Results 1 to 10 of about 4,624 (175)

Mouse chromocenters DNA content: sequencing and in silico analysis [PDF]

BMC Genomics, 2018
Background Chromocenters are defined as a punctate condensed blocks of chromatin in the interphase cell nuclei of certain cell types with unknown biological significance.
Dmitrii I. Ostromyshenskii, Ekaterina N. Chernyaeva, Inna S. Kuznetsova, Olga I. Podgornaya   +3 more
doaj   +4 more sources

Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes [PDF]

Communications Biology, 2023
The mechanisms leading to changes in mesoscale chromatin organization during cellular aging are unknown. Here, we used transcriptional activator-like effectors, RNA-seq and superresolution analysis to determine the effects of genotoxic stress on oocyte ...
Claudia Baumann, Xiangyu Zhang, Muthugapatti K. Kandasamy, Xiaohan Mei, Shiyou Chen, Kayvan F. Tehrani, Luke J. Mortensen, Wendy Watford, Ashley Lall, Rabindranath De La Fuente   +9 more
doaj   +2 more sources

The modular mechanism of chromocenter formation in Drosophila

eLife, 2019
A central principle underlying the ubiquity and abundance of pericentromeric satellite DNA repeats in eukaryotes has remained poorly understood. Previously we proposed that the interchromosomal clustering of satellite DNAs into nuclear structures known ...
Madhav Jagannathan, Ryan Cummings, Yukiko M Yamashita   +2 more
doaj   +2 more sources

Constitutive heterochromatin controls nuclear mechanics, morphology, and integrity through H3K9me3 mediated chromocenter compaction [PDF]

Nucleus
Aberrant nuclear morphology is a hallmark of human disease and causes nuclear dysfunction. Perturbed nuclear mechanics via reduced heterochromatin weakens the nucleus resulting in nuclear blebbing and rupture.
Gianna Manning, Andy Li, Nebiyat Eskndir, Marilena Currey, Andrew D. Stephens   +4 more
doaj   +2 more sources

L-2-hydroxyglutarate regulates centromere and heterochromatin conformation in the male germline. [PDF]

PLoS Genetics
Germ cell differentiation in the male testis involves extensive phenotypic, transcriptional, and epigenetic modifications, which are essential for producing functional spermatozoa.
Nina Mayorek, Miriam Schlossberg, Yousef Mansour, Nir Pillar, Ilan Stein, Fatima Mushasha, Guy Baziza Paz, Eleonora Medvedev, Zakhariya Manevitch, Julia Menzel, Elina Aizenshtein, Boris Sarvin, Nikita Sarvin, Erwin Goldberg, Bryan A Niedenberger, Christopher B Geyer, Tomer Shlomi, Michael Klutstein, Eli Pikarsky   +18 more
doaj   +2 more sources

SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state [PDF]

eLife
Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown.
Ruben Sebastian-Perez, Shoma Nakagawa, Xiaochuan Tu, Sergi Aranda, Martina Pesaresi, Pablo Aurelio Gomez-Garcia, Marc Alcoverro-Bertran, Jose Luis Gomez-Vazquez, Davide Carnevali, Eva Borràs, Eduard Sabidó, Laura Martin, Malka Nissim-Rafinia, Eran Meshorer, Maria Victoria Neguembor, Luciano Di Croce, Maria Pia Cosma   +16 more
doaj   +2 more sources

Multi-tissue characterization of the constitutive heterochromatin proteome in Drosophila identifies a link between satellite DNA organization and transposon repression. [PDF]

PLoS Biology
Noncoding satellite DNA repeats are abundant at the pericentromeric heterochromatin of eukaryotic chromosomes. During interphase, sequence-specific DNA-binding proteins cluster these repeats from multiple chromosomes into nuclear foci known as ...
Ankita Chavan, Lena Skrutl, Federico Uliana, Melanie Pfister, Franziska Brändle, Laszlo Tirian, Delora Baptista, Dominik Handler, David Burke, Anna Sintsova, Pedro Beltrao, Julius Brennecke, Madhav Jagannathan   +12 more
doaj   +2 more sources

Mechanisms governing the accessibility of DNA damage proteins to constitutive heterochromatin [PDF]

Frontiers in Genetics, 2022
Chromatin is thought to regulate the accessibility of the underlying DNA sequence to machinery that transcribes and repairs the DNA. Heterochromatin is chromatin that maintains a sufficiently high density of DNA packing to be visible by light microscopy ...
Anastasia Roemer, Lanah Mohammed, Hilmar Strickfaden, D. Alan Underhill, Michael J. Hendzel   +4 more
doaj   +2 more sources

NODeJ: an ImageJ plugin for 3D segmentation of nuclear objects [PDF]

BMC Bioinformatics, 2022
Background The three-dimensional nuclear arrangement of chromatin impacts many cellular processes operating at the DNA level in animal and plant systems.
Tristan Dubos, Axel Poulet, Geoffrey Thomson, Emilie Péry, Frédéric Chausse, Christophe Tatout, Sophie Desset, Josien C. van Wolfswinkel, Yannick Jacob   +8 more
doaj   +2 more sources

H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells [PDF]

Nat Commun
Arfè S, Karagyozova T, Forest A, Bingham D, Hmidan H, Mazaud D, Garnier M, Le Baccon P, Meshorer E, Quivy J, Almouzni G.   +10 more
europepmc   +3 more sources