Results 71 to 80 of about 578,337 (355)
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
ATP-dependent chromatin remodeling in the DNA-damage response
Epigenetics & Chromatin, 2012 The integrity of DNA is continuously challenged by metabolism-derived and environmental genotoxic agents that cause a variety of DNA lesions, including base alterations and breaks.
Lans Hannes +2 more
doaj +1 more source
Genome-wide chromatin remodeling identified at GC-rich long nucleosome-free regions. [PDF]
PLoS ONE, 2012 To gain deeper insights into principles of cell biology, it is essential to understand how cells reorganize their genomes by chromatin remodeling. We analyzed chromatin remodeling on next generation sequencing data from resting and activated T cells to ...
Karin Schwarzbauer +2 more
doaj +1 more source
Mechanical stretch promotes tenocyte migration via chromatin remodelling‐mediated nuclear morphology changes [PDF]
, 2023 Pu Xu +3 more
openalex +1 more source
Theory of active chromatin remodeling [PDF]
Physical Review Letters, 2019 Nucleosome positioning controls the accessible regions of chromatin and plays essential roles in DNA-templated processes. ATP driven remodeling enzymes are known to be crucial for its establishment in vivo, but their non-equilibrium nature has hindered the development of a unified theoretical framework for nucleosome positioning.
Jiang, Zhongling, Zhang, Bin
openaire +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Chromatin Modification and Remodeling in Heart Development
The Scientific World Journal, 2006 In organogenesis, cell types are specified from determined precursors as morphogenetic patterning takes place. These events are largely controlled by tissue-specific transcription factors.
Paul Delgado-Olguín +2 more
doaj +1 more source
The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA Damage
Frontiers in Cell and Developmental Biology, 2020 DNA packs into highly condensed chromatin to organize the genome in eukaryotes but occludes many regulatory DNA elements. Access to DNA within nucleosomes is therefore required for a variety of biological processes in cells including transcription ...
Ze-Bin Tong +3 more
doaj +1 more source
Adr1 and Cat8 mediate coactivator recruitment and chromatin remodeling at glucose-regulated genes. [PDF]
PLoS ONE, 2008 Adr1 and Cat8 co-regulate numerous glucose-repressed genes in S. cerevisiae, presenting a unique opportunity to explore their individual roles in coactivator recruitment, chromatin remodeling, and transcription.We determined the individual contributions ...
Rhiannon K Biddick +2 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source