Results 21 to 30 of about 303,776 (147)
ZNF143 in Chromatin Looping and Gene Regulation [PDF]
Frontiers in Genetics, 2020 ZNF143, a human homolog of the transcriptional activator Staf, is a C2H2-type protein consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence specifically binding to chromatin and activates the expression of protein-coding and non-coding genes on a genome scale.
Bingyu Ye +30 more
openaire +3 more sources
Anchoring Chromatin Loops to Cancer [PDF]
Developmental Cell, 2017 Although some genomic rearrangements are caused by replication or transcription, the etiology of others is unclear. Reporting in Cell, Canela et al. (2017) reveal that type II topoisomerase-mediated release of torsional strain at chromosomal loop anchors generates DNA double-strand breaks that drive multiple oncogenic translocations in a transcription ...
Faith, Fowler, Jessica K, Tyler
openaire +2 more sources
Chromatin loops of eight Gossypium species.
, 2021 Chromatin loops of eight Gossypium ...
Jianying Li (9426689)
core +1 more source
SnapFISH: a computational pipeline to identify chromatin loops from multiplexed DNA FISH data [PDF]
, 2022 Multiplexed DNA fluorescence in situ hybridization (FISH) imaging technologies have been developed to map the folding of chromatin fibers at tens of nanometer and tens of kilobase resolution in single cells.
Li, Yun +25 more
core +1 more source
Short‐range regulatory chromatin loops in plants [PDF]
New Phytologist, 2020 SummaryIn all eukaryotic organisms, gene expression correlates with the condensation state of the chromatin. Highly packed genome regions, known as heterochromatins, are associated with repressed loci, whereas euchromatic regions represent a relaxed state of the chromatin actively transcribed. However, even in these active regions, associations between
Delfina Gagliardi, Pablo A. Manavella
openaire +3 more sources
Closed chromatin loops at the ends of chromosomes [PDF]
The Journal of Cell Biology, 2004 The termini of eukaryotic chromosomes contain specialized protective structures, the telomeres, composed of TTAGGG repeats and associated proteins which, together with telomerase, control telomere length. Telomere shortening is associated with senescence and inappropriate telomerase activity may lead to cancer.
Nikitina, Tatiana +1 more
openaire +2 more sources
Loops and the activity of loop extrusion factors constrain chromatin dynamics [PDF]
Molecular Biology of the Cell, 2020 The relationship between chromatin structure and dynamics is incompletely understood. Here experimental and computational approaches are combined to reveal that looping interactions impose constraints on chromatin mobility while the ATP-dependent INO80 chromatin remodeler plays an important role in energy-dependent chromatin dynamics.
Mary Lou P. Bailey +8 more
openaire +2 more sources
Comparison of chromatin loops among cell types.
, 2022 (a) Distance distribution of DLoopCaller identified chromatin loops from Hi-C contact maps by using CTCF ChIA-PET data after training on GM12878, H1-ESC, and K562 (replicate1) separately.
Qinhu Zhang (12219347) +6 more
core +1 more source
Chromatin looping is needed for iPSC induction [PDF]
Cell Cycle, 2013 Terminally differentiated somatic cells can be reset to pluripotent capability either by ectopic expression of defined factors to form so-called “induced pluripotent stem cells” (iPSCs)1 or by empl...
Hu, Ji-Fan, Hoffman, Andrew R
openaire +2 more sources
ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL
eLife, 2020 Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL.
Gordana Wutz +19 more
doaj +1 more source