Results 31 to 40 of about 39,377 (243)
Chromatin Conformation in Development and Disease
Frontiers in Cell and Developmental Biology, 2021 Chromatin domains and loops are important elements of chromatin structure and dynamics, but much remains to be learned about their exact biological role and nature.
Ilias Boltsis +4 more
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Chromatin looping is needed for iPSC induction [PDF]
Cell Cycle, 2013 Terminally differentiated somatic cells can be reset to pluripotent capability either by ectopic expression of defined factors to form so-called “induced pluripotent stem cells” (iPSCs)1 or by empl...
Hu, Ji-Fan, Hoffman, Andrew R
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DNA loops after cell lysis resemble chromatin loops in an intact nucleus
The Ukrainian Biochemical Journal, 2018 The comet assay has proved itself to be not only a method of detection of DNA damages at the level of individual cells but also an approach for investigation of spatial organization of DNA loop domains in nucleoids.
K. S. Afanasieva +2 more
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The attachments of chromatin loops to the nucleoskeleton
Cell Biology International Reports, 1992 It is widely assumed by cell biologists that chromatin is looped by attachment to some nuclear skeleton. 'Structural' attachments might be mediated through specific sequences; these would be attached in most cells in an organism, underlying the basic structure of the mitotic chromosome and persisting throughout interphase.
Jackson, D +3 more
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SnapHiC2: A computationally efficient loop caller for single cell Hi-C data
Computational and Structural Biotechnology Journal, 2022 Single cell Hi-C (scHi-C) technologies enable the study of chromatin spatial organization directly from complex tissues at single cell resolution.
Xiaoqi Li +7 more
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Pharmacologic control of chromatin looping [PDF]
Blood, 2015 In this issue of Blood , [Krivega et al][1] establish a new method to reactivate fetal hemoglobin (HbF) production in adult human erythroid cells through pharmacologic manipulation of chromatin looping at the β-globin locus.[1][2] ![Figure][3] Different approaches to reactivate fetal γ-
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Chromatin loops, gene positioning, and gene expression [PDF]
Frontiers in Genetics, 2012 Technological developments and intense research over the last years have led to a better understanding of the 3D structure of the genome and its influence on genome function inside the cell nucleus. We will summarize topological studies performed on four model gene loci: the α- and β-globin gene loci, the antigen receptor loci, the imprinted H19-Igf2 ...
Holwerda, Sjoerd, Laat, Wouter de
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Scientific Reports, 2022 The three-dimensional (3D) genome structure plays a fundamental role in gene regulation and cellular functions. Recent studies in 3D genomics inferred the very basic functional chromatin folding structures known as chromatin loops, the long-range ...
Zofia Parteka-Tojek +9 more
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Genome Biology, 2021 Background The 3D organization of the chromatin fiber in cell nuclei plays a key role in the regulation of gene expression. Genome-wide techniques to score DNA-DNA contacts, such as Hi-C, reveal the partitioning of chromosomes into epigenetically defined
Xian Hao +6 more
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Chromatin Switches and Loops [PDF]
Cell, 2013 In the realm of gene expression, as in real estate, location is key. In this Select, we present two cases in which a specific histone modification causes changes to the local chromatin architecture, in turn impacting nearby gene regulation, and an example of how the spatial organization of loci creates an environment that leads to coregulation of ...
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