Results 1 to 10 of about 86,167 (192)

Chromosomal instability, aneuploidy, and cancer [PDF]

Frontiers in Oncology, 2014
The link between aneuploidy and cancer has been recognized overa century ago (1). Abnormalities in chromosome copy numbersarise from persistent errors in chromosome segregation dur-ing cell division, a process known as chromosomal instability(CIN) (2).
Samuel F Bakhoum, Charles eSwanton
doaj   +3 more sources

Chromosomal Instability and Periodontal Disease in Idiopathic Infertility: Evidence of a Possible Association [PDF]

Biology
Background: Chromosomal instability (CIN) may underlie a subset of idiopathic infertility, and chronic periodontitis could contribute to genomic fragility.
Cristina-Crenguţa Albu, Ştefan-Dimitrie Albu, Claudia Florina Bogdan-Andreescu, Cristian-Viorel Poalelungi, Constantin Marian Damian, Alexandru Burcea, Andreea-Mariana Bănățeanu, Emin Cadar, Dan Alexandru Slăvescu, Anca Daniela Brăila   +9 more
doaj   +2 more sources

Chromosomal instability in human trophoblast stem cells and placentas. [PDF]

Nat Commun
Wang D, Cearlock A, Lane K, Xu C, Jan I, McCartney S, Glass I, McCoy R, Yang M.   +8 more
europepmc   +3 more sources

CINmetrics: an R package for analyzing copy number aberrations as a measure of chromosomal instability [PDF]

PeerJ, 2023
Genomic instability is an important hallmark of cancer and more recently has been identified in others like neurodegenrative diseases. Chromosomal instability, as a measure of genomic instability, has been used to characterize clinical and biological ...
Vishal H. Oza, Jennifer L. Fisher, Roshan Darji, Brittany N. Lasseigne   +3 more
doaj   +2 more sources

Chromosome instability syndromes [PDF]

Nature Reviews Disease Primers, 2019
Fanconi anaemia (FA), ataxia telangiectasia (A-T), Nijmegen breakage syndrome (NBS) and Bloom syndrome (BS) are clinically distinct, chromosome instability (or breakage) disorders. Each disorder has its own pattern of chromosomal damage, with cells from these patients being hypersensitive to particular genotoxic drugs, indicating that the underlying ...
Taylor, A. Malcolm R., Rothblum-Oviatt, Cynthia, Ellis, Nathan A., Hickson, Ian D., Meyer, Stefan, Crawford, Thomas O., Smogorzewska, Agata, Pietrucha, Barbara, Weemaes, Corry, Stewart, Grant S.   +9 more
openaire   +10 more sources

Profile of Chromosomal Alterations, Chromosomal Instability and Clonal Heterogeneity in Colombian Farmers Exposed to Pesticides

Frontiers in Genetics, 2022
Pesticides are a group of environmental pollutants widely used in agriculture to protect crops, and their indiscriminate use has led to a growing public awareness about the health hazards associated with exposure to these substances. In fact, exposure to
María Paula Meléndez-Flórez, Duvan Sebastián Valbuena, Sebastián Cepeda, Nelson Rangel, Maribel Forero-Castro, María Martínez-Agüero, Milena Rondón-Lagos   +6 more
doaj   +1 more source

Effect of chromosomal instability on the mutation-selection balance in unicellular populations. [PDF]

PLoS ONE, 2012
This paper develops a mathematical model describing the evolutionary dynamics of a unicellular, asexually replicating population exhibiting chromosomal instability.
Eran Itan, Emmanuel Tannenbaum
doaj   +1 more source

Genomic signatures of past and present chromosomal instability in Barrett’s esophagus and early esophageal adenocarcinoma

Nature Communications, 2023
The progression of precancerous lesions to malignancy is often accompanied by increasing complexity of chromosomal alterations but how these alterations arise is poorly understood.
Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston T. Agoston, Kunal Jajoo, Jon M. Davison, Katie S. Nason, Gad Getz, Kenneth K. Wang, Yu Imamura, Robert Odze, Adam J. Bass, Matthew D. Stachler, Cheng-Zhong Zhang   +17 more
doaj   +1 more source

Chromosome instability syndromes

Best Practice & Research Clinical Haematology, 2001
The chromosome instability syndromes, ataxia telangiectasia (A-T), Fanconi anaemia (FA) and Bloom syndrome (BS) have been known for many years. More recently Nijmegen breakage syndrome (NBS) and ataxia telangiectasia-like disorder (ATLD) have been identified.
Orlando J. Miller, Eeva Therman
  +6 more sources

Short-term molecular consequences of chromosome mis-segregation for genome stability

Nature Communications, 2023
Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.
Lorenza Garribba, Giuseppina De Feudis, Valentino Martis, Martina Galli, Marie Dumont, Yonatan Eliezer, René Wardenaar, Marica Rosaria Ippolito, Divya Ramalingam Iyer, Andréa E. Tijhuis, Diana C. J. Spierings, Michael Schubert, Silvia Taglietti, Chiara Soriani, Simon Gemble, Renata Basto, Nick Rhind, Floris Foijer, Uri Ben-David, Daniele Fachinetti, Ylli Doksani, Stefano Santaguida   +21 more
doaj   +1 more source