Results 41 to 50 of about 303,776 (147)
Geometric partitioning of cohesin and condensin is a consequence of chromatin loops [PDF]
, 2018 SMC (structural maintenance of chromosomes) complexes condensin and cohesin are crucial for proper chromosome organization. Condensin has been reported to be a mechanochemical motor capable of forming chromatin loops, while cohesin passively diffuses ...
Friedman, B. +4 more
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Scientific Reports, 2022 The three-dimensional (3D) genome structure plays a fundamental role in gene regulation and cellular functions. Recent studies in 3D genomics inferred the very basic functional chromatin folding structures known as chromatin loops, the long-range ...
Zofia Parteka-Tojek +9 more
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Chromatin Switches and Loops [PDF]
Cell, 2013 In the realm of gene expression, as in real estate, location is key. In this Select, we present two cases in which a specific histone modification causes changes to the local chromatin architecture, in turn impacting nearby gene regulation, and an example of how the spatial organization of loci creates an environment that leads to coregulation of ...
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Genome Biology, 2021 Background The 3D organization of the chromatin fiber in cell nuclei plays a key role in the regulation of gene expression. Genome-wide techniques to score DNA-DNA contacts, such as Hi-C, reveal the partitioning of chromosomes into epigenetically defined
Xian Hao +6 more
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Diffusion Based Looping of Chromatin [PDF]
Biophysical Journal, 2010 Chromatin folding inside the interphase nucleus of eukaryotic cells is done on multiple scales of length and time. Despite recent progress in understanding the folding motifs of chromatin, the higher-order folding still remains elusive. Flourescent in situ hybridization reveals a tight connection between genome folding and function as well as a folding
Heermann, Dieter W., Bohn, Manfred
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CTCF mediates the cell-type specific spatial organization of the Kcnq5 locus and the local gene regulation. [PDF]
PLoS ONE, 2012 Chromatin loops play important roles in the dynamic spatial organization of genes in the nucleus. Growing evidence has revealed that the multivalent functional zinc finger protein CCCTC-binding factor (CTCF) is a master regulator of genome spatial ...
Licheng Ren +5 more
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PLoS Genetics, 2014 Friedreich ataxia (FRDA) and Fragile X syndrome (FXS) are among 40 diseases associated with expansion of repeated sequences (TREDs). Although their molecular pathology is not well understood, formation of repressive chromatin and unusual DNA structures ...
Matthias Groh +3 more
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, 2016 Many loops in chromatin demarcate contact domains. Usually the loops are anchored at a pair of convergent CTCF binding sites. It is hypothised that radiation is most effective by producing DSBs at the anchor locations by producing rings.
Jürgen Besserer (3228837) +2 more
core +1 more source
R-loop: an emerging regulator of chromatin dynamics [PDF]
Acta Biochimica et Biophysica Sinica, 2016 The dynamic structure of chromatin, which exists in two conformational states: heterochromatin and euchromatin, alters the accessibility of the DNA to regulatory factors during transcription, replication, recombination, and DNA damage repair. Chemical modifications of histones and DNA, as well as adenosine triphospahate-dependent nucleosome remodeling,
Qais, Al-Hadid, Yanzhong, Yang
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Proteomic interrogation of human chromatin. [PDF]
, 2011 Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. Here,
LeRoy, Gary +30 more
core +2 more sources