Results 251 to 260 of about 272,086 (309)

Tauroursodeoxycholic acid as a beneficial modulator for developmentally programed chromatin structure around specific genes. [PDF]

Front Endocrinol (Lausanne)
Itoh H, Aoyama T, Kohmura-Kobayashi Y, Tamura N, Nemoto T.   +4 more
europepmc   +1 more source

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

Advanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu, Rui Qiao, Ying Li, Junhong Li, Nuoya Yue, Jing Ge, Jiao Wang, Luonan Chen, Peiluan Li   +8 more
wiley   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Histone H1.0 couples cellular mechanical behaviors to chromatin structure. [PDF]

Nat Cardiovasc Res
Hu S, Chapski DJ, Gehred ND, Kimball TH, Gromova T, Flores A, Rowat AC, Chen J, Packard RRS, Olszewski E, Davis J, Rau CD, McKinsey TA, Rosa-Garrido M, Vondriska TM.   +14 more
europepmc   +1 more source

The jet-like chromatin structure defines active secondary metabolism in fungi. [PDF]

Nucleic Acids Res
Shao W, Wang J, Zhang Y, Zhang C, Chen J, Chen Y, Fei Z, Ma Z, Sun X, Jiao C.   +9 more
europepmc   +1 more source

A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer-promoter communication. [PDF]

Nat Struct Mol Biol
Denaud S, Bardou M, Papadopoulos GL, Grob S, Di Stefano M, Sabarís G, Nollmann M, Schuettengruber B, Cavalli G.   +8 more
europepmc   +1 more source

Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages. [PDF]

Epigenetics Chromatin
Qiu K, Vu DC, Wang L, Nguyen NN, Bookstaver AK, Sol-Church K, Li H, Dinh TN, Goldfarb AN, Tenen DG, Trinh BQ.   +10 more
europepmc   +1 more source

Chromosome engineering points to the cis-acting mechanism of chromosome arm-specific telomere length setting and robustness of plant phenotype, chromatin structure and gene expression. [PDF]

Plant J
Helia O, Matúšová B, Havlová K, Hýsková A, Lyčka M, Beying N, Puchta H, Fajkus J, Fojtová M.   +8 more
europepmc   +1 more source

The role of set1 methylation of histone H3 lysine 4 on chromatin structure in Saccharomyces cerevisiae

, 2005
Mars, Rochan
core