Results 51 to 60 of about 331 (102)

A Distinct Class of Chromoanagenesis Events Characterized by Focal Copy Number Gains

, 2016
Chromoanagenesis is the process by which a single catastrophic event creates complex rearrangements confined to a single or a few chromosomes. It is usually characterized by the presence of multiple deletions and/or duplications, as well as by copy ...
Van Esch, Hilde, Kleinfinger, Pascale, Afenjar, Alexandra, Schluth-Bolard, Caroline, Vermeesch, Joris, Plaisancié, Julie, Sanlaville, Damien, Masset, Heleen, Hestand, Matthew, Molignier, Romain   +9 more
core   +1 more source

EHA2024 Hybrid Congress

HemaSphere, Volume 8, Issue S1, June 2024.
wiley   +1 more source

Detection of complex genomic signatures associated with risk in plasma cell disorders

Plasma cell disorders (PCD) range from benign to highly malignant disease. The ability to detect risk-stratifying aberrations based on cytogenetic and molecular genetic assays plays an increasing role in therapeutic decision making.
Anoop Enjeti (21139238), Philip Rowlings (21275099), Rodney Scott (21131678), Nadine K. Berry (21283073), Amanda Dixon-McIver (46732)   +4 more
core  

Of Simple and Complex Genome Rearrangements, Chromothripsis, Chromoanasynthesis, and Chromosome Chaos [PDF]

Molecular Syndromology, 2017
openaire   +2 more sources

Investigation of the genetic and epigenetic bases of osteosarcomas [PDF]

INTRODUÇÃO: Cânceres pediátricos são a principal causa de mortalidade por doença nessa faixa etária, no Brasil e no mundo. Os tumores ósseos primários correspondem a cerca de 3% de todos os tumores da infância e adolescência, sendo osteossarcoma o mais ...
Pires, Sara Ferreira
core   +1 more source

Myeloid Neoplasms With KMT2A or MYC Amplification Exhibit Distinct Cytogenomic and Molecular Features and Clinical Outcomes

Context.— KMT2A (lysine methyltransferase 2A) and MYC (MYC proto-oncogene, bHLH transcription factor) amplifications are ...
Yi Huang, Min Yang, Madhu Ouseph, Madhulatha Pantrangi, Liming Bao   +4 more
core   +1 more source

CRISPRthripsis: The Risk of CRISPR/Cas9-induced Chromothripsis in Gene Therapy. [PDF]

Stem Cells Transl Med, 2022
Amendola M, Brusson M, Miccio A.
europepmc   +1 more source

Genomic instability, chromothripsis and cancer progression

, 2018
One of the biggest surprises to emerge from the cancer genome sequencing project has been the discovery of massively re-arranged genomes that have been detected within various types of human cancers caused by a novel mechanism called "chromothripsis ...
Gomes, Alexandra Galvão, Squire, Jeremy Andrew   +1 more
core  

Cancer Cytogenetics: Deep Roots, New Branches in the Age of Omics. [PDF]

Cancer Genomics Proteomics
Panagopoulos I.
europepmc   +1 more source

From Chromosomes to Precision Therapy: Clinical Cytogenetics and Cytogenomics in the Era of Genomic Medicine. [PDF]

Genes (Basel)
Liu J.
europepmc   +1 more source