Results 21 to 30 of about 329,145 (275)
Landscape of cohesin-mediated chromatin loops in the human genome [PDF]
Nature, 2020 Marlene Rabinovitch +2 more
exaly +2 more sources
Chromatin Loop Extrusion and Chromatin Unknotting [PDF]
Polymers, 2018 It has been a puzzle how decondensed interphase chromosomes remain essentially unknotted. The natural expectation is that in the presence of type II DNA topoisomerases that permit passages of double-stranded DNA regions through each other, all chromosomes should reach the state of topological equilibrium.
Racko, Dusan +3 more
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Epigenetics & Chromatin, 2022 Background Regulatory elements such as promoters, enhancers, and insulators interact each other to mediate molecular processes. To capture chromatin interactions of regulatory elements, 3C-derived methods such as Hi-C and Micro-C are developed.
Beoung Hun Lee, Zexun Wu, Suhn K. Rhie
doaj +1 more source
R-loop landscape in mature human sperm: Regulatory and evolutionary implications
Frontiers in Genetics, 2023 R-loops are three-stranded nucleic acid structures consisting of an RNA:DNA hybrid and a displaced DNA strand. While R-loops pose a potential threat to genome integrity, they constitute 5% of the human genome.
Maurice Scheuren +2 more
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Spatial Organization of Chromatin: Transcriptional Control of Adaptive Immune Cell Development
Frontiers in Immunology, 2021 Higher-order spatial organization of the genome into chromatin compartments (permissive and repressive), self-associating domains (TADs), and regulatory loops provides structural integrity and offers diverse gene regulatory controls.
Jagan M. R. Pongubala, Cornelis Murre
doaj +1 more source
ZNF143 in Chromatin Looping and Gene Regulation [PDF]
Frontiers in Genetics, 2020 ZNF143, a human homolog of the transcriptional activator Staf, is a C2H2-type protein consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence specifically binding to chromatin and activates the expression of protein-coding and non-coding genes on a genome scale.
Bingyu Ye +30 more
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Anchoring Chromatin Loops to Cancer [PDF]
Developmental Cell, 2017 Although some genomic rearrangements are caused by replication or transcription, the etiology of others is unclear. Reporting in Cell, Canela et al. (2017) reveal that type II topoisomerase-mediated release of torsional strain at chromosomal loop anchors generates DNA double-strand breaks that drive multiple oncogenic translocations in a transcription ...
Faith, Fowler, Jessica K, Tyler
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Short‐range regulatory chromatin loops in plants [PDF]
New Phytologist, 2020 SummaryIn all eukaryotic organisms, gene expression correlates with the condensation state of the chromatin. Highly packed genome regions, known as heterochromatins, are associated with repressed loci, whereas euchromatic regions represent a relaxed state of the chromatin actively transcribed. However, even in these active regions, associations between
Delfina Gagliardi, Pablo A. Manavella
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Closed chromatin loops at the ends of chromosomes [PDF]
The Journal of Cell Biology, 2004 The termini of eukaryotic chromosomes contain specialized protective structures, the telomeres, composed of TTAGGG repeats and associated proteins which, together with telomerase, control telomere length. Telomere shortening is associated with senescence and inappropriate telomerase activity may lead to cancer.
Nikitina, Tatiana +1 more
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Loops and the activity of loop extrusion factors constrain chromatin dynamics [PDF]
Molecular Biology of the Cell, 2020 The relationship between chromatin structure and dynamics is incompletely understood. Here experimental and computational approaches are combined to reveal that looping interactions impose constraints on chromatin mobility while the ATP-dependent INO80 chromatin remodeler plays an important role in energy-dependent chromatin dynamics.
Mary Lou P. Bailey +8 more
openaire +2 more sources