Results 41 to 50 of about 329,145 (275)
ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL
eLife, 2020 Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL.
Gordana Wutz +19 more
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Proteomic interrogation of human chromatin. [PDF]
, 2011 Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. Here,
LeRoy, Gary +22 more
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Histone methylation by PRC2 is inhibited by active chromatin marks [PDF]
, 2013 Chromatin modifiers serve as regulatory switches that control the cell cycle, maintain pluripotency and drive differentiation and development. Positive feedback mechanisms help to pass on transcriptional information from one generation of cells to the ...
Schmitges, Frank W.
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Chromatin loops, gene positioning, and gene expression [PDF]
Frontiers in Genetics, 2012 Technological developments and intense research over the last years have led to a better understanding of the 3D structure of the genome and its influence on genome function inside the cell nucleus. We will summarize topological studies performed on four model gene loci: the α- and β-globin gene loci, the antigen receptor loci, the imprinted H19-Igf2 ...
Holwerda, Sjoerd, Laat, Wouter de
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, 2010 In this paper we study the notion of Smarandache loops. We obtain some interesting results about them. The notion of Smarandache semigroups homomorphism is studied as well in this paper.
Vasantha Kandasamy, W. B.
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SnapHiC2: A computationally efficient loop caller for single cell Hi-C data
Computational and Structural Biotechnology Journal, 2022 Single cell Hi-C (scHi-C) technologies enable the study of chromatin spatial organization directly from complex tissues at single cell resolution.
Xiaoqi Li +7 more
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Scientific Reports, 2022 The three-dimensional (3D) genome structure plays a fundamental role in gene regulation and cellular functions. Recent studies in 3D genomics inferred the very basic functional chromatin folding structures known as chromatin loops, the long-range ...
Zofia Parteka-Tojek +9 more
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Chromatin Switches and Loops [PDF]
Cell, 2013 In the realm of gene expression, as in real estate, location is key. In this Select, we present two cases in which a specific histone modification causes changes to the local chromatin architecture, in turn impacting nearby gene regulation, and an example of how the spatial organization of loci creates an environment that leads to coregulation of ...
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Diffusion Based Looping of Chromatin [PDF]
Biophysical Journal, 2010 Chromatin folding inside the interphase nucleus of eukaryotic cells is done on multiple scales of length and time. Despite recent progress in understanding the folding motifs of chromatin, the higher-order folding still remains elusive. Flourescent in situ hybridization reveals a tight connection between genome folding and function as well as a folding
Heermann, Dieter W., Bohn, Manfred
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InferLoop: leveraging single-cell chromatin accessibility for the signal of chromatin loop
Briefings in Bioinformatics, 2023 Abstract Deciphering cell-type-specific 3D structures of chromatin is challenging. Here, we present InferLoop, a novel method for inferring the strength of chromatin interaction using single-cell chromatin accessibility data. The workflow of InferLoop is, first, to conduct signal enhancement by grouping nearby cells into bins, and then ...
Feng Zhang 0051 +9 more
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