Results 91 to 100 of about 578,337 (355)

Mutation in DDM1 inhibits the homology directed repair of double strand breaks.

PLoS ONE, 2019
In all organisms, DNA damage must be repaired quickly and properly, as it can be lethal for cells. Because eukaryotic DNA is packaged into nucleosomes, the structural units of chromatin, chromatin modification is necessary during DNA damage repair and is
Seung Hee Choi, Tae Ho Ryu, Jeong-Il Kim, Sungbeom Lee, Seung Sik Lee, Jin-Hong Kim   +5 more
doaj   +1 more source

Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease.

Cold Spring Harbor Symposia on Quantitative Biology, 2016
Mammalian SWI/SNF (BAF) chromatin remodeling complexes play critical roles in maintaining chromatin architecture and gene expression. Genomic sequencing efforts over the past several years have unveiled a major role for these complexes in the development
John L. Pulice, Cigall Kadoch
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

BCL7A and BCL7B potentiate SWI/SNF-complex-mediated chromatin accessibility to regulate gene expression and vegetative phase transition in plants

Nature Communications
Switch defective/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are multi-subunit machineries that establish and maintain chromatin accessibility and gene expression by regulating chromatin structure.
Yawen Lei, Yaoguang Yu, Wei Fu, Tao Zhu, Caihong Wu, Zhihao Zhang, Zewang Yu, Xin Song, Jianqu Xu, Zhenwei Liang, Peitao Lü, Chenlong Li   +11 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Human chromatin remodelers regulating HIV-1 transcription: a target for small molecule inhibitors

Epigenetics & Chromatin
HIV-1 can establish a lifelong infection by incorporating its proviral DNA into the host genome. Once integrated, the virus can either remain dormant or start active transcription, a process governed by the HIV Tat protein, host transcription factors and
Yuan Ma, Chuan Li, Susana Valente
doaj   +1 more source

Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling

eLife, 2016
Plants as sessile organisms can adapt to environmental stress to mitigate its adverse effects. As part of such adaptation they maintain an active memory of heat stress for several days that promotes a more efficient response to recurring stress.
Krzysztof Brzezinka, Simone Altmann, H. Czesnick, Philippe Nicolas, M. Górka, Eileen Benke, T. Kabelitz, Felix Jähne, Alexander Graf, C. Kappel, I. Bäurle   +10 more
semanticscholar   +1 more source

SnapShot: Chromatin Remodeling Complexes

Cell, 2007
Ino80 dIno80 hIno80 Swr1 SRCAP Domino P400Rvb1, Rvb2 Reptin, Pontin Tip49a, Tip49b Rvb1, Rvb2 Tip49a, Tip49b Reptin, Pontin Tip49a, Tip49bArp4,5,8, Act1 dArp5,8, dActin BAF53a, Arp5,8 Arp4,6, Act1 BAF53a, Arp6 BAP55, Act87E BAF53a, Actin Arp4, Act1Taf14 Yaf9 GAS41 dGAS41 GAS41 Yaf9Ies2 hIes2Ies6 hIes6Swc4/Eaf2 DMAP1 dDMAP1 DMAP1 Swc4/Eaf2Swc2/Vps72 YL ...
Bao, Yunhe, Shen, Xuetong
openaire   +2 more sources

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Activation of gene expression by histone deubiquitinase OTLD1

Epigenetics, 2017
One of the main mechanisms of epigenetic control is post translational modification of histones, and one of the relatively less characterized, yet functionally important histone modifications is monoubiquitylation, which is reversed by histone ...
Ido Keren, Vitaly Citovsky
doaj   +1 more source