Results 31 to 40 of about 303,776 (147)
Chromatin Conformation in Development and Disease
Frontiers in Cell and Developmental Biology, 2021 Chromatin domains and loops are important elements of chromatin structure and dynamics, but much remains to be learned about their exact biological role and nature.
Ilias Boltsis +4 more
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The attachments of chromatin loops to the nucleoskeleton
Cell Biology International Reports, 1992 It is widely assumed by cell biologists that chromatin is looped by attachment to some nuclear skeleton. 'Structural' attachments might be mediated through specific sequences; these would be attached in most cells in an organism, underlying the basic structure of the mitotic chromosome and persisting throughout interphase.
Jackson, D +3 more
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Comparison of chromatin loops identified by DLoopCaller, HiCCUPS, Fit-HiC, and Peakachu in GM12878.
, 2022 (a) Venn diagram of identified chromatin loops determined by DLoopCaller CTCF ChIA-PET, HiCCUPS, Fit-HiC, and Peakachu in GM12878. (b) APA plots for DLoopCaller CTCF ChIA-PET loops, HiCCUPS, Fit-HiC, and Peakachu in GM12878.
Qinhu Zhang (12219347) +6 more
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Comparison of chromatin loops within individual cell types.
, 2022 (a) Distance distribution of DLoopCaller identified chromatin loops from Hi-C contact maps by using CTCF ChIA-PET, H3K27ac HiChIP, SMC1 HiChIP, RAD ChIA-PET, and promoter Capture Hi-C data after training on GM12878.
Qinhu Zhang (12219347) +6 more
core +1 more source
Non-specific interactions are sufficient to explain the position of heterochromatic chromocenters and nucleoli in interphase nuclei [PDF]
, 2009 The organization of the eukaryote nucleus into functional compartments arises by self-organization both through specific protein–protein and protein–DNA interactions and non-specific interactions that lead to entropic effects, such as e.g.
Nooijer, S., de +3 more
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Pharmacologic control of chromatin looping [PDF]
Blood, 2015 In this issue of Blood , [Krivega et al][1] establish a new method to reactivate fetal hemoglobin (HbF) production in adult human erythroid cells through pharmacologic manipulation of chromatin looping at the β-globin locus.[1][2] ![Figure][3] Different approaches to reactivate fetal γ-
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Chromatin loops, gene positioning, and gene expression [PDF]
Frontiers in Genetics, 2012 Technological developments and intense research over the last years have led to a better understanding of the 3D structure of the genome and its influence on genome function inside the cell nucleus. We will summarize topological studies performed on four model gene loci: the α- and β-globin gene loci, the antigen receptor loci, the imprinted H19-Igf2 ...
Holwerda, Sjoerd, Laat, Wouter de
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Histone methylation by PRC2 is inhibited by active chromatin marks [PDF]
, 2013 Chromatin modifiers serve as regulatory switches that control the cell cycle, maintain pluripotency and drive differentiation and development. Positive feedback mechanisms help to pass on transcriptional information from one generation of cells to the ...
Schmitges, Frank W.
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SnapHiC2: A computationally efficient loop caller for single cell Hi-C data
Computational and Structural Biotechnology Journal, 2022 Single cell Hi-C (scHi-C) technologies enable the study of chromatin spatial organization directly from complex tissues at single cell resolution.
Xiaoqi Li +7 more
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InferLoop: leveraging single-cell chromatin accessibility for the signal of chromatin loop
Briefings in Bioinformatics, 2023 Abstract Deciphering cell-type-specific 3D structures of chromatin is challenging. Here, we present InferLoop, a novel method for inferring the strength of chromatin interaction using single-cell chromatin accessibility data. The workflow of InferLoop is, first, to conduct signal enhancement by grouping nearby cells into bins, and then ...
Feng Zhang 0051 +9 more
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