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Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

open access: yesAdvanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan   +14 more
wiley   +1 more source

Nuclear expansion and chromatin structure remodeling in mouse aging neurons. [PDF]

open access: yesNAR Mol Med
Kriukov D   +8 more
europepmc   +1 more source

Improved simultaneous mapping of epigenetic features and 3D chromatin structure via ViCAR. [PDF]

open access: yesGenome Biol
Flynn SM   +10 more
europepmc   +1 more source

The senolytic cocktail, dasatinib and quercetin, impacts the chromatin structure of both young and senescent vascular smooth muscle cells. [PDF]

open access: yesGeroscience
Gadecka A   +6 more
europepmc   +1 more source
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Structure of Chromatin

Nature New Biology, 1971
Physico-chemical experiments show that histones are not evenly distributed in chromatin. About half of the DNA is “open” and not covered with proteins.
R J, Clark, G, Felsenfeld
openaire   +2 more sources

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