Results 61 to 70 of about 5,729 (189)
Molecular Reproduction and Development, Volume 92, Issue 12, December 2025.ABSTRACT In ungulates, the development of the trophoblast lineage follows a peculiar process, as implantation is preceded by a relatively long period of trophoblast elongation, the molecular control of which is still not well known. Here, we have established novel bovine trophoblast stem cells (b2iTSCs) growing in a completely defined medium containing
Camille Baquerre +9 more
wiley +1 more source
SCaMC-1 like a member of the mitochondrial carrier (MC) family preferentially expressed in testis and localized in mitochondria and chromatoid body [PDF]
, 2012 Mitochondrial carriers (MC) form a highly conserved family involved in solute transport across the inner mitochondrial membrane in eukaryotes. In mammals, ATP-Mg/Pi carriers, SCaMCs, form the most complex subgroup with four paralogs, SCaMC-1, -2, -3 and -
Amigo, Ignacio +3 more
core +4 more sources
Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin. [PDF]
, 2020 Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Acevedo, David +7 more
core +3 more sources
Aggregation of the Constitutively Active K296E Rhodopsin Mutant Contributes to Retinal Degeneration
The FASEB Journal, Volume 39, Issue 14, 31 July 2025.The K296E rhodopsin mutation causes autosomal dominant retinitis pigmentosa. The pathogenic effect of the mutation has typically been attributed to effects related to the constitutive activity detected in the mutant in some studies. We demonstrate here that the K296E rhodopsin mutant aggregates.
Sreelakshmi Vasudevan +2 more
wiley +1 more source
Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy
MedComm – Oncology, Volume 4, Issue 2, June 2025.Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang +4 more
wiley +1 more source
Nuclear fusions contribute to polyploidization of the gigantic nuclei in the chalazal endosperm of Arabidopsis [PDF]
, 2018 Somatic polyploidization is recognized as a means to increase gene expression levels in highly active metabolic cells. The most common mechanisms are endoreplication, endomitosis and cell fusion.
Baroux, Célia +2 more
core
Chromatin Topological Domains Associate With the Rapid Formation of Tandem Duplicates in Plants
Advanced Science, Volume 12, Issue 7, February 17, 2025.A collection of Hi‐C matrices across the plant kingdom confirms the interrelation between large‐scale chromosome conformation and species genome size. At a finer level, tandem duplicate gene clusters preferentially fold into topologically associating domains (TADs) in an evolutionarily conserved manner.
Ni Ma +9 more
wiley +1 more source
Dynamic organization of chromatin domains revealed by super-resolution live-dell imaging [PDF]
, 2017 Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here by permission of Cell Press for personal use, not for redistribution.
Hibino, Kayo +10 more
core +1 more source
Characterization of radiations‐induced genomic structural variations in Arabidopsis thaliana
The Plant Journal, Volume 121, Issue 1, January 2025.Significance Statement Exposure to genotoxic stress activates DNA damage response (DDR) and challenges genome integrity. Using third generation sequencing technology, we characterized alterations of the linear genome structure of Arabidopsis plants treated with non‐ionizing (UV‐B, UV‐C) and ionizing radiations (protons). We identified, in wild type and
Salimata Ousmane Sall +9 more
wiley +1 more source
The Plant Journal, Volume 120, Issue 6, Page 2325-2336, December 2024.Significance Statement We ask here how diurnal changes impact chromatin modifications and gene expression. We have found that H3K27me1 is preferentially deposited during the night along the bodies of cell cycle and DNA damage response genes. Our study highlights the relevance of the diurnal control of the chromatin landscape of genes involved in genome
Jorge Fung‐Uceda +4 more
wiley +1 more source