Linking Differential Chromatin Loops to Transcriptional Decisions [PDF]
Molecular Cell, 2008 GATA-1 and GATA-2 control proliferation and differentiation of hematopoietic progenitor cells via transcriptional regulation. In this issue of Molecular Cell, Jing et al. (2008) demonstrate that GATA factor exchange on the Kit locus directs a transcriptional switch by reconfiguring chromatin loops.
Apostolou, Effie, Thanos, Dimitris
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Chromatin loop anchors contain core structural components of the gene expression machinery in maize
BMC Genomics, 2021 Background Three-dimensional chromatin loop structures connect regulatory elements to their target genes in regions known as anchors. In complex plant genomes, such as maize, it has been proposed that loops span heterochromatic regions marked by higher ...
Stéphane Deschamps +7 more
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Kinetic control of eukaryotic chromatin structure by recursive topological restraints [PDF]
, 2008 Chromatin structure undergoes many changes during the cell cycle and in response to regulatory events. A basic unit of chromatin organization is the nucleosome core particle.
Dominika Borek, Zbyszek Otwinowski
core
Replication forks, chromatin loops and dormant replication origins [PDF]
, 2008 When DNA replication is slowed down, normally dormant replication origins are activated. Recent work demonstrates that cells adapt by changing the organization of chromatin loops and maintaining the new pattern of origin use in subsequent cell cycles.
Blow, J. Julian; id_orcid +5 more
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Analysis of β-globin chromatin micro-environment using a novel 3C variant, 4Cv [PDF]
, 2010 Copyright: © 2010 Pink et al.Higher order chromatin folding is critical to a number of developmental processes, including the regulation of gene expression.
Christopher H Eskiw +17 more
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Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping
Nature Communications, 2017 Chromatin looping plays an important role in gene regulation and the ability to manipulate loops would aid in understanding how this occurs. Here the authors present CLOuD9, a system that uses dimerized Cas9 complexes to selectively and reversibly ...
Stefanie L. Morgan +13 more
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Detection of TERRA R-Loops at Human Telomeres
, 2022 R-loops are three-stranded nucleic acid structures composed of a DNA–RNA hybrid and a displaced DNA strand. The long noncoding RNA TERRA forms R-loops at telomeres influencing the telomeric chromatin composition and impacting on telomere maintenance ...
Lingner, Joachim +7 more
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Pericentric Chromatin Is Organized into an Intramolecular Loop in Mitosis [PDF]
Current Biology, 2008 Cohesin proteins link sister chromatids and provide the basis for tension between bi-oriented sister chomatids in mitosis. Cohesin is concentrated at the centromere region of the chromosome despite the fact that sister centromeres can be separated by 800nm in vivo. The function of cohesin at sites of separated DNA is unknown.
Yeh, Elaine +7 more
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Structural characterization of chromatin loops.
, 2019 (A) Probability distribution of the end-to-end distance for the chromatin loop formed between chr1:39.56 Mb and chr1:39.73 Mb from GM12878 cells (blue) and for a random genomic pair (yellow).
Yifeng Qi (6817691), Bin Zhang (64682)
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ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL. [PDF]
, 2019 Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL.
Roitinger, Elisabeth +19 more
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