Results 81 to 90 of about 329,145 (275)

Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]

, 2005
The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton, Becker, Peter, Ferreira, Roger   +2 more
core   +1 more source

Comparison of chromatin loops within individual cell types.

, 2022
(a) Distance distribution of DLoopCaller identified chromatin loops from Hi-C contact maps by using CTCF ChIA-PET, H3K27ac HiChIP, SMC1 HiChIP, RAD ChIA-PET, and promoter Capture Hi-C data after training on GM12878.
Qinhu Zhang (12219347), Kyungsook Han (19287), Ying He (125930), Zhen Cui (2966148), De-Shuang Huang (396909), Siguo Wang (12219350), Zhenghao Guo (7238795)   +6 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

An holomorphic study of Smarandache automorphic and cross inverse property loops [PDF]

, 2008
By studying the holomorphic structure of automorphic inverse property uasigroups and loops[AIPQ and (AIPL)] and cross inverse property quasigroups and loops[CIPQ and (CIPL)], it is established that the holomorph of a loop is a Smarandache; AIPL, CIPL, K ...
Gbolahan, Temitoe, Temitope Gbolahan Jaiyeola   +1 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

High-resolution chromatin mapping reveals that CTCF anchors meiotic loops to the chromosome axis

Nature Communications
When precursor germ cells enter meiosis, chromosomes condense into an array of chromatin loops. Using Hi-C and Micro-C, we explored the trajectory of chromatin reorganization from mouse spermatogonia to spermatocytes at the highest temporal and spatial ...
Gang Cheng, Xin Li, Kevin Brick, Benjamin Alleva, Mini Huang, Kwan-Wood Gabriel Lam, Florencia Pratto, R. Daniel Camerini-Otero   +7 more
doaj   +1 more source

RNA stabilizes transcription-Dependent Chromatin Loops Induced By Nuclear Hormones [PDF]

, 2019
We show that transcription induced by nuclear receptors for estrogen (e2) or retinoic acid (RA) is associated with formation of chromatin loops that juxtapose the 5’ end (containing the promoter) with the enhancer and the 3′ polyA addition site of the ...
TRAMONTANO, ALFONSO, Antonella Romano, DE ROSA, MARIAROSARIA, Antonio pezone, Maria Vinciguerra, Enrico V. Avvedimento, Antonio porcellini, Max e. Gottesman, Candida Zuchegna, Giusi Russo   +9 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Repulsive forces between looping chromosomes induce entropy-driven segregation. [PDF]

PLoS ONE, 2011
One striking feature of chromatin organization is that chromosomes are compartmentalized into distinct territories during interphase, the degree of intermingling being much smaller than expected for linear chains.
Manfred Bohn, Dieter W Heermann
doaj   +1 more source