Results 281 to 290 of about 21,822,555 (337)

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk. [PDF]

Cell Genom
Kramer NE, Byun S, Coryell P, D'Costa S, Thulson E, Kim H, Parkus SM, Bond ML, Klein ER, Shine J, Chubinskaya S, Love MI, Mohlke KL, Diekman BO, Loeser RF, Phanstiel DH.   +15 more
europepmc   +1 more source

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Fluo-Cast-Bright: a deep learning pipeline for the non-invasive prediction of chromatin structure and developmental potential in live oocytes. [PDF]

Commun Biol
Zhang X, Baumann C, De La Fuente R.
europepmc   +1 more source

Tauroursodeoxycholic acid as a beneficial modulator for developmentally programed chromatin structure around specific genes. [PDF]

Front Endocrinol (Lausanne)
Itoh H, Aoyama T, Kohmura-Kobayashi Y, Tamura N, Nemoto T.   +4 more
europepmc   +1 more source

Histone H1.0 couples cellular mechanical behaviors to chromatin structure. [PDF]

Nat Cardiovasc Res
Hu S, Chapski DJ, Gehred ND, Kimball TH, Gromova T, Flores A, Rowat AC, Chen J, Packard RRS, Olszewski E, Davis J, Rau CD, McKinsey TA, Rosa-Garrido M, Vondriska TM.   +14 more
europepmc   +1 more source

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Histone exchange, chromatin structure and the regulation of transcription

Nature Reviews Molecular Cell Biology, 2015
Venkaṭesh S, Jerry Workman
exaly   +2 more sources

A bivalent chromatin structure marks key developmental genes in embryonic stem cells.

Cell, 2006
The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster within regions enriched for genes encoding developmentally important transcription factors (TFs).
B. Bernstein, T. Mikkelsen, Xiao-Hui Xie, Michael Kamal, Dana J. Huebert, James A. Cuff, B. Fry, A. Meissner, Marius Wernig, K. Plath, R. Jaenisch, Alexandre Wagschal, R. Feil, S. Schreiber, E. Lander   +14 more
semanticscholar   +1 more source

Structure of Chromatin

Nature New Biology, 1971
Physico-chemical experiments show that histones are not evenly distributed in chromatin. About half of the DNA is “open” and not covered with proteins.
R J, Clark, G, Felsenfeld
openaire   +2 more sources

THE STRUCTURE OF EUKARYOTE CHROMATIN

Acta Endocrinologica, 1972
ABSTRACT In this paper certain aspects of the structure of chromatin are considered, with emphasis on the relationships of histone and residual protein to DNA. Recent findings relative to the complexing of histone with DNA are reviewed and material from this laboratory concerning the ratio of total histone to DNA and related topics are ...
A L, Dounce, S K, Chanda, R, Ickowicz, D, Volkman, M, Palermiti, R, Turk   +5 more
openaire   +2 more sources