Results 101 to 110 of about 201,890 (354)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression. [PDF]

, 2020
Retinoblastoma is an aggressive childhood cancer of the developing retina that initiates by biallelic RB1 gene inactivation. Tumor progression in retinoblastoma is driven by epigenetics, as retinoblastoma genomes are stable, but the mechanism(s) that ...
Benavente, Claudia A, Gu, Yijun, Mehta, Aditi, Spitale, Robert C, Suh, Susie, Wang, Jingtian, Wu, Jie, Wu, Stephanie C, Zocchi, Loredana   +8 more
core  

Pharmacological levels of withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells [PDF]

, 2014
Withaferin A (WA) isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-based
A Albini, A Cock-Rada, A Grigoriadis, An Wouters, AP Mazar, B Castellana, B Grin, B Jayaprakasam, D Hanahan, D Sarrio, Dariusz Ratman, DG Johnson, DR Hurst, ER Hahm, Erik Fransen, F Pereira, F Zambelli, Filip Lardon, G Chiappetta, G Natoli, GK Smyth, Guy Van Camp, H Yu, Ilse M. Beck, J Chia, J Lee, J Lee, JB Mitchem, JH Nijwening, JJ Steffan, JT Thaiparambil, K Belguise, K Miyazaki, Karen Heyninck, Karolien De Bosscher, Katarzyna Szarc vel Szic, KD Brown, Ken Declerck, Ken Op de Beeck, L Dumartin, L Ma, LC Mishra, LP Blair, M Endo, M Kaileh, M Tian, Marc Bracke, MD Edmonds, MJ Duffy, MJ Dunning, MN Ndlovu, N Brunner, N Pouliot, N Widodo, O De Wever, P Chi, PH O'Donnell, PJ Boimel, R Nanda, R Santana-Davila, Rajeev Samant, S Mirza, S Ramadoss, S Subbaram, SC Smith, SD Stan, SD Stan, SL Floor, TW Rockway, W Vanden Berghe, Wim Vanden Berghe, WL Berry, WW Bhat, Y He, YJ Surh   +74 more
core   +3 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Mutation in DDM1 inhibits the homology directed repair of double strand breaks.

PLoS ONE, 2019
In all organisms, DNA damage must be repaired quickly and properly, as it can be lethal for cells. Because eukaryotic DNA is packaged into nucleosomes, the structural units of chromatin, chromatin modification is necessary during DNA damage repair and is
Seung Hee Choi, Tae Ho Ryu, Jeong-Il Kim, Sungbeom Lee, Seung Sik Lee, Jin-Hong Kim   +5 more
doaj   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

BCL7A and BCL7B potentiate SWI/SNF-complex-mediated chromatin accessibility to regulate gene expression and vegetative phase transition in plants

Nature Communications
Switch defective/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are multi-subunit machineries that establish and maintain chromatin accessibility and gene expression by regulating chromatin structure.
Yawen Lei, Yaoguang Yu, Wei Fu, Tao Zhu, Caihong Wu, Zhihao Zhang, Zewang Yu, Xin Song, Jianqu Xu, Zhenwei Liang, Peitao Lü, Chenlong Li   +11 more
doaj   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Human chromatin remodelers regulating HIV-1 transcription: a target for small molecule inhibitors

Epigenetics & Chromatin
HIV-1 can establish a lifelong infection by incorporating its proviral DNA into the host genome. Once integrated, the virus can either remain dormant or start active transcription, a process governed by the HIV Tat protein, host transcription factors and
Yuan Ma, Chuan Li, Susana Valente
doaj   +1 more source

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source