Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions. [PDF]
PLoS Genetics, 2014 Long non-coding RNAs contribute to dosage compensation in both mammals and Drosophila by inducing changes in the chromatin structure of the X-chromosome.
Margarida L A Figueiredo +5 more
doaj +1 more source
Nanolesions induced by heavy ions in human tissues: experimental and theoretical studies [PDF]
, 2012 The biological effects of energetic heavy ions are attracting increasing interest for their applications in cancer therapy and protection against space radiation.
Cathrin Wälzlein +12 more
core +2 more sources
Structure and function of centromeric and pericentromeric heterochromatin in Arabidopsis thaliana
Frontiers in Plant Science, 2015 The centromere is a specific chromosomal region where the kinetochore assembles to ensure the faithful segregation of sister chromatids during mitosis and meiosis. Centromeres are defined by a local enrichment of the specific histone variant CenH3 mostly
Lauriane eSimon +3 more
doaj +1 more source
Genome restructuring in mouse embryos during reprogramming and early development [PDF]
, 1996 Although a growing number of studies investigates functional genome organization in somatic cell nuclei, it is largely unknown how mammalian genome organization is established during embryogenesis.
Martin, Catherine +5 more
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Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. [PDF]
, 2013 DNA methylation occurs in CG and non-CG sequence contexts. Non-CG methylation is abundant in plants and is mediated by CHROMOMETHYLASE (CMT) and DOMAINS REARRANGED METHYLTRANSFERASE (DRM) proteins; however, its roles remain poorly understood.
Do, Truman +7 more
core +2 more sources
Characterization of the Drosophila group ortholog to the amino-terminus of the alpha-thalassemia and mental retardation X-Linked (ATRX) vertebrate protein. [PDF]
PLoS ONE, 2014 The human ATRX gene encodes hATRX, a chromatin-remodeling protein harboring an helicase/ATPase and ADD domains. The ADD domain has two zinc fingers that bind to histone tails and mediate hATRX binding to chromatin.
Brenda López-Falcón +8 more
doaj +1 more source
Nejire/dCBP-mediated control of H3 acetylation and transcriptional regulation by testis-specific Plus3 domain proteins during Drosophila spermatogenesis [PDF]
, 2018 Spermatogenesis describes the development from germ line stem cells to highly specialized sperm. Drosophila melanogaster spermatogenesis is a good model system for chromatin remodelling processes as many of these processes are similar in mammals and in ...
Hundertmark, Tim
core +1 more source
Silencing markers are retained on pericentric heterochromatin during murine primordial germ cell development [PDF]
, 2017 Background: In the nuclei of most mammalian cells, pericentric heterochromatin is characterized by DNA methylation, histone modifications such as H3K9me3 and H4K20me3, and specific binding proteins ...
Baarends, W.M. (Willy) +8 more
core +1 more source
Chromosome and DNA methylation dynamics during meiosis in autotetraploid Arabidopsis arenosa [PDF]
, 2010 Variation in chromosome number due to polyploidy can seriously compromise meiotic stability. In autopolyploids, the presence of more than two homologous chromosomes may result in complex pairing patterns and subsequent anomalous chromosome ...
Ana Carvalho +35 more
core +1 more source
Role of dynamic nuclear deformation on genomic architecture reorganization.
PLoS Computational Biology, 2019 Higher-order genomic architecture varies according to cell type and changes dramatically during differentiation. One of the remarkable examples of spatial genomic reorganization is the rod photoreceptor cell differentiation in nocturnal mammals.
Sungrim Seirin-Lee +6 more
doaj +1 more source