provide unprecedented views of chromatin architecture, but the extreme sparsity and noise of contact maps limit robust detection of chromatin loops at the individual cell level. Here we present CellLoop, a computational
Yusen Ye, Yiheng Wang, Shiji Liu, Yuxuan Hu, Liang Yu, Weibing Wang, Shihua Zhang, Hebing Chen, Lin Gao   +8 more
doaj   +1 more source

An holomorphic study of Smarandache automorphic and cross inverse property loops [PDF]

, 2008
By studying the holomorphic structure of automorphic inverse property uasigroups and loops[AIPQ and (AIPL)] and cross inverse property quasigroups and loops[CIPQ and (CIPL)], it is established that the holomorph of a loop is a Smarandache; AIPL, CIPL, K ...
Gbolahan, Temitoe, Temitope Gbolahan Jaiyeola   +1 more
core   +1 more source

CLAMP: predicting specific protein-mediated chromatin loops in diverse species with a chromatin accessibility language model

Genome Biology
Emerging DNA language models provide powerful tools to address the challenge of accurately predicting chromatin loops, fundamental structures governing 3D genome organization and gene regulation.
Zhijie He, Yu Sun, Hao Li, Canzhuang Sun, Xianhui Yang, Hebing Chen, Mingzhi Liao, Xiaochen Bo   +7 more
doaj   +1 more source

Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains

, 1992
It has been proposed that scaffold-associated regions are DNA elements that form the bases of chromatin loops in eukaryotic cells. Recent evidence supports a role for these elements as cis-acting ‘handlers' of both structural and functional chromatin ...
Kaes, Emmanuel, Poljak-Carpousis, Leonora Gabriela, Laemmli, Ulrich Karl, Adachi, Yasuhisa, Laemmli UK, Poljak L, Käs E, Adachi Y   +7 more
core   +1 more source

TM-Loop: Transformer multi-omics hierarchical detection of chromatin loop

Scientific Reports
Abstract Chromatin loops form the hierarchical 3D genome architecture and act as critical regulatory hubs, bringing distant cis-elements together to precisely control target gene transcription. Disruption of these spatial interactions is closely linked to human diseases including cancer. Hi-C provides genome-wide interaction maps, yet
Zhai, Haixia, Yang, Hao, Hou, Zhanwei, Liu, Xiaoyan, Wang, Junfeng   +4 more
openaire   +3 more sources